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. 1995 Jun;115(3):385–387. doi: 10.1111/j.1476-5381.1995.tb16344.x

Direct demonstration of sulphonylurea-sensitive KATP channels on nerve terminals of the rat motor cortex.

K Lee 1, A K Dixon 1, I C Rowe 1, M L Ashford 1, P J Richardson 1
PMCID: PMC1908424  PMID: 7582446

Abstract

We examined whether ATP-sensitive potassium (KATP) channels are present on presynaptic terminals of the rat motor cortex, an area of the CNS exhibiting a high density of sulphonylurea binding. A novel fused nerve terminal preparation was developed which produced structures amenable to patch clamp methods. In inside-out recordings a K+ channel was observed which possessed all the major features of the Type 1 KATP channel, including sensitivity to ATP and the antidiabetic sulphonylureas.

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Selected References

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