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. 1991 Oct;104(2):292–293. doi: 10.1111/j.1476-5381.1991.tb12423.x

Investigation into species variants in tachykinin NK1 receptors by use of the non-peptide antagonist, CP-96,345.

I J Beresford 1, P J Birch 1, R M Hagan 1, S J Ireland 1
PMCID: PMC1908580  PMID: 1665729

Abstract

The affinity of the non-peptide antagonist CP-96,345 for tachykinin NK1 receptors has been estimated in a range of species by use of both radioligand binding and functional assays. CP-96,345 was 30-120 fold less active at NK1 receptors in rat and mouse than in the other species examined, including man. These results demonstrate the existence of species variations in NK1 receptors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dam T. V., Quirion R. Pharmacological characterization and autoradiographic localization of substance P receptors in guinea pig brain. Peptides. 1986 Sep-Oct;7(5):855–864. doi: 10.1016/0196-9781(86)90106-3. [DOI] [PubMed] [Google Scholar]
  2. Gitter B. D., Waters D. C., Bruns R. F., Mason N. R., Nixon J. A., Howbert J. J. Species differences in affinities of non-peptide antagonists for substance P receptors. Eur J Pharmacol. 1991 May 17;197(2-3):237–238. doi: 10.1016/0014-2999(91)90532-u. [DOI] [PubMed] [Google Scholar]
  3. Ireland S. J., Bailey F., Cook A., Hagan R. M., Jordan C. C., Stephens-Smith M. L. Receptors mediating tachykinin-induced contractile responses in guinea-pig trachea. Br J Pharmacol. 1991 Jun;103(2):1463–1469. doi: 10.1111/j.1476-5381.1991.tb09812.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Nakanishi S. Mammalian tachykinin receptors. Annu Rev Neurosci. 1991;14:123–136. doi: 10.1146/annurev.ne.14.030191.001011. [DOI] [PubMed] [Google Scholar]
  5. Regoli D., D'Orléans-Juste P., Escher E., Mizrahi J. Receptors for substance P. I. The pharmacological preparations. Eur J Pharmacol. 1984 Jan 27;97(3-4):161–170. doi: 10.1016/0014-2999(84)90447-3. [DOI] [PubMed] [Google Scholar]
  6. Snider R. M., Constantine J. W., Lowe J. A., 3rd, Longo K. P., Lebel W. S., Woody H. A., Drozda S. E., Desai M. C., Vinick F. J., Spencer R. W. A potent nonpeptide antagonist of the substance P (NK1) receptor. Science. 1991 Jan 25;251(4992):435–437. doi: 10.1126/science.1703323. [DOI] [PubMed] [Google Scholar]

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