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. 1991 Dec;104(4):987–989. doi: 10.1111/j.1476-5381.1991.tb12537.x

Increased endothelin excretion in rats with renal failure induced by partial nephrectomy.

D P Brooks 1, L C Contino 1, B Storer 1, E H Ohlstein 1
PMCID: PMC1908829  PMID: 1810606

Abstract

1. Six weeks following partial nephrectomy in rats, significant increases in serum urea nitrogen and serum creatinine concentration and a significant decrease in creatinine clearance were observed. 2. Measurement of systolic blood pressure by tail plethysmography indicated that animals that had undergone partial nephrectomy were hypertensive. 3. Compared to sham-operated animals, there were 4 fold increases in both urinary protein excretion and urinary endothelin excretion. 4. There was a significant correlation between urinary protein and urinary endothelin excretion (r = 0.77). There was also a correlation (r = 0.65) between urinary endothelin excretion and systolic blood pressure. 5. Plasma endothelin concentrations were not different in sham-operated and partially nephrectomized rats. 6. The data indicate that there is an increased renal endothelin production in rats with chronic renal failure.

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Selected References

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