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. 1995 Sep;116(1):1704–1710. doi: 10.1111/j.1476-5381.1995.tb16395.x

Relationships between kallikrein secretion, kallikrein excretion and beta-adrenoceptors in kidney cortical slices from neurogenic hypertensive dogs.

C Damase-Michel 1, G Bompart 1, G Durrieu 1, J L Montastruc 1, P Montastruc 1, J P Girolami 1
PMCID: PMC1908911  PMID: 8564241

Abstract

1. Sinoaortic denervation (SAD) in dogs is characterized by an increase in blood pressure and heart rate as well as the development of renal morphological lesions similar to those observed in essential hypertension in human subjects. To assess the effect of SAD on the secretion of kallikrein kinin systems (KKS), we studied the in vitro secretion of kallikrein by renal cortical slices of normal and neurogenic hypertensive dogs (1 and 18 months after SAD). The method using renal cortical slices allowed the study of secretion of kallikrein independently of renal perfusion pressure. The number of renal beta-adrenoceptors was measured by [125I]-cyanopindolol binding. 2. SAD was associated with a marked increase in urinary kallikrein excretion at one month and a significant decrease at 18 months when compared with controls. Both changes were statistically significant (P < 0.05). Concurrently, a progressive increase in in vitro kallikrein secretion was observed (+80 +/- 10% and +179 +/- 48%, 1 and 18 months after SAD, respectively). Moreover, the cortical slices obtained from sinoaortic denervated dogs contained more kallikrein than the control cortical slices (+32 +/- 16% and +55 +/- 7%, 1 and 18 months after SAD, respectively). 3. Renal beta-adrenoceptor number significantly (P < 0.05) decreased 18 months after SAD from 18 +/- 2 to 8 +/- 3 fmol mg-1 protein without any change in affinity constant. 4. Although there was no test of association, because the number of renal beta-adrenoceptors decreased whereas kallikrein secretion increased, the present data could suggest a beta-adrenoceptor-mediated inhibition of kallikrein secretion.(ABSTRACT TRUNCATED AT 250 WORDS)

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Selected References

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  1. Albertini R., de Guevara R. L., Asenjo F., Boric M. Effect of renal nerve stimulation on urine and tissue kininogenase activity in cats. Hypertension. 1981 Nov-Dec;3(6 Pt 2):II–50-4. doi: 10.1161/01.hyp.3.6_pt_2.ii-50. [DOI] [PubMed] [Google Scholar]
  2. Churchill P. C., Churchill M. C., McDonald F. D. Evidence that beta 1-adrenoceptor activation mediates isoproterenol-stimulated renin secretion in the rat. Endocrinology. 1983 Aug;113(2):687–692. doi: 10.1210/endo-113-2-687. [DOI] [PubMed] [Google Scholar]
  3. Cowley A. W., Jr Long-term control of arterial blood pressure. Physiol Rev. 1992 Jan;72(1):231–300. doi: 10.1152/physrev.1992.72.1.231. [DOI] [PubMed] [Google Scholar]
  4. Damase-Michel C., Girolami J. P., Bascands J. L., Tran M. A., Moatti J. P., Pecher C., Berthet P., Tarrade T., Montastruc J. L. Effects of cicletanine on vasoactive systems in conscious sinoaortic-denervated dogs. Fundam Clin Pharmacol. 1991;5(8):719–732. doi: 10.1111/j.1472-8206.1991.tb00760.x. [DOI] [PubMed] [Google Scholar]
  5. Damase-Michel C., Montastruc J. L., Gharib C., Geelen G., De Saint-Blanquat G., Tran M. A. Effect of quinpirole, a specific dopamine DA2 receptor agonist on the sympathoadrenal system in dogs. J Pharmacol Exp Ther. 1990 Feb;252(2):770–777. [PubMed] [Google Scholar]
  6. Damase-Michel C., Valet P., Montastruc J. L. Nicardipine causes sympathetic activation that does not involve baroreceptor reflex tachycardia in conscious sinoaortic-denervated dogs. Eur J Pharmacol. 1987 Oct 6;142(1):145–149. doi: 10.1016/0014-2999(87)90665-0. [DOI] [PubMed] [Google Scholar]
  7. Dawson R., Jr, Oparil S. Renal catecholamines and alpha 2-adrenergic receptors in salt-related and genetic hypertension. Pharmacology. 1987;34(2-3):131–142. doi: 10.1159/000138262. [DOI] [PubMed] [Google Scholar]
  8. Deby C., Bourgain R. H., Andries R., Braquet P. Modulation of prostacyclin synthetase by cicletanine and drugs which affect ion transport. Pharmacol Res Commun. 1988 Sep;20 (Suppl 3):101–108. doi: 10.1016/s0031-6989(88)80109-7. [DOI] [PubMed] [Google Scholar]
  9. Deby C., Bourgain R. H., Deby-Dupont G., Pincemail J., Garay R. P., Braquet P. Modulation of in vivo generation of prostanoids by drugs affecting membrane ion transport. Drugs Exp Clin Res. 1988;14(2-3):123–134. [PubMed] [Google Scholar]
  10. Emond C., Bompart G., Rakotoarivony J., Bascands J. L., Pecher C., Adam A., Tarrade T., Berthet P., Girolami J. P. Protective effect of cicletanine on hypertension-induced decreases in the renal kallikrein-kinin and prostaglandin systems in stroke-prone spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1992 Oct;20(4):601–608. doi: 10.1097/00005344-199210000-00014. [DOI] [PubMed] [Google Scholar]
  11. Freissmuth M., Kraupp O., Hausleithner V., Tuisl E., Schütz W. Alterations of the glomerular beta-adrenoceptor-linked adenylate cyclase system in perinephritis hypertension. J Cardiovasc Pharmacol. 1986 Jan-Feb;8(1):60–66. doi: 10.1097/00005344-198601000-00010. [DOI] [PubMed] [Google Scholar]
  12. Galinier M., Sénard J. M., Valet P., Dréan G., Planat V., Arias A., Tran M. A., Montastruc J. L. Myocardial hypertrophy, cardiac beta-adrenoceptors and adenylate cyclase activity during sinoaortic denervation in dogs. Br J Pharmacol. 1992 Feb;105(2):341–346. doi: 10.1111/j.1476-5381.1992.tb14256.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Gardiner S. M., Kemp P. A., Bennett T., Bose C., Foulkes R., Hughes B. Involvement of beta 2-adrenoceptors in the regional haemodynamic responses to bradykinin in conscious rats. Br J Pharmacol. 1992 Apr;105(4):839–848. doi: 10.1111/j.1476-5381.1992.tb09066.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Girolami J. P., Bascands J. L., Pecher C., Suc J. M. Direct radioimmunoassay of rat urinary kallikrein: its application to the determination of active and inactive kallikrein concentration after HPLC analysis. J Immunoassay. 1987;8(1):115–130. doi: 10.1080/01971528708063057. [DOI] [PubMed] [Google Scholar]
  15. Girolami J. P., Bascands J. L., Praddaude F., Suc J. M. Change in cortical active kallikrein during the onset of Goldblatt hypertension in the rat. Adv Exp Med Biol. 1986;198(Pt B):279–283. doi: 10.1007/978-1-4757-0154-8_34. [DOI] [PubMed] [Google Scholar]
  16. Girolami J. P., Bascands J. L., Valet P., Pecher C., Cabos G. Beta-1 adrenergic inhibition of kallikrein release from rat kidney cortical slices. Am J Physiol. 1990 May;258(5 Pt 2):F1425–F1431. doi: 10.1152/ajprenal.1990.258.5.F1425. [DOI] [PubMed] [Google Scholar]
  17. Girolami J. P., Orfila C., Cabos-Boutot G., Pecher C., Bascands J. L., Colle A. Early acute effects of mercuric chloride on synthesis and release of kallikrein and on distal tubular morphology of rat renal cortical slices. Ren Physiol Biochem. 1990 Jul-Aug;13(4):223–232. doi: 10.1159/000173357. [DOI] [PubMed] [Google Scholar]
  18. Goldstein D. S. Plasma catecholamines and essential hypertension. An analytical review. Hypertension. 1983 Jan-Feb;5(1):86–99. doi: 10.1161/01.hyp.5.1.86. [DOI] [PubMed] [Google Scholar]
  19. Greenacre J. K., Conolly M. E. Desensitization of the beta-adrenoceptor of lymphocytes from normal subjects and patients with phaeochromocytoma: studies in vivo. Br J Clin Pharmacol. 1978 Mar;5(3):191–197. doi: 10.1111/j.1365-2125.1978.tb01623.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Hajjar D. P., Pomerantz K. B. Cicletanine stimulates cholesteryl ester hydrolase activities and prostacyclin production in arterial smooth muscle cells. Arch Mal Coeur Vaiss. 1989 Nov;82(SPEC):79–84. [PubMed] [Google Scholar]
  21. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  22. Margolius H. S., Geller R. G., De Jong W., Pisano J. J., Sjoerdsma A. Urinary kallikrein excretion in hypertension. Circ Res. 1972 Sep;31(9 Suppl):125–131. [PubMed] [Google Scholar]
  23. Margolius H. S. Tissue kallikreins and kinins: regulation and roles in hypertensive and diabetic diseases. Annu Rev Pharmacol Toxicol. 1989;29:343–364. doi: 10.1146/annurev.pa.29.040189.002015. [DOI] [PubMed] [Google Scholar]
  24. Marin-Grez M., Schaechtelin G., Bönner G., Speck G., Ganten D., Gross F. Renal kallikrein activity and urinary kallikrein excretion in rats with experimental renal hypertension. Clin Sci (Lond) 1982 Oct;63(4):349–354. doi: 10.1042/cs0630349. [DOI] [PubMed] [Google Scholar]
  25. McPherson G. A. Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. J Pharmacol Methods. 1985 Nov;14(3):213–228. doi: 10.1016/0160-5402(85)90034-8. [DOI] [PubMed] [Google Scholar]
  26. Michel M. C., Brodde O. E., Insel P. A. Peripheral adrenergic receptors in hypertension. Hypertension. 1990 Aug;16(2):107–120. doi: 10.1161/01.hyp.16.2.107. [DOI] [PubMed] [Google Scholar]
  27. Michel M. C., Kanczik R., Khamssi M., Knorr A., Siegl H., Beckeringh J. J., Brodde O. E. Alpha and beta-adrenoceptors in hypertension. I. Cardiac and renal alpha 1-, beta 1-, and beta 2-adrenoceptors in rat models of acquired hypertension. J Cardiovasc Pharmacol. 1989 Mar;13(3):421–431. doi: 10.1097/00005344-198903000-00010. [DOI] [PubMed] [Google Scholar]
  28. Michel M. C., Wang X. L., Schlicker E., Göthert M., Beckeringh J. J., Brodde O. E. Increased beta 2-adrenoreceptor density in heart, kidney and lung of spontaneously hypertensive rats. J Auton Pharmacol. 1987 Mar;7(1):41–51. doi: 10.1111/j.1474-8673.1987.tb00132.x. [DOI] [PubMed] [Google Scholar]
  29. Mills I. H., Obika L. F. A novel effect of intrarenal infusion of a non-vasoconstrictor dose of noradrenaline on renal function: relationship to renal kallikrein and prostaglandin [proceedings]. J Physiol. 1977 May;267(1):21P–22P. [PubMed] [Google Scholar]
  30. Misumi J., Alhenc-Gelas F., Marre M., Marchetti J., Corvol P., Menard J. Regulation of kallikrein and renin release by the isolated perfused rat kidney. Kidney Int. 1983 Jul;24(1):58–65. doi: 10.1038/ki.1983.126. [DOI] [PubMed] [Google Scholar]
  31. Nakamura K. T., Page W. V., Sato T., Klinkefus J. M., Robillard J. E. Ontogeny of isoproterenol-stimulated renin secretion from sheep renal cortical slices. Am J Physiol. 1989 Jun;256(6 Pt 2):R1258–R1263. doi: 10.1152/ajpregu.1989.256.6.R1258. [DOI] [PubMed] [Google Scholar]
  32. Nolly H., Lama M. C. Active and inactive kallikrein released by kidney slices from normotensive and hypertensive rats. Hypertension. 1981 Nov-Dec;3(6 Pt 2):II–35-8. doi: 10.1161/01.hyp.3.6_pt_2.ii-35. [DOI] [PubMed] [Google Scholar]
  33. Nustad K., Vaaje K., Pierce J. V. Synthesis of kallikreins by rat kidney slices. Br J Pharmacol. 1975 Feb;53(2):229–234. doi: 10.1111/j.1476-5381.1975.tb07353.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Orfila C., Damase-Michel C., Lepert J. C., Montastruc J. L., Suc J. M., Montastruc P., Girolami J. P. Renal morphological changes after sinoaortic denervation in dogs. Hypertension. 1993 Jun;21(6 Pt 1):758–766. doi: 10.1161/01.hyp.21.6.758. [DOI] [PubMed] [Google Scholar]
  35. Rascher W., Bönner G., Stocker M., Gross F. Increased kallikrein excretion in spontaneously hypertensive rats and its inhibition by 6-hydroxydopamine. Naunyn Schmiedebergs Arch Pharmacol. 1980 Aug;313(2):155–157. doi: 10.1007/BF00498573. [DOI] [PubMed] [Google Scholar]
  36. Siragy H. M., Jaffa A. A., Margolius H. S. Stimulation of renal interstitial bradykinin by sodium depletion. Am J Hypertens. 1993 Oct;6(10):863–866. doi: 10.1093/ajh/6.10.863. [DOI] [PubMed] [Google Scholar]
  37. Struyker-Boudier H. A., Vervoort-Peters L. H., Rousch M. J., Smits J. F., Thijssen H. H. Beta-adrenoceptors in kidney tubules of spontaneously hypertensive and normotensive rats. Life Sci. 1986 Jan 13;38(2):137–145. doi: 10.1016/0024-3205(86)90005-6. [DOI] [PubMed] [Google Scholar]
  38. Valet P., Damase-Michel C., Chamontin B., Durand D., Chollet F., Montastruc J. L. Platelet alpha 2- and leucocyte beta 2-adrenoceptors in phaeochromocytoma: effect of tumour removal. Eur J Clin Invest. 1988 Oct;18(5):481–485. doi: 10.1111/j.1365-2362.1988.tb01043.x. [DOI] [PubMed] [Google Scholar]
  39. Verbeuren T. J., Zonnekeyn L. L., Prost J. F., Rochat C., Thomas J. R., Herman A. G. The beta adrenoceptor blocker tertatolol causes vasodilatation in the isolated perfused vasoconstricted rat kidney. J Pharmacol Exp Ther. 1988 Aug;246(2):628–634. [PubMed] [Google Scholar]
  40. Vío C. P., Figueroa C. D. Subcellular localization of renal kallikrein by ultrastructural immunocytochemistry. Kidney Int. 1985 Jul;28(1):36–42. doi: 10.1038/ki.1985.115. [DOI] [PubMed] [Google Scholar]
  41. Woodcock E. A., Johnston C. I. Changes in tissue alpha- and beta-adrenergic receptors in renal hypertension in the rat. Hypertension. 1980 Mar-Apr;2(2):156–161. doi: 10.1161/01.hyp.2.2.156. [DOI] [PubMed] [Google Scholar]
  42. Yamada S., Ishima T., Tomita T., Hayashi M., Hayashi E. Increased renal beta-adrenoceptors in stroke-prone spontaneously hypertensive rats. Eur J Pharmacol. 1982 Sep 10;83(1-2):149–150. doi: 10.1016/0014-2999(82)90302-8. [DOI] [PubMed] [Google Scholar]
  43. Yamada S., Yamamura H. I., Roeske W. R. Alterations in central and peripheral adrenergic receptors in deoxycorticosterone/salt hypertensive rats. Life Sci. 1980 Dec 15;27(24):2405–2416. doi: 10.1016/0024-3205(80)90512-3. [DOI] [PubMed] [Google Scholar]
  44. de Bono E., Mills I. H. Proceedings: Simultaneous increases in kallikrein in renal lymph and urine during saline infusion. J Physiol. 1974 Sep;241(2):127P–128P. [PubMed] [Google Scholar]
  45. de Champlain J. Pre- and postsynaptic adrenergic dysfunctions in hypertension. J Hypertens Suppl. 1990 Dec;8(7):S77–S85. [PubMed] [Google Scholar]
  46. van Leeuwen B. H., Grinblat S. M., Johnston C. I. Release of active and inactive kallikrein from the isolated perfused rat kidney. Clin Sci (Lond) 1984 Feb;66(2):207–215. doi: 10.1042/cs0660207. [DOI] [PubMed] [Google Scholar]

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