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. 1996 Nov;70(11):8148–8150. doi: 10.1128/jvi.70.11.8148-8150.1996

Endogenous Mtv-encoded superantigens are not required for development of murine AIDS.

T C McCarty 1, S K Chattopadhyay 1, M T Scherer 1, T N Fredrickson 1, J W Hartley 1, H C Morse 3rd 1
PMCID: PMC190892  PMID: 8892943

Abstract

Immune activation in murine AIDS (MAIDS) has been suggested to involve a superantigen (SAG). The possibility that SAGs encoded by mammary tumor virus (MTV) might be the source of stimulation was studied by using Mtv mice. Mtv- mice developed typical MAIDS, excluding a requirement for Mtv-encoded SAGs in the pathogenesis of this disorder.

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Selected References

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  1. Acha-Orbea H., Shakhov A. N., Scarpellino L., Kolb E., Müller V., Vessaz-Shaw A., Fuchs R., Blöchlinger K., Rollini P., Billotte J. Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus. Nature. 1991 Mar 21;350(6315):207–211. doi: 10.1038/350207a0. [DOI] [PubMed] [Google Scholar]
  2. Aziz D. C., Hanna Z., Jolicoeur P. Severe immunodeficiency disease induced by a defective murine leukaemia virus. Nature. 1989 Apr 6;338(6215):505–508. doi: 10.1038/338505a0. [DOI] [PubMed] [Google Scholar]
  3. Chattopadhyay S. K., Morse H. C., 3rd, Makino M., Ruscetti S. K., Hartley J. W. Defective virus is associated with induction of murine retrovirus-induced immunodeficiency syndrome. Proc Natl Acad Sci U S A. 1989 May;86(10):3862–3866. doi: 10.1073/pnas.86.10.3862. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Chattopadhyay S. K., Sengupta D. N., Fredrickson T. N., Morse H. C., 3rd, Hartley J. W. Characteristics and contributions of defective, ecotropic, and mink cell focus-inducing viruses involved in a retrovirus-induced immunodeficiency syndrome of mice. J Virol. 1991 Aug;65(8):4232–4241. doi: 10.1128/jvi.65.8.4232-4241.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cloyd M. W., Hartley J. W., Rowe W. P. Genetic study of lymphoma induction by AKR mink cell focus-inducing virus in AKR x NFS crosses. J Exp Med. 1981 Aug 1;154(2):450–457. doi: 10.1084/jem.154.2.450. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cloyd M. W., Hartley J. W., Rowe W. P. Lymphomagenicity of recombinant mink cell focus-inducing murine leukemia viruses. J Exp Med. 1980 Mar 1;151(3):542–552. doi: 10.1084/jem.151.3.542. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Doyon L., Simard C., Sékaly R. P., Jolicoeur P. Evidence that the murine AIDS defective virus does not encode a superantigen. J Virol. 1996 Jan;70(1):1–9. doi: 10.1128/jvi.70.1.1-9.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Dyson P. J., Knight A. M., Fairchild S., Simpson E., Tomonari K. Genes encoding ligands for deletion of V beta 11 T cells cosegregate with mammary tumour virus genomes. Nature. 1991 Feb 7;349(6309):531–532. doi: 10.1038/349531a0. [DOI] [PubMed] [Google Scholar]
  9. Fitzpatrick E. A., Bryson J. S., Rhoads C., Kaplan A. M., Cohen D. A. T-deficient transmembrane signaling in CD4+ T cells of retroviral-induced immune-deficient mice. J Immunol. 1992 Jun 1;148(11):3377–3384. [PubMed] [Google Scholar]
  10. Frankel W. N., Rudy C., Coffin J. M., Huber B. T. Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice. Nature. 1991 Feb 7;349(6309):526–528. doi: 10.1038/349526a0. [DOI] [PubMed] [Google Scholar]
  11. Gazzinelli R. T., Eltoum I., Wynn T. A., Sher A. Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-alpha and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation. J Immunol. 1993 Oct 1;151(7):3672–3681. [PubMed] [Google Scholar]
  12. Giese N. A., Giese T., Morse H. C., 3rd Murine AIDS is an antigen-driven disease: requirements for major histocompatibility complex class II expression and CD4+ T cells. J Virol. 1994 Sep;68(9):5819–5824. doi: 10.1128/jvi.68.9.5819-5824.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hartley J. W., Fredrickson T. N., Yetter R. A., Makino M., Morse H. C., 3rd Retrovirus-induced murine acquired immunodeficiency syndrome: natural history of infection and differing susceptibility of inbred mouse strains. J Virol. 1989 Mar;63(3):1223–1231. doi: 10.1128/jvi.63.3.1223-1231.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Heise M., Chow K., Kanagawa O. Interaction between T cells and murine acquired immunodeficiency virus superantigen: effect of second signal on T cell reactivity to the MAIDS virus superantigen. Int Immunol. 1993 Jun;5(6):583–590. doi: 10.1093/intimm/5.6.583. [DOI] [PubMed] [Google Scholar]
  15. Hugo P., Kappler J. W., Marrack P. C. Positive selection of TcR alpha beta thymocytes: is cortical thymic epithelium an obligatory participant in the presentation of major histocompatibility complex protein? Immunol Rev. 1993 Oct;135:133–155. doi: 10.1111/j.1600-065x.1993.tb00647.x. [DOI] [PubMed] [Google Scholar]
  16. Hügin A. W., Vacchio M. S., Morse H. C., 3rd A virus-encoded "superantigen" in a retrovirus-induced immunodeficiency syndrome of mice. Science. 1991 Apr 19;252(5004):424–427. doi: 10.1126/science.1850169. [DOI] [PubMed] [Google Scholar]
  17. Janeway C. A., Jr Are there cellular superantigens? Immunol Rev. 1993 Feb;131:189–200. doi: 10.1111/j.1600-065x.1993.tb01536.x. [DOI] [PubMed] [Google Scholar]
  18. Kanagawa O., Nussrallah B. A., Wiebenga M. E., Murphy K. M., Morse H. C., 3rd, Carbone F. R. Murine AIDS superantigen reactivity of the T cells bearing V beta 5 T cell antigen receptor. J Immunol. 1992 Jul 1;149(1):9–16. [PubMed] [Google Scholar]
  19. Klinman D. M., Morse H. C., 3rd Characteristics of B cell proliferation and activation in murine AIDS. J Immunol. 1989 Feb 15;142(4):1144–1149. [PubMed] [Google Scholar]
  20. Makino M., Morse H. C., 3rd, Fredrickson T. N., Hartley J. W. H-2-associated and background genes influence the development of a murine retrovirus-induced immunodeficiency syndrome. J Immunol. 1990 Jun 1;144(11):4347–4355. [PubMed] [Google Scholar]
  21. Marrack P., Kushnir E., Kappler J. A maternally inherited superantigen encoded by a mammary tumour virus. Nature. 1991 Feb 7;349(6309):524–526. doi: 10.1038/349524a0. [DOI] [PubMed] [Google Scholar]
  22. Morawetz R. A., Doherty T. M., Giese N. A., Hartley J. W., Müller W., Kühn R., Rajewsky K., Coffman R., Morse H. C., 3rd Resistance to murine acquired immunodeficiency syndrome (MAIDS) Science. 1994 Jul 8;265(5169):264–267. doi: 10.1126/science.8023146. [DOI] [PubMed] [Google Scholar]
  23. Morse H. C., 3rd, Giese N., Morawetz R., Tang Y., Gazzinelli R., Kim W. K., Chattopadhyay S., Hartley J. W. Cells and cytokines in the pathogenesis of MAIDS, a retrovirus-induced immunodeficiency syndrome of mice. Springer Semin Immunopathol. 1995;17(2-3):231–245. doi: 10.1007/BF00196167. [DOI] [PubMed] [Google Scholar]
  24. Mosier D. E., Yetter R. A., Morse H. C., 3rd Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice. J Exp Med. 1985 Apr 1;161(4):766–784. doi: 10.1084/jem.161.4.766. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Muralidhar G., Koch S., Haas M., Swain S. L. CD4 T cells in murine acquired immunodeficiency syndrome: polyclonal progression to anergy. J Exp Med. 1992 Jun 1;175(6):1589–1599. doi: 10.1084/jem.175.6.1589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. O'Neill H. C., Jolly C. Retroviral superantigens. Immunol Today. 1992 Nov;13(11):462–463. doi: 10.1016/0167-5699(92)90078-L. [DOI] [PubMed] [Google Scholar]
  27. Scherer M. T., Ignatowicz L., Pullen A., Kappler J., Marrack P. The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire. J Exp Med. 1995 Nov 1;182(5):1493–1504. doi: 10.1084/jem.182.5.1493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Selvey L. A., Morse H. C., 3rd, Granger L. G., Hodes R. J. Preferential expansion and activation of V beta 5+ CD4+ T cells in murine acquired immunodeficiency syndrome. J Immunol. 1993 Aug 1;151(3):1712–1722. [PubMed] [Google Scholar]
  29. Wiseman R. W., Cochran C., Dietrich W., Lander E. S., Söderkvist P. Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3759–3763. doi: 10.1073/pnas.91.9.3759. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Yetter R. A., Buller R. M., Lee J. S., Elkins K. L., Mosier D. E., Fredrickson T. N., Morse H. C., 3rd CD4+ T cells are required for development of a murine retrovirus-induced immunodeficiency syndrome (MAIDS). J Exp Med. 1988 Aug 1;168(2):623–635. doi: 10.1084/jem.168.2.623. [DOI] [PMC free article] [PubMed] [Google Scholar]

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