Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1995 Oct;116(3):2120–2126. doi: 10.1111/j.1476-5381.1995.tb16420.x

Pharmacological characterization of behavioural responses to SK&F 83959 in relation to 'D1-like' dopamine receptors not linked to adenylyl cyclase.

A M Deveney 1, J L Waddington 1
PMCID: PMC1908936  PMID: 8640354

Abstract

1. Behavioural responses to the new benzazepine derivative, SK&F 83959, a compound that both fails to stimulate adenylyl cyclase and inhibits the stimulation of adenylyl cyclase induced by dopamine, were characterized in detail. 2. In rat striatal membrane preparations, radioligand binding studies with [3H]-SCH 23390 and [3H]-spiperone indicated SK&F 83959 had a high affinity and >250 fold selectivity for D1 over D2 receptors. 3. Using a rapid time-sampling behavioural check list technique, SK&F 83959 (0.01-1.25 mg kg(-1)) induced grooming in the manner of all known D1 receptor agonists, together with some vacuous chewing, which declined at higher doses with the emergence of directed chewing and rearing as an adjunct to prominent sniffing; no stereotyped behavioural was evident. 4. Grooming to SK&F 83959 (0.05 mg kg(-1)) was blocked by the selective D1 receptor antagonists, SCH 23390 (0.01-1.0 mg kg(-1)) and BW 737C (0.04-5.0 mg kg(-1)) and was attenuated by the selective D2 receptor antagonist, YM 09151-2 (0.005-0.5 mg kg(-1)); vacuous chewing to SK&F 83959 was not influenced by either SCH 23390 or BW 737C and was enhanced by YM 09151-2. 5. The paradoxical induction of typical D1 receptor agonist-induced grooming by SK&F 83959, an agent satisfying criteria for a D1 receptor antagonist as classically defined, together with its blockade by typical D1 antagonists, strongly suggests mediation via a 'D1-like' site that appears to respond similarly to agents independent of whether they exert agonist or antagonist actions at the classical adenylyl cyclase-coupled D1 receptor. This direct functional evidence for a 'D1-like' site that is not linked to adenylyl cyclase readily complements neurochemical data suggesting the existence of a cyclase-independent 'D1-like' receptor that may be coupled to phosphoinositide hydrolysis.

Full text

PDF
2120

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen P. H., Gingrich J. A., Bates M. D., Dearry A., Falardeau P., Senogles S. E., Caron M. G. Dopamine receptor subtypes: beyond the D1/D2 classification. Trends Pharmacol Sci. 1990 Jun;11(6):231–236. doi: 10.1016/0165-6147(90)90249-8. [DOI] [PubMed] [Google Scholar]
  2. Arnt J., Bøgesø K. P., Hyttel J., Meier E. Relative dopamine D1 and D2 receptor affinity and efficacy determine whether dopamine agonists induce hyperactivity or oral stereotypy in rats. Pharmacol Toxicol. 1988 Mar;62(3):121–130. doi: 10.1111/j.1600-0773.1988.tb01859.x. [DOI] [PubMed] [Google Scholar]
  3. Arnt J., Hyttel J., Sánchez C. Partial and full dopamine D1 receptor agonists in mice and rats: relation between behavioural effects and stimulation of adenylate cyclase activity in vitro. Eur J Pharmacol. 1992 Mar 24;213(2):259–267. doi: 10.1016/0014-2999(92)90690-6. [DOI] [PubMed] [Google Scholar]
  4. Briggs C. A., Pollock N. J., Frail D. E., Paxson C. L., Rakowski R. F., Kang C. H., Kebabian J. W. Activation of the 5-HT1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393. Br J Pharmacol. 1991 Dec;104(4):1038–1044. doi: 10.1111/j.1476-5381.1991.tb12546.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Civelli O., Bunzow J. R., Grandy D. K. Molecular diversity of the dopamine receptors. Annu Rev Pharmacol Toxicol. 1993;33:281–307. doi: 10.1146/annurev.pa.33.040193.001433. [DOI] [PubMed] [Google Scholar]
  6. Collins P., Broekkamp C. L., Jenner P., Marsden C. D. Drugs acting at D-1 and D-2 dopamine receptors induce identical purposeless chewing in rats which can be differentiated by cholinergic manipulation. Psychopharmacology (Berl) 1991;103(4):503–512. doi: 10.1007/BF02244250. [DOI] [PubMed] [Google Scholar]
  7. Daly S. A., Waddington J. L. Behavioural evidence for "D-1-like" dopamine receptor subtypes in rat brain using the new isochroman agonist A 68930 and isoquinoline antagonist BW 737C. Psychopharmacology (Berl) 1993;113(1):45–50. doi: 10.1007/BF02244332. [DOI] [PubMed] [Google Scholar]
  8. Daly S. A., Waddington J. L. The effects of clozapine on behavioural responses to the selective 'D1-like' dopamine receptor agonist, A 68930, and to the selective 'D2-like' agonist, RU 24213. Br J Pharmacol. 1994 Nov;113(3):839–844. doi: 10.1111/j.1476-5381.1994.tb17069.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. DeNinno M. P., Schoenleber R., MacKenzie R., Britton D. R., Asin K. E., Briggs C., Trugman J. M., Ackerman M., Artman L., Bednarz L. A68930: a potent agonist selective for the dopamine D1 receptor. Eur J Pharmacol. 1991 Jun 25;199(2):209–219. doi: 10.1016/0014-2999(91)90459-4. [DOI] [PubMed] [Google Scholar]
  10. Downes R. P., Waddington J. L. Grooming and vacuous chewing induced by SK&F 83959, an agonist of dopamine 'D1-like' receptors that inhibits dopamine-sensitive adenylyl cyclase. Eur J Pharmacol. 1993 Mar 30;234(1):135–136. doi: 10.1016/0014-2999(93)90718-w. [DOI] [PubMed] [Google Scholar]
  11. Giambalvo C. T., Wagner R. L. Activation of D1 and D2 dopamine receptors inhibits protein kinase C activity in striatal synaptoneurosomes. J Neurochem. 1994 Jul;63(1):169–176. doi: 10.1046/j.1471-4159.1994.63010169.x. [DOI] [PubMed] [Google Scholar]
  12. Gingrich J. A., Caron M. G. Recent advances in the molecular biology of dopamine receptors. Annu Rev Neurosci. 1993;16:299–321. doi: 10.1146/annurev.ne.16.030193.001503. [DOI] [PubMed] [Google Scholar]
  13. Gong L., Kostrzewa R. M., Fuller R. W., Perry K. W. Supersensitization of the oral response to SKF 38393 in neonatal 6-OHDA-lesioned rats is mediated through a serotonin system. J Pharmacol Exp Ther. 1992 Jun;261(3):1000–1007. [PubMed] [Google Scholar]
  14. Johansen P. A., Hu X. T., White F. J. Relationship between D1 dopamine receptors, adenylate cyclase, and the electrophysiological responses of rat nucleus accumbens neurons. J Neural Transm Gen Sect. 1991;86(2):97–113. doi: 10.1007/BF01250571. [DOI] [PubMed] [Google Scholar]
  15. Kebabian J. W., Calne D. B. Multiple receptors for dopamine. Nature. 1979 Jan 11;277(5692):93–96. doi: 10.1038/277093a0. [DOI] [PubMed] [Google Scholar]
  16. Laitinen J. T. Dopamine stimulates K+ efflux in the chick retina via D1 receptors independently of adenylyl cyclase activation. J Neurochem. 1993 Oct;61(4):1461–1469. doi: 10.1111/j.1471-4159.1993.tb13641.x. [DOI] [PubMed] [Google Scholar]
  17. Mahan L. C., Burch R. M., Monsma F. J., Jr, Sibley D. R. Expression of striatal D1 dopamine receptors coupled to inositol phosphate production and Ca2+ mobilization in Xenopus oocytes. Proc Natl Acad Sci U S A. 1990 Mar;87(6):2196–2200. doi: 10.1073/pnas.87.6.2196. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Mailman R. B., Schulz D. W., Kilts C. D., Lewis M. H., Rollema H., Wyrick S. Multiple forms of the D1 dopamine receptor: its linkage to adenylate cyclase and psychopharmacological effects. Psychopharmacol Bull. 1986;22(3):593–598. [PubMed] [Google Scholar]
  19. Molloy A. G., Waddington J. L. Assessment of grooming and other behavioural responses to the D-1 dopamine receptor agonist SK & F 38393 and its R- and S-enantiomers in the intact adult rat. Psychopharmacology (Berl) 1987;92(2):164–168. doi: 10.1007/BF00177909. [DOI] [PubMed] [Google Scholar]
  20. Molloy A. G., Waddington J. L. Dopaminergic behaviour stereospecific promoted by the D1 agonist R-SK & F 38393 and selectively blocked by the D1 antagonist SCH 23390. Psychopharmacology (Berl) 1984;82(4):409–410. doi: 10.1007/BF00427697. [DOI] [PubMed] [Google Scholar]
  21. Murray A. M., Waddington J. L. The induction of grooming and vacuous chewing by a series of selective D-1 dopamine receptor agonists: two directions of D-1:D-2 interaction. Eur J Pharmacol. 1989 Feb 7;160(3):377–384. doi: 10.1016/0014-2999(89)90093-9. [DOI] [PubMed] [Google Scholar]
  22. O'Boyle K. M., Gaitanopoulos D. E., Brenner M., Waddington J. L. Agonist and antagonist properties of benzazepine and thienopyridine derivatives at the D1 dopamine receptor. Neuropharmacology. 1989 Apr;28(4):401–405. doi: 10.1016/0028-3908(89)90036-1. [DOI] [PubMed] [Google Scholar]
  23. Riddall D. R. A comparison of the selectivities of SCH 23390 with BW737C89 for D1, D2 and 5-HT2 binding sites both in vitro and in vivo. Eur J Pharmacol. 1992 Jan 21;210(3):279–284. doi: 10.1016/0014-2999(92)90416-2. [DOI] [PubMed] [Google Scholar]
  24. Rosengarten H., Schweitzer J. W., Friedhoff A. J. Induction of oral dyskinesias in naive rats by D1 stimulation. Life Sci. 1983 Dec 19;33(25):2479–2482. doi: 10.1016/0024-3205(83)90155-8. [DOI] [PubMed] [Google Scholar]
  25. Rosengarten H., Schweitzer J. W., Friedhoff A. J. Selective dopamine D2 receptor reduction enhances a D1-mediated oral dyskinesia in rats. Life Sci. 1986 Jul 7;39(1):29–35. doi: 10.1016/0024-3205(86)90434-0. [DOI] [PubMed] [Google Scholar]
  26. Salamone J. D., Lalies M. D., Channell S. L., Iversen S. D. Behavioural and pharmacological characterization of the mouth movements induced by muscarinic agonists in the rat. Psychopharmacology (Berl) 1986;88(4):467–471. doi: 10.1007/BF00178508. [DOI] [PubMed] [Google Scholar]
  27. Schoors D. F., Vauquelin G. P., De Vos H., Smets G., Velkeniers B., Vanhaelst L., Dupont A. G. Identification of a D1 dopamine receptor, not linked to adenylate cyclase, on lactotroph cells. Br J Pharmacol. 1991 Aug;103(4):1928–1934. doi: 10.1111/j.1476-5381.1991.tb12354.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Sibley D. R., Monsma F. J., Jr, Shen Y. Molecular neurobiology of dopaminergic receptors. Int Rev Neurobiol. 1993;35:391–415. doi: 10.1016/s0074-7742(08)60573-5. [DOI] [PubMed] [Google Scholar]
  29. Stewart B. R., Jenner P., Marsden C. D. Induction of purposeless chewing behaviour in rats by 5-HT agonist drugs. Eur J Pharmacol. 1989 Mar 14;162(1):101–107. doi: 10.1016/0014-2999(89)90608-0. [DOI] [PubMed] [Google Scholar]
  30. Undie A. S., Friedman E. Stimulation of a dopamine D1 receptor enhances inositol phosphates formation in rat brain. J Pharmacol Exp Ther. 1990 Jun;253(3):987–992. [PubMed] [Google Scholar]
  31. Undie A. S., Weinstock J., Sarau H. M., Friedman E. Evidence for a distinct D1-like dopamine receptor that couples to activation of phosphoinositide metabolism in brain. J Neurochem. 1994 May;62(5):2045–2048. doi: 10.1046/j.1471-4159.1994.62052045.x. [DOI] [PubMed] [Google Scholar]
  32. Woodward R. M., Panicker M. M., Miledi R. Actions of dopamine and dopaminergic drugs on cloned serotonin receptors expressed in Xenopus oocytes. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4708–4712. doi: 10.1073/pnas.89.10.4708. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES