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. 1996 Nov;70(11):8234–8240. doi: 10.1128/jvi.70.11.8234-8240.1996

Murine leukemia virus-based Tat-inducible long terminal repeat replacement vectors: a new system for anti-human immunodeficiency virus gene therapy.

P M Cannon 1, N Kim 1, S M Kingsman 1, A J Kingsman 1
PMCID: PMC190909  PMID: 8892960

Abstract

We have constructed new murine leukemia virus (MLV)-based vectors (TIN vectors) which, following integration, contain human immunodeficiency virus (HIV) type 1 U3 and R sequences in place of the MLV U3 and R regions. This provides, for the first time, single transcriptional unit retroviral vectors under the control of Tat. TIN vectors have several advantages for anti-HIV gene therapy applications.

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Selected References

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