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. 1996 Jan;117(1):130–132. doi: 10.1111/j.1476-5381.1996.tb15164.x

The dose-related effects of paracetamol on hyperalgesia and nociception in the rat.

M Bianchi 1, A E Panerai 1
PMCID: PMC1909387  PMID: 8825353

Abstract

1. We have studied the effects of 3 low doses of paracetamol (25, 50 and 100 mg kg-1 p.o.) on inflammatory hyperalgesia, inflammatory oedema, and nociceptive thresholds in rats. 2. At the lower dose (25 mg kg-1), paracetamol reduces only central hyperalgesia. 3. At the doses of 50 and 100 mg kg-1, paracetamol reduces also peripheral hyperalgesia; moreover, it enhances nociceptive thresholds to a mechanical stimulus in the non-inflamed paws. 4. Neither paw inflammatory oedema nor tail nociceptive thresholds to a thermal stimulus were modified by paracetamol administration. 5. Our results suggest that paracetamol can reduce hyperalgesia without affecting physiological nociception and inflammation.

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Selected References

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  1. Bianchi M., Sacerdote P., Panerai A. E. Chlomipramine differently affects inflammatory edema and pain in the rat. Pharmacol Biochem Behav. 1994 Aug;48(4):1037–1040. doi: 10.1016/0091-3057(94)90217-8. [DOI] [PubMed] [Google Scholar]
  2. Bianchi M., Sacerdote P., Panerai A. E. Fluoxetine reduces inflammatory edema in the rat: involvement of the pituitary-adrenal axis. Eur J Pharmacol. 1994 Sep 22;263(1-2):81–84. doi: 10.1016/0014-2999(94)90526-6. [DOI] [PubMed] [Google Scholar]
  3. Björkman R., Hallman K. M., Hedner J., Hedner T., Henning M. Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P. Pain. 1994 Jun;57(3):259–264. doi: 10.1016/0304-3959(94)90001-9. [DOI] [PubMed] [Google Scholar]
  4. Carlsson K. H., Jurna I. Central analgesic effect of paracetamol manifested by depression of nociceptive activity in thalamic neurones of the rat. Neurosci Lett. 1987 Jun 26;77(3):339–343. doi: 10.1016/0304-3940(87)90524-6. [DOI] [PubMed] [Google Scholar]
  5. Clissold S. P. Paracetamol and phenacetin. Drugs. 1986;32 (Suppl 4):46–59. doi: 10.2165/00003495-198600324-00005. [DOI] [PubMed] [Google Scholar]
  6. Glenn E. M., Bowman B. J., Rohloff N. A. Anti-inflammatory and PG inhibitory effects of phenacetin and acetaminophen. Agents Actions. 1977 Dec;7(5-6):513–516. doi: 10.1007/BF02111123. [DOI] [PubMed] [Google Scholar]
  7. Hunskaar S., Fasmer O. B., Hole K. Acetylsalicylic acid, paracetamol and morphine inhibit behavioral responses to intrathecally administered substance P or capsaicin. Life Sci. 1985 Nov 11;37(19):1835–1841. doi: 10.1016/0024-3205(85)90227-9. [DOI] [PubMed] [Google Scholar]
  8. Lanz R., Polster P., Brune K. Antipyretic analgesics inhibit prostaglandin release from astrocytes and macrophages similarly. Eur J Pharmacol. 1986 Oct 14;130(1-2):105–109. doi: 10.1016/0014-2999(86)90188-3. [DOI] [PubMed] [Google Scholar]
  9. Malmberg A. B., Yaksh T. L. Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science. 1992 Aug 28;257(5074):1276–1279. doi: 10.1126/science.1381521. [DOI] [PubMed] [Google Scholar]
  10. McCormack K., Brune K. Dissociation between the antinociceptive and anti-inflammatory effects of the nonsteroidal anti-inflammatory drugs. A survey of their analgesic efficacy. Drugs. 1991 Apr;41(4):533–547. doi: 10.2165/00003495-199141040-00003. [DOI] [PubMed] [Google Scholar]
  11. McCormack K. The spinal actions of nonsteroidal anti-inflammatory drugs and the dissociation between their anti-inflammatory and analgesic effects. Drugs. 1994;47 (Suppl 5):28–47. doi: 10.2165/00003495-199400475-00006. [DOI] [PubMed] [Google Scholar]
  12. Meller S. T., Dykstra C., Gebhart G. F. Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-D-aspartate-produced facilitation of the nociceptive tail-flick reflex. Eur J Pharmacol. 1992 Apr 7;214(1):93–96. doi: 10.1016/0014-2999(92)90102-a. [DOI] [PubMed] [Google Scholar]
  13. Piletta P., Porchet H. C., Dayer P. Central analgesic effect of acetaminophen but not of aspirin. Clin Pharmacol Ther. 1991 Apr;49(4):350–354. doi: 10.1038/clpt.1991.40. [DOI] [PubMed] [Google Scholar]
  14. RANDALL L. O., SELITTO J. J., VALDES J. Anti-inflammatory effects of xylopropamine. Arch Int Pharmacodyn Ther. 1957 Dec 1;113(1-2):233–249. [PubMed] [Google Scholar]
  15. Ren K., Hylden J. L., Williams G. M., Ruda M. A., Dubner R. The effects of a non-competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation. Pain. 1992 Sep;50(3):331–344. doi: 10.1016/0304-3959(92)90039-E. [DOI] [PubMed] [Google Scholar]
  16. Taiwo Y. O., Levine J. D. Prostaglandins inhibit endogenous pain control mechanisms by blocking transmission at spinal noradrenergic synapses. J Neurosci. 1988 Apr;8(4):1346–1349. doi: 10.1523/JNEUROSCI.08-04-01346.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Tjølsen A., Lund A., Hole K. Antinociceptive effect of paracetamol in rats is partly dependent on spinal serotonergic systems. Eur J Pharmacol. 1991 Feb 7;193(2):193–201. doi: 10.1016/0014-2999(91)90036-p. [DOI] [PubMed] [Google Scholar]
  18. Woolf C. J. A new strategy for the treatment of inflammatory pain. Prevention or elimination of central sensitization. Drugs. 1994;47 (Suppl 5):1–47. doi: 10.2165/00003495-199400475-00003. [DOI] [PubMed] [Google Scholar]

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