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. 1996 Jun;118(4):957–960. doi: 10.1111/j.1476-5381.1996.tb15492.x

Dependence on temperature of the effect of dinitrophenol on the release of transmitter quanta at neuromuscular junctions in the mouse diaphragm.

M Nishimura 1, Y Taquahashi 1, K Fujita 1, E Satoh 1, Y Shimizu 1
PMCID: PMC1909503  PMID: 8799568

Abstract

1. The frequencies (F, s-1) of miniature endplate potentials and the quantal content (m) of endplate potentials were measured intracellularly and simultaneously at mouse diaphragm endplates in a bathing solution that contained 0.6 mM Ca2+ ions and 5 mM Mg2+ ions. 2. Twin pulses at 4 ms intervals gave the quantal contents of the first (m1) and second (m2) responses. The ratio of m2/m1 was taken as an indicator of the temporal facilitation of the release of transmitter. 3. Dinitrophenol (DNP, 10 microM) increased the values of F and m at 36 degrees C. This effect did not depend on extracellular Ca2+ ions. 4. The potentiating effect of DNP disappeared at 24 degrees C but the value of m2/m1 remained constant. 5. These results suggest that the effect of DNP is modifiable by temperature which can affect systems that control the intracellular metabolism of Ca2+ ions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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