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. 1996 Dec;70(12):8747–8751. doi: 10.1128/jvi.70.12.8747-8751.1996

Herpes simplex virus type 2 inhibition of Fas ligand expression.

S Sieg 1, Z Yildirim 1, D Smith 1, N Kayagaki 1, H Yagita 1, Y Huang 1, D Kaplan 1
PMCID: PMC190970  PMID: 8971002

Abstract

Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are common human pathogens. In this report we demonstrate the capacity of HSV-2, but not HSV-1, to inhibit the activity and cell surface expression of Fas ligand, an important molecule involved in T-cell apoptosis and cell-mediated cytotoxicity. Cells infected with HSV-2 retained Fas ligand intracellularly instead of expressing it on the cell surface. Addition of anti-Fas antibodies markedly inhibited HSV-2 viral production, suggesting that the capacity of the virus to regulate Fas ligand expression, and thereby programmed cell death, may represent a powerful mechanism for the virus to enhance viral replication.

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Selected References

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