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. 1996 Dec;70(12):8850–8857. doi: 10.1128/jvi.70.12.8850-8857.1996

Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S.

M Lu 1, T Shenk 1
PMCID: PMC190981  PMID: 8971013

Abstract

Human cytomegalovirus inhibits the growth of human foreskin fibroblast cells by 12 h after infection. Analysis of the cellular DNA content of infected cells by flow cytometry demonstrated that cytomegalovirus does not arrest cell cycle progression at a single point. At least two blockages occur, one of which is in the G1 phase of the cell cycle. The G1 arrest introduced by cytomegalovirus infection blocks S-phase entry after serum stimulation.

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Selected References

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