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. 1996 Aug;118(8):1875–1877. doi: 10.1111/j.1476-5381.1996.tb15618.x

Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat, in vivo.

L C Stanfa 1, V Chapman 1, N Kerr 1, A H Dickenson 1
PMCID: PMC1909884  PMID: 8864517

Abstract

Intrathecally administered nociceptin (5, 50, 225 micrograms) dose-relatedly inhibited the C-fibre evoked wind-up and post-discharge of dorsal horn neurones, but not the baseline C-fibre evoked responses. Spinal naloxone 50 micrograms, but not 10 micrograms, reversed the effects of nociceptin. Thus the antinociceptive role of nociceptin in the spinal cord differs from that of classical opioids.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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