Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1994 Feb;111(2):616–624. doi: 10.1111/j.1476-5381.1994.tb14781.x

Comparison of the effects of IVth ventricular administration of some tryptamine analogues with those of 8-OH-DPAT on autonomic outflow in the anaesthetized cat.

S L Shepheard 1, D Jordan 1, A G Ramage 1
PMCID: PMC1909979  PMID: 8004405

Abstract

1 The present study compares the effects on representative autonomic outflows of IVth ventricular application of tryptamine analogues which act at 5-HT1 receptors with 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). 2 Cumulative doses of 8-OH-DPAT, N,N-di-n-propyl-5-carboxamidotryptamine (DP-5-CT) and 5-carboxamidotryptamine (5-CT, 2.5-40 nmol kg-1), sumatriptan (10-160 nmol kg-1), indorenate (100-800 nmol kg-1), 5-hydroxytryptamine (5-HT, 20-640 nmol kg-1) both alone and in the presence of cinanserin (0.1 mg kg-1) were given into the IVth ventricle of cats which were anaesthetized with a mixture of alpha-chloralose and pentobarbitone sodium, neuromuscularly blocked and artificially ventilated. Recordings were made of arterial blood pressure, heart rate, renal, cardiac, splanchnic and phrenic nerve activities, femoral arterial flow, tracheal and intragastric pressures. 3 Central application of each of the agonists evoked significant falls in arterial blood pressure. In addition 8-OH-DPAT, DP-5-CT, 5-CT and 5-HT all evoked a differential inhibition of sympathetic nerve activities, with renal nerve activity being the most sensitive and cardiac nerve activity the least sensitive. In the dose-ranges used, administration of sumatriptan evoked reductions only in renal and splanchnic nerve activities whilst indorenate reduced activity in all three sympathetic nerves to a similar extent. 4 The effect of the agonists on heart rate was more inconsistent than the effects on sympathetic outflow.(ABSTRACT TRUNCATED AT 250 WORDS)

Full text

PDF
616

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bogle R. G., Pires J. G., Ramage A. G. Evidence that central 5-HT1A-receptors play a role in the von Bezold-Jarisch reflex in the rat. Br J Pharmacol. 1990 Aug;100(4):757–760. doi: 10.1111/j.1476-5381.1990.tb14088.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chitravanshi V. C., Calaresu F. R. Additive effects of dopamine and 8-OH-DPAT microinjected into the nucleus ambiguus in eliciting vagal bradycardia in rats. J Auton Nerv Syst. 1992 Nov;41(1-2):121–127. doi: 10.1016/0165-1838(92)90134-3. [DOI] [PubMed] [Google Scholar]
  3. Ciriello J., Caverson M. M., Polosa C. Function of the ventrolateral medulla in the control of the circulation. Brain Res. 1986 Dec;396(4):359–391. doi: 10.1016/0165-0173(86)90005-6. [DOI] [PubMed] [Google Scholar]
  4. Coote J. H., Dalton D. W., Fenuik W., Humphrey P. P. The central site of the sympatho-inhibitory action of 5-hydroxytryptamine in the cat. Neuropharmacology. 1987 Feb-Mar;26(2-3):147–154. doi: 10.1016/0028-3908(87)90202-4. [DOI] [PubMed] [Google Scholar]
  5. Doods H. N., Boddeke H. W., Kalkman H. O., Hoyer D., Mathy M. J., van Zwieten P. A. Central 5-HT1A receptors and the mechanism of the central hypotensive effect of (+)8-OH-DPAT, DP-5-CT, R28935, and urapidil. J Cardiovasc Pharmacol. 1988 Apr;11(4):432–437. doi: 10.1097/00005344-198804000-00008. [DOI] [PubMed] [Google Scholar]
  6. Gillis R. A., Hill K. J., Kirby J. S., Quest J. A., Hamosh P., Norman W. P., Kellar K. J. Effect of activation of central nervous system serotonin 1A receptors on cardiorespiratory function. J Pharmacol Exp Ther. 1989 Feb;248(2):851–857. [PubMed] [Google Scholar]
  7. Hamon M., Gozlan H., el Mestikawy S., Emerit M. B., Bolaños F., Schechter L. The central 5-HT1A receptors: pharmacological, biochemical, functional, and regulatory properties. Ann N Y Acad Sci. 1990;600:114–131. doi: 10.1111/j.1749-6632.1990.tb16877.x. [DOI] [PubMed] [Google Scholar]
  8. Hornby P. J., Rossiter C. D., White R. L., Norman W. P., Kuhn D. H., Gillis R. A. Medullary raphe: a new site for vagally mediated stimulation of gastric motility in cats. Am J Physiol. 1990 Apr;258(4 Pt 1):G637–G647. doi: 10.1152/ajpgi.1990.258.4.G637. [DOI] [PubMed] [Google Scholar]
  9. Humphrey P. P., Feniuk W., Perren M. J., Beresford I. J., Skingle M., Whalley E. T. Serotonin and migraine. Ann N Y Acad Sci. 1990;600:587–600. doi: 10.1111/j.1749-6632.1990.tb16912.x. [DOI] [PubMed] [Google Scholar]
  10. King K. A., Holtman J. R., Jr Characterization of the effects of activation of ventral medullary serotonin receptor subtypes on cardiovascular activity and respiratory motor outflow to the diaphragm and larynx. J Pharmacol Exp Ther. 1990 Feb;252(2):665–674. [PubMed] [Google Scholar]
  11. Laubie M., Drouillat M., Dabiré H., Cherqui C., Schmitt H. Ventrolateral medullary pressor area: site of hypotensive and sympatho-inhibitory effects of (+/-)8-OH-DPAT in anaesthetized dogs. Eur J Pharmacol. 1989 Feb 7;160(3):385–394. doi: 10.1016/0014-2999(89)90094-0. [DOI] [PubMed] [Google Scholar]
  12. Leff P., Martin G. R. The classification of 5-hydroxytryptamine receptors. Med Res Rev. 1988 Apr-Jun;8(2):187–202. doi: 10.1002/med.2610080203. [DOI] [PubMed] [Google Scholar]
  13. McAllen R. M., Dampney R. A. Vasomotor neurons in the rostral ventrolateral medulla are organized topographically with respect to type of vascular bed but not body region. Neurosci Lett. 1990 Mar 2;110(1-2):91–96. doi: 10.1016/0304-3940(90)90793-9. [DOI] [PubMed] [Google Scholar]
  14. McCall R. B., Patel B. N., Harris L. T. Effects of serotonin1 and serotonin2 receptor agonists and antagonists on blood pressure, heart rate and sympathetic nerve activity. J Pharmacol Exp Ther. 1987 Sep;242(3):1152–1159. [PubMed] [Google Scholar]
  15. Pazos A., Palacios J. M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res. 1985 Nov 4;346(2):205–230. doi: 10.1016/0006-8993(85)90856-x. [DOI] [PubMed] [Google Scholar]
  16. Peroutka S. J., McCarthy B. G. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. Eur J Pharmacol. 1989 Apr 12;163(1):133–136. doi: 10.1016/0014-2999(89)90406-8. [DOI] [PubMed] [Google Scholar]
  17. Ramage A. G. Examination of the effects of some 5-HT2 receptor antagonists on central sympathetic outflow and blood pressure in anaesthetised cats. Naunyn Schmiedebergs Arch Pharmacol. 1988 Dec;338(6):601–607. doi: 10.1007/BF00165623. [DOI] [PubMed] [Google Scholar]
  18. Ramage A. G., Fozard J. R. Evidence that the putative 5-HT1A receptor agonists, 8-OH-DPAT and ipsapirone, have a central hypotensive action that differs from that of clonidine in anaesthetised cats. Eur J Pharmacol. 1987 Jun 19;138(2):179–191. doi: 10.1016/0014-2999(87)90431-6. [DOI] [PubMed] [Google Scholar]
  19. Ramage A. G. Influence of 5-HT1A receptor agonists on sympathetic and parasympathetic nerve activity. J Cardiovasc Pharmacol. 1990;15 (Suppl 7):S75–S85. [PubMed] [Google Scholar]
  20. Ramage A. G., Wilkinson S. J. Evidence that different regional sympathetic outflows vary in their sensitivity to the sympathoinhibitory actions of putative 5-HT1A and alpha 2-adrenoceptor agonists in anaesthetized cats. Br J Pharmacol. 1989 Dec;98(4):1157–1164. doi: 10.1111/j.1476-5381.1989.tb12660.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Ramage A. G., Wouters W., Bevan P. Evidence that the novel antihypertensive agent, flesinoxan, causes differential sympathoinhibition and also increases vagal tone by a central action. Eur J Pharmacol. 1988 Jul 14;151(3):373–379. doi: 10.1016/0014-2999(88)90533-x. [DOI] [PubMed] [Google Scholar]
  22. Safdy M. E., Kurchacova E., Schut R. N., Vidrio H., Hong E. Tryptophan analogues. 1. Synthesis and antihypertensive activity of positional isomers. J Med Chem. 1982 Jun;25(6):723–730. doi: 10.1021/jm00348a022. [DOI] [PubMed] [Google Scholar]
  23. Shepheard S. L., Jordan D., Ramage A. G. Investigation of the effects of IVth ventricular administration of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), on autonomic outflow in the anaesthetized cat. Br J Pharmacol. 1991 Oct;104(2):367–372. doi: 10.1111/j.1476-5381.1991.tb12437.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Sporton S. C., Shepheard S. L., Jordan D., Ramage A. G. Microinjections of 5-HT1A agonists into the dorsal motor vagal nucleus produce a bradycardia in the atenolol-pretreated anaesthetized rat. Br J Pharmacol. 1991 Oct;104(2):466–470. doi: 10.1111/j.1476-5381.1991.tb12452.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES