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. 1994 Mar;111(3):829–836. doi: 10.1111/j.1476-5381.1994.tb14813.x

Differential action of (+)-amphetamine on electrically evoked dopamine overflow in rat brain slices containing corpus striatum and nucleus accumbens.

W J Wieczorek 1, Z L Kruk 1
PMCID: PMC1910092  PMID: 8019759

Abstract

1. The effects of (+)-amphetamine on electrically evoked dopamine overflow were examined in the rat brain slice containing either anterior caudate putamen (aCPu) or nucleus accumbens (NAc), by fast cyclic voltammetry. 2. (+)-Amphetamine (1 microM) caused a time-dependent increase in the extracellular concentration of dopamine ([dopamine]ex) due to displacement of dopamine from terminal sites. After a 40 min superfusion, [dopamine]ex in the aCPu was 0.617 +/- 0.117 microM and in the NAc was 0.270 +/- 0.04 microM. Pretreatment with (-)-sulpiride (1 microM) did not affect this action of (+)-amphetamine. 3. (+)-Amphetamine (1 microM) exhibited a complex and time-dependent effect on electrically stimulated dopamine overflow, evoked by 1p, 4p/10 Hz and 20p/20 Hz. 4. In the aCPu, (+)-amphetamine (1 microM) resulted in attenuation of dopamine overflow due to 1p and 4p/10 Hz but potentiation of dopamine overflow to 20p/20 Hz. (-)-Sulpiride (1 microM) prior to (+)-amphetamine (1 microM) reversed the attenuation of dopamine overflow evoked by 1p and 4p/10 Hz but had no significant effect on dopamine overflow evoked by 20p/20 Hz. 5. (+)-Amphetamine (1 microM) potentiated dopamine overflow in the NAc to all three stimuli. (-)-Sulpiride (1 microM) prior to (+)-amphetamine (1 microM), resulted initially, in a further potentiation of overflow, followed by a time-dependent attenuation of dopamine overflow to all three stimuli. 6. t1/2, the rate of removal of [dopamine]ex following electrical stimulation was not significantly different in the aCPu and NAc for any of the stimulation conditions.(ABSTRACT TRUNCATED AT 250 WORDS)

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