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. 1996 Dec;70(12):9060–9063. doi: 10.1128/jvi.70.12.9060-9063.1996

Quasispecies in wild-type tula hantavirus populations.

A Plyusnin 1, Y Cheng 1, H Lehväslaiho 1, A Vaheri 1
PMCID: PMC191012  PMID: 8971044

Abstract

Tula virus (TUL) is a recently detected hantavirus carried by European common voles. Reverse transcriptase PCR cloning was used to study TUL S segment/N protein quasispecies. Both the distribution and character of mutations observed in three mutant spectra indicated limited selection at the protein level. At least 8% of the mutations were neutral or well tolerated; fixation of such mutations may play a role in TUL evolution in its natural host.

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Selected References

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