Abstract
D-Serine, a selective agonist for the strychnine-insensitive glycine allosteric site associated with the NMDA receptor-ion channel complex, was found to modulate differentially the antinociception produced by kappa and mu-opioid receptor agonists in the rat formalin test. D-Serine (100 micrograms, i.c.v.) attenuated the antinociception produced by the selective kappa-opioid agonist, enadoline (0.003-0.1 mg kg-1, s.c.) against the tonic, but not acute, phase of the formalin response. Conversely, D-serine potentiated the antinociception produced by morphine (0.3-10 mg kg-1, s.c.) against both the acute and tonic phases. These results demonstrate an important interaction between the opioid and NMDA/glycine systems in the control of nociceptive information possibly at different levels of the neuraxis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Haley J. E., Sullivan A. F., Dickenson A. H. Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat. Brain Res. 1990 Jun 4;518(1-2):218–226. doi: 10.1016/0006-8993(90)90975-h. [DOI] [PubMed] [Google Scholar]
- Hunter J. C., Leighton G. E., Meecham K. G., Boyle S. J., Horwell D. C., Rees D. C., Hughes J. CI-977, a novel and selective agonist for the kappa-opioid receptor. Br J Pharmacol. 1990 Sep;101(1):183–189. doi: 10.1111/j.1476-5381.1990.tb12110.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jacquet Y. F. The NMDA receptor: central role in pain inhibition in rat periaqueductal gray. Eur J Pharmacol. 1988 Sep 23;154(3):271–276. doi: 10.1016/0014-2999(88)90201-4. [DOI] [PubMed] [Google Scholar]
- Pinnock R. D. A highly selective kappa-opioid receptor agonist, CI-977, reduces excitatory synaptic potentials in the rat locus coeruleus in vitro. Neuroscience. 1992;47(1):87–94. doi: 10.1016/0306-4522(92)90123-j. [DOI] [PubMed] [Google Scholar]
- Singh L., Vass C. A., Hunter J. C., Woodruff G. N., Hughes J. The anticonvulsant action of CI-977, a selective kappa-opioid receptor agonist: a possible involvement of the glycine/NMDA receptor complex. Eur J Pharmacol. 1990 Dec 4;191(3):477–480. doi: 10.1016/0014-2999(90)94183-x. [DOI] [PubMed] [Google Scholar]
- Stevens C. W., Lacey C. B., Miller K. E., Elde R. P., Seybold V. S. Biochemical characterization and regional quantification of mu, delta and kappa opioid binding sites in rat spinal cord. Brain Res. 1991 May 31;550(1):77–85. doi: 10.1016/0006-8993(91)90407-m. [DOI] [PubMed] [Google Scholar]
- Wheeler-Aceto H., Cowan A. Standardization of the rat paw formalin test for the evaluation of analgesics. Psychopharmacology (Berl) 1991;104(1):35–44. doi: 10.1007/BF02244551. [DOI] [PubMed] [Google Scholar]
- van Praag H., Frenk H. The role of glutamate in opiate descending inhibition of nociceptive spinal reflexes. Brain Res. 1990 Jul 30;524(1):101–105. doi: 10.1016/0006-8993(90)90497-y. [DOI] [PubMed] [Google Scholar]