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. 1974 Oct;77(1):85–102.

Are Viruses Important in Carcinogenesis?

Fred Rapp, Ellen R Buss
PMCID: PMC1910716  PMID: 4374889

Abstract

The role of viruses in the etiology of animal cancers is fairly certain. Information derived under both natural and experimental conditions supports the concept that either DNA- or RNA-containing viruses can fulfill this function. The DNA-containing herpesviruses, especially the Epstein-Barr virus, are currently the primary objects of intense investigation concerning their role in human cancer. This article will focus on the properties of counterpart herpesviruses in lower animals as well as the human virus candidates with an assessment of the observations concerning their oncogenic potential.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adam E., Kaufman R. H., Melnick J. L., Levy A. H., Rawls W. E. Seroepidemiologic studies of herpesvirus type 2 and carcinoma of the cervix. 3. Houston, Texas. Am J Epidemiol. 1972 Dec;96(6):427–442. doi: 10.1093/oxfordjournals.aje.a121475. [DOI] [PubMed] [Google Scholar]
  2. Adams A., Lindahl T., Klein G. Linear association between cellular DNA and Epstein-Barr virus DNA in a human lymphoblastoid cell line. Proc Natl Acad Sci U S A. 1973 Oct;70(10):2888–2892. doi: 10.1073/pnas.70.10.2888. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Albrecht T., Rapp F. Malignant transformation of hamster embryo fibroblasts following exposure to ultraviolet-irradiated human cytomegalovirus. Virology. 1973 Sep;55(1):53–61. doi: 10.1016/s0042-6822(73)81007-4. [DOI] [PubMed] [Google Scholar]
  4. Aurelian L., Schumann B., Marcus R. L., Davis H. J. Antibody to HSV-2 induced tumor specific antigens in serums from patients with cervical carcinoma. Science. 1973 Jul 13;181(4095):161–164. doi: 10.1126/science.181.4095.161. [DOI] [PubMed] [Google Scholar]
  5. Aurelian L., Strandberg J. D., Davis H. J. HSV-2 antigens absent from biopsied cervical tumor cells: a model consistent with latency. Proc Soc Exp Biol Med. 1972 Jun;140(2):404–408. doi: 10.3181/00379727-140-36468. [DOI] [PubMed] [Google Scholar]
  6. Aurelian L., Strandberg J. D., Melendez L. V., Johnson L. A. Herpesvirus type 2 isolated from cervical tumor cells grown in tissue culture. Science. 1971 Nov 12;174(4010):704–707. doi: 10.1126/science.174.4010.704. [DOI] [PubMed] [Google Scholar]
  7. Biggs P. M., Thorpe R. J., Payne L. N. Studies on genetic resistance to Marek's disease in the domestic chicken. Br Poult Sci. 1968 Jan;9(1):37–52. doi: 10.1080/00071666808415692. [DOI] [PubMed] [Google Scholar]
  8. Breidenbach G. P., Skinner M. S., Wallace J. H., Mizell M. In vitro induction of a herpes-type virus in "summer-phase" Lucké tumor explants. J Virol. 1971 May;7(5):679–682. doi: 10.1128/jvi.7.5.679-682.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Burkitt D. P. Etiology of Burkitt's lymphoma--an alternative hypothesis to a vectored virus. J Natl Cancer Inst. 1969 Jan;42(1):19–28. [PubMed] [Google Scholar]
  10. Calnek B. W., Adldinger H. K., Kahn D. E. Feather follicle epithelium: a source of enveloped and infectious cell-free herpesvirus from Marek's disease. Avian Dis. 1970 May;14(2):219–233. [PubMed] [Google Scholar]
  11. Calnek B. W., Hitchner S. B. Localization of viral antigen in chickens infected with Marek's disease herpesvirus. J Natl Cancer Inst. 1969 Oct;43(4):935–949. [PubMed] [Google Scholar]
  12. Centifanto Y. M., Kaufman H. E., Zam Z. S., Drylie D. M., Deardourff S. L. Herpesvirus particles in prostatic carcinoma cells. J Virol. 1973 Dec;12(6):1608–1611. doi: 10.1128/jvi.12.6.1608-1611.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Chang R. S., Golden H. D. Transformation of human leucocytes by throat washing from infectious mononucleosis patients. Nature. 1971 Dec 10;234(5328):359–360. doi: 10.1038/234359a0. [DOI] [PubMed] [Google Scholar]
  14. Churchill A. E., Biggs P. M. Agent of Marek's disease in tissue culture. Nature. 1967 Jul 29;215(5100):528–530. doi: 10.1038/215528a0. [DOI] [PubMed] [Google Scholar]
  15. Churchill A. E., Payne L. N., Chubb R. C. Immunization against Marek's disease using a live attenuated virus. Nature. 1969 Feb 22;221(5182):744–747. doi: 10.1038/221744a0. [DOI] [PubMed] [Google Scholar]
  16. Collard W., Thornton H., Green M. Cells transformed by human Herpesvirus type 2 transcribe virus-specific RNA sequences shared by Herpesvirus types 1 and 2. Nat New Biol. 1973 Jun 27;243(130):264–266. doi: 10.1038/newbio243264a0. [DOI] [PubMed] [Google Scholar]
  17. Collard W., Thornton H., Mizell M., Green M. Virus-free adenocarcinoma of the frog (summer phase tumor) transcribes Lucké tumor herpesvirus-specific RNA. Science. 1973 Aug 3;181(4098):448–449. doi: 10.1126/science.181.4098.448. [DOI] [PubMed] [Google Scholar]
  18. Darai G., Munk K. Human embryonic lung cells abortively infected with Herpes virus hominis type 2 show some properties of cell transformation. Nat New Biol. 1973 Feb 28;241(113):268–269. doi: 10.1038/newbio241268a0. [DOI] [PubMed] [Google Scholar]
  19. Deinhardt F., Falk L. A., Wolfe L. G. Simian herpesviruses. Cancer Res. 1973 Jun;33(6):1424–1426. [PubMed] [Google Scholar]
  20. Duff R., Doller E., Rapp F. Immunologic manipulation of metastases due to herpesvirus transformed cells. Science. 1973 Apr 6;180(4081):79–81. doi: 10.1126/science.180.4081.79. [DOI] [PubMed] [Google Scholar]
  21. Duff R., Rapp F. Properties of hamster embryo fibroblasts transformed in vitro after exposure to ultraviolet-irradiated herpes simplex virus type 2. J Virol. 1971 Oct;8(4):469–477. doi: 10.1128/jvi.8.4.469-477.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Epstein M. A., Achong B. G. Various forms of Epstein-Barr virus infection in man: established facts and a general concept. Lancet. 1973 Oct 13;2(7833):836–839. doi: 10.1016/s0140-6736(73)90874-x. [DOI] [PubMed] [Google Scholar]
  23. FAWCETT D. W. Electron microscope observations on intracellular virus-like particles associated with the cells of the Lucké renal adenocarcinoma. J Biophys Biochem Cytol. 1956 Nov 25;2(6):725–741. doi: 10.1083/jcb.2.6.725. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Falk L. A., Wolfe L. G., Hoekstra J., Deinhardt F. Demonstration of Herpesvirus saimiri-associated antigens in peripheral lymphocytes from infected marmosets during in vitro cultivation. J Natl Cancer Inst. 1972 Feb;48(2):523–530. [PubMed] [Google Scholar]
  25. Feorino P. M., Palmer E. L. Incidence of antibody to envelope antigen of herpes simplex virus type 2 among patients with cervical carcinoma and matched controls. J Infect Dis. 1973 Jun;127(6):732–735. doi: 10.1093/infdis/127.6.732. [DOI] [PubMed] [Google Scholar]
  26. Frenkel N., Roizman B., Cassai E., Nahmias A. A DNA fragment of Herpes simplex 2 and its transcription in human cervical cancer tissue. Proc Natl Acad Sci U S A. 1972 Dec;69(12):3784–3789. doi: 10.1073/pnas.69.12.3784. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Friedrich E. G., Jr Relief for Herpes vulvitis. Obstet Gynecol. 1973 Jan;41(1):74–77. [PubMed] [Google Scholar]
  28. Gerber P. Activation of Epstein-Barr virus by 5-bromodeoxyuridine in "virus-free" human cells (complement-fixing antigen-immunofluorescence-leukocytes). Proc Natl Acad Sci U S A. 1972 Jan;69(1):83–85. doi: 10.1073/pnas.69.1.83. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Gerber P., Monroe J. H. Studies on leukocytes growing in continuous culture derived from normal human donors. J Natl Cancer Inst. 1968 Apr;40(4):855–866. [PubMed] [Google Scholar]
  30. Gerper P., Whang-Peng J., Monroe J. H. Transformation and chromosome changes induced by Epstein-Barr virus in normal human leukocyte cultures. Proc Natl Acad Sci U S A. 1969 Jul;63(3):740–747. doi: 10.1073/pnas.63.3.740. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Glaser R., Rapp F. Rescue of Epstein-Barr virus from somatic cell hybrids of Burkitt lymphoblastoid cells. J Virol. 1972 Aug;10(2):288–296. doi: 10.1128/jvi.10.2.288-296.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Golden H. D., Chang R. S., Lou J. J., Cooper T. Y. A filterable agent in throat washings of patients with infectious mononucleosis. J Infect Dis. 1971 Oct;124(4):422–424. doi: 10.1093/infdis/124.4.422. [DOI] [PubMed] [Google Scholar]
  33. Gravell M. Viruses and renal carcinoma of Rana pipiens. X. Comparison of herpes-type viruses associated with Lucké tumor-bearing frogs. Virology. 1971 Mar;43(3):730–733. doi: 10.1016/0042-6822(71)90301-1. [DOI] [PubMed] [Google Scholar]
  34. Grose C., Feorino P. M. Epstein-Barr virus and Guillain-Barré syndrome. Lancet. 1972 Dec 16;2(7790):1285–1287. doi: 10.1016/s0140-6736(72)92654-2. [DOI] [PubMed] [Google Scholar]
  35. Hampar B., Derge J. G., Martos L. M., Walker J. L. Synthesis of Epstein-Barr virus after activation of the viral genome in a "virus-negative" human lymphoblastoid cell (Raji) made resistant to 5-bromodeoxyuridine (thymidine kinase-virus antigen-immunofluorescence-herpesvirus fingerprints). Proc Natl Acad Sci U S A. 1972 Jan;69(1):78–82. doi: 10.1073/pnas.69.1.78. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Hinze H. C. Induction of lymphoid hyperplasia and lymphoma-like disease in rabbits by Herpesvirus sylvilagus. Int J Cancer. 1971 Nov 15;8(3):514–522. doi: 10.1002/ijc.2910080320. [DOI] [PubMed] [Google Scholar]
  37. Hinze H. C., Wegner D. L. Oncogenicity of rabbit herpesvirus. Cancer Res. 1973 Jun;33(6):1434–1435. [PubMed] [Google Scholar]
  38. Hirshaut Y., Cohen M. H., Stevens D. A. Epstein-Barr-virus antibodies in American and African Burkitt's lymphoma. Lancet. 1973 Jul 21;2(7821):114–116. doi: 10.1016/s0140-6736(73)93061-4. [DOI] [PubMed] [Google Scholar]
  39. Hollinshead A. C., Lee O., Chretien P. B., Tarpley J. L., Rawls W. E., Adam E. Antibodies to herpesvirus nonvirion antigens in squamous carcinomas. Science. 1973 Nov 16;182(4113):713–715. doi: 10.1126/science.182.4113.713. [DOI] [PubMed] [Google Scholar]
  40. Hollinshead A. C., Tarro G. Soluble membrane antigens of lip and cervical carcinomas: reactivity with antibody for herpesvirus nonvirion antigens. Science. 1973 Feb 16;179(4074):698–700. doi: 10.1126/science.179.4074.698. [DOI] [PubMed] [Google Scholar]
  41. Hsiung G. D., Fong C. K., Lam K. M. In vitro transformation of leukocytes with a guinea pig herpes-like virus. Bibl Haematol. 1973;39:401–409. doi: 10.1159/000427869. [DOI] [PubMed] [Google Scholar]
  42. Hsiung G. D., Kaplow L. S. Herpeslike virus isolated from spontaneously degenerated tissue culture derived from leukemia-susceptible guinea pigs. J Virol. 1969 Mar;3(3):355–357. doi: 10.1128/jvi.3.3.355-357.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Jeor S. C., Albrecht T. B., Funk F. D., Rapp F. Stimulation of cellular DNA synthesis by human cytomegalovirus. J Virol. 1974 Feb;13(2):353–362. doi: 10.1128/jvi.13.2.353-362.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Klein G. Herpesviruses and oncogenesis. Proc Natl Acad Sci U S A. 1972 Apr;69(4):1056–1064. doi: 10.1073/pnas.69.4.1056. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Klein G., Pearson G., Rabson A., Ablashi D. V., Falk L., Wolfe L., Dienhardt F., Rabin H. Antibody reactions to herpesvirus saimiri (HVS)-induced early and late antigens (EA and LA) in HVS-infected squirrel, marmoset and owl monkeys. Int J Cancer. 1973 Jul 15;12(1):270–289. doi: 10.1002/ijc.2910120128. [DOI] [PubMed] [Google Scholar]
  46. Kufe D., Magrath I. T., Ziegler J. L., Spiegelman S. Burkitt's tumors contain particles encapsulating RNA-instructed DNA polymerase and high molecular weight virus-related RNA. Proc Natl Acad Sci U S A. 1973 Mar;70(3):737–741. doi: 10.1073/pnas.70.3.737. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. LUCKE B. Kidney carcinoma in the leopard frog: a virus tumor. Ann N Y Acad Sci. 1952 Jul 10;54(6):1093–1109. doi: 10.1111/j.1749-6632.1952.tb39981.x. [DOI] [PubMed] [Google Scholar]
  48. London W. T., Catalano L. W., Jr, Nahmias A. J., Fuccillo D. A., Sever J. L. Genital herpesvirus hominis Type 2 infection of monkeys. Obstet Gynecol. 1971 Apr;37(4):501–passim. [PubMed] [Google Scholar]
  49. Lunger P. D., Darlington R. W., Granoff A. Cell-virus relationships in the Lucké renal adenocarcinoma: an ultrastructure study. Ann N Y Acad Sci. 1965 Aug 10;126(1):289–314. doi: 10.1111/j.1749-6632.1965.tb14281.x. [DOI] [PubMed] [Google Scholar]
  50. McDougall J. K., Harnden D. G. Letter: Vaccination against cytomegalovirus? Lancet. 1974 Jan 26;1(7848):135–136. doi: 10.1016/s0140-6736(74)92368-x. [DOI] [PubMed] [Google Scholar]
  51. Melendez L. V., Daniel M. D., Hunt R. D., Garcia F. G. An apparently new herpesvirus from primary kidney cultures of the squirrel monkey (Saimiri sciureus). Lab Anim Care. 1968 Jun;18(3):374–381. [PubMed] [Google Scholar]
  52. Melendez L. V., Hunt R. D., King N. W., Barahona H. H., Daniel M. D., Fraser C. E., Garcia F. G. Herpesvirus ateles, a new lymphoma virus of monkeys. Nat New Biol. 1972 Feb 9;235(58):182–184. doi: 10.1038/newbio235182b0. [DOI] [PubMed] [Google Scholar]
  53. Melèndez L. V., Hunt R. D., Daniel M. D., Fraser C. E., Barahona H. H., King N. W., Garcìa F. G. Herpesviruses saimiri and ateles--their role in malignant lymphomas of monkeys. Fed Proc. 1972 Nov-Dec;31(6):1643–1650. [PubMed] [Google Scholar]
  54. Miller G., Lipman M. Release of infectious Epstein-Barr virus by transformed marmoset leukocytes. Proc Natl Acad Sci U S A. 1973 Jan;70(1):190–194. doi: 10.1073/pnas.70.1.190. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Mizell M., Stackpole C. W., Halperen S. Herpes-type virus recovery from "virus-free" frog kidney tumors. Proc Soc Exp Biol Med. 1968 Mar;127(3):808–814. doi: 10.3181/00379727-127-32809. [DOI] [PubMed] [Google Scholar]
  56. Moore D. H. Possible viral aetiology of human breast cancer. Br J Cancer. 1973 Jul;28(1):88–89. doi: 10.1038/bjc.1973.115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Munyon W., Kraiselburd E., Davis D., Mann J. Transfer of thymidine kinase to thymidine kinaseless L cells by infection with ultraviolet-irradiated herpes simplex virus. J Virol. 1971 Jun;7(6):813–820. doi: 10.1128/jvi.7.6.813-820.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Muñoz N. Effect of herpesvirus type 2 and hormonal imbalance on the uterine cervix of the mouse. Cancer Res. 1973 Jun;33(6):1504–1508. [PubMed] [Google Scholar]
  59. Nahmias A. J., Dowdle W. R. Antigenic and biologic differences in herpesvirus hominis. Prog Med Virol. 1968;10:110–159. [PubMed] [Google Scholar]
  60. Nahmias A. J., London W. T., Catalano L. W., Fuccillo D. A., Sever J. L., Graham C. Genital herpesvirus hominis type 2 infection: an experimental model in cebus monkeys. Science. 1971 Jan 22;171(3968):297–298. doi: 10.1126/science.171.3968.297. [DOI] [PubMed] [Google Scholar]
  61. Nayak D. P. Activation of guinea pig herpesvirus antigen in leukemic lymphoblasts of guinea pig. J Virol. 1972 Nov;10(5):933–936. doi: 10.1128/jvi.10.5.933-936.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  62. Nayak D. P. Isolation and characterization of a herpesvirus from leukemic guinea pigs. J Virol. 1971 Oct;8(4):579–588. doi: 10.1128/jvi.8.4.579-588.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  63. Nazerian K. Oncogenesis of Marek's disease. Cancer Res. 1973 Jun;33(6):1427–1430. [PubMed] [Google Scholar]
  64. Nazerian K., Solomon J. J., Witter R. L., Burmester B. R. Studies on the etiology of Marek's disease. II. Finding of a herpesvirus in cell culture. Proc Soc Exp Biol Med. 1968 Jan;127(1):177–182. doi: 10.3181/00379727-127-32650. [DOI] [PubMed] [Google Scholar]
  65. Nazerian K., Witter R. L. Cell-free transmission and in vivo replication of Marek's disease virus. J Virol. 1970 Mar;5(3):388–397. doi: 10.1128/jvi.5.3.388-397.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Nilsson K., Klein G., Henle W., Henle G. The establishment of lymphoblastoid lines from adult and fetal human lymphoid tissue and its dependence on EBV. Int J Cancer. 1971 Nov 15;8(3):443–450. doi: 10.1002/ijc.2910080312. [DOI] [PubMed] [Google Scholar]
  67. Nonoyama M., Huang C. H., Pagano J. S., Klein G., Singh S. DNA of Epstein-Barr virus detected in tissue of Burkitt's lymphoma and nasopharyngeal carcinoma. Proc Natl Acad Sci U S A. 1973 Nov;70(11):3265–3268. doi: 10.1073/pnas.70.11.3265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Nonoyama M., Pagano J. S. Separation of Epstein-Barr virus DNA from large chromosomal DNA in non-virus-producing cells. Nat New Biol. 1972 Aug 9;238(84):169–171. doi: 10.1038/newbio238169a0. [DOI] [PubMed] [Google Scholar]
  69. Okazaki W., Purchase H. G., Burmester B. R. Protection against Marek's disease by vaccination with a herpesvirus of turkeys. Avian Dis. 1970 May;14(2):413–429. [PubMed] [Google Scholar]
  70. Pagano J. S., Huang C. H., Levine P. Absence of Epstein-Barr viral DNA in Amercian Burkitt's lymphoma. N Engl J Med. 1973 Dec 27;289(26):1395–1399. doi: 10.1056/NEJM197312272892604. [DOI] [PubMed] [Google Scholar]
  71. Pagano J. S., Huang E. S. Letter: Vaccination against cytomegalovirus? Lancet. 1974 Feb 23;1(7852):316–317. doi: 10.1016/s0140-6736(74)92629-4. [DOI] [PubMed] [Google Scholar]
  72. Pereira M. S., Field A. M., Blake J. M., Rodgers F. G., Bailey L. A., Davies J. R. Evidence for oral excretion of E.B. virus in infectious mononucleosis. Lancet. 1972 Apr 1;1(7753):710–711. doi: 10.1016/s0140-6736(72)90229-2. [DOI] [PubMed] [Google Scholar]
  73. Peters W. P., Kufe D., Schlom J., Frankel J. W., Prickett C. O., Groupé V., Spiegelman S. Biological and biochemical evidence for an interaction between Marek's disease herpesvirus and avian leukosis virus in vivo. Proc Natl Acad Sci U S A. 1973 Nov;70(11):3175–3178. doi: 10.1073/pnas.70.11.3175. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Pike M. C., Morrow R. H., Kisuule A., Mafigiri J. Burkitt's lymphoma and sickle cell trait. Br J Prev Soc Med. 1970 Feb;24(1):39–41. doi: 10.1136/jech.24.1.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Pope J. H., Horne M. K., Scott W. Transformation of foetal human keukocytes in vitro by filtrates of a human leukaemic cell line containing herpes-like virus. Int J Cancer. 1968 Nov 15;3(6):857–866. doi: 10.1002/ijc.2910030619. [DOI] [PubMed] [Google Scholar]
  76. Rabson A. S., O'Conor G. T., Lorenz D. E., Kirschstein R. L., Legallais F. Y., Tralka T. S. Lymphoid cell-culture line derived from lymph node of marmoset infected wtih Herpesvirus saimiri--preliminary report. J Natl Cancer Inst. 1971 May;46(5):1099–1109. [PubMed] [Google Scholar]
  77. Rafferty K. A., Jr The cultivation of inclusion-associated viruses from Lucké tumor frogs. Ann N Y Acad Sci. 1965 Aug 10;126(1):3–21. doi: 10.1111/j.1749-6632.1965.tb14266.x. [DOI] [PubMed] [Google Scholar]
  78. Rapp F., Li J. L., Jerkofsky M. Transformation of mammalian cells by DNA-containing viruses following photodynamic inactivation. Virology. 1973 Oct;55(2):339–346. doi: 10.1016/0042-6822(73)90173-6. [DOI] [PubMed] [Google Scholar]
  79. Rawls W. E., Adam E., Melnick J. L. An analysis of seroepidemiological studies of herpesvirus type 2 and carcinoma of the cervix. Cancer Res. 1973 Jun;33(6):1477–1482. [PubMed] [Google Scholar]
  80. Rawls W. E., Tompkins W. A., Melnick J. L. The association of herpesvirus type 2 and carcinoma of the uterine cervix. Am J Epidemiol. 1969 May;89(5):547–554. doi: 10.1093/oxfordjournals.aje.a120967. [DOI] [PubMed] [Google Scholar]
  81. Reedman B. M., Klein G. Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines. Int J Cancer. 1973 May;11(3):499–520. doi: 10.1002/ijc.2910110302. [DOI] [PubMed] [Google Scholar]
  82. Royston I., Aurelian L. Immunofluorescent detection of herpesvirus antigens in exfoliated cells from human cervical carcinoma. Proc Natl Acad Sci U S A. 1970 Sep;67(1):204–212. doi: 10.1073/pnas.67.1.204. [DOI] [PMC free article] [PubMed] [Google Scholar]
  83. Sabin A. B., Tarro G. Herpes simplex and herpes genitalis viruses in etiology of some human cancers. Proc Natl Acad Sci U S A. 1973 Nov;70(11):3225–3229. doi: 10.1073/pnas.70.11.3225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  84. Skinner M. S., Mizell M. The effect of different temperatures on herpesvirus induction and replication in Lucké tumor explants. Lab Invest. 1972 Jun;26(6):671–681. [PubMed] [Google Scholar]
  85. Solomon J. J., Witter R. L., Nazerian K., Burmester B. R. Studies on the etiology of Marek's disease. I. Propagation of the agent in cell culture. Proc Soc Exp Biol Med. 1968 Jan;127(1):173–177. doi: 10.3181/00379727-127-32649. [DOI] [PubMed] [Google Scholar]
  86. Stackpole C. W. Herpes-type virus of the frog renal adenocarcinoma. I. Virus development in tumor transplants maintained at low temperature. J Virol. 1969 Jul;4(1):75–93. doi: 10.1128/jvi.4.1.75-93.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  87. Tarro G., Sabin A. B. Virus-specific, labile, nonvirion antigen in herpesvirus-infected cells. Proc Natl Acad Sci U S A. 1970 Mar;65(3):753–760. doi: 10.1073/pnas.65.3.753. [DOI] [PMC free article] [PubMed] [Google Scholar]
  88. Van der Maaten M. J., Boothe A. D. Isolation of a herpes-like virus from lymphosarcomatous cattle. Arch Gesamte Virusforsch. 1972;37(1):85–96. doi: 10.1007/BF01241154. [DOI] [PubMed] [Google Scholar]
  89. Wolfe L. G., Falk L. A., Deinhardt F. Oncogenicity of herpesvirus saimiri in marmoset monkeys. J Natl Cancer Inst. 1971 Nov;47(5):1145–1162. [PubMed] [Google Scholar]
  90. Zimmerman J. E., Jr, Glaser R., Rapp F. Effect of dibutyryl cyclic AMP on the induction of Epstein-Barr virus in hybrid cells. J Virol. 1973 Dec;12(6):1442–1445. doi: 10.1128/jvi.12.6.1442-1445.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. Zur Hausen H., Schulte-Holthausen H. Presence of EB virus nucleic acid homology in a "virus-free" line of Burkitt tumour cells. Nature. 1970 Jul 18;227(5255):245–248. doi: 10.1038/227245a0. [DOI] [PubMed] [Google Scholar]
  92. zur Hansen H., Diehl V., Wolf H., Schulte-Holthausen H., Schneider U. Occurrence of Epstein-Barr virus genomes in human lymphoblastoid cell lines. Nat New Biol. 1972 Jun 7;237(75):189–190. doi: 10.1038/newbio237189a0. [DOI] [PubMed] [Google Scholar]

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