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. 1997 Jan;71(1):797–799. doi: 10.1128/jvi.71.1.797-799.1997

In vivo administration of interleukin-2 protects susceptible mice from Theiler's virus persistence.

E L Larsson-Sciard 1, S Dethlefs 1, M Brahic 1
PMCID: PMC191120  PMID: 8985419

Abstract

In vivo administration of interleukin-2 (IL-2)-secreting tumor cells results in complete protection against persistent infection by Theiler's murine encephalomyelitis virus (TMEV) in susceptible DBA/2 mice. The IL-2-mediated protection was found to depend on the inoculum size as well as the timing of IL-2 administration. IL-2-treated and TMEV-infected mice displayed a three- to fourfold relative increase in virus-specific cytotoxic T-lymphocyte (CTL) precursors. Thus, we postulate that the persistence of TMEV infection in susceptible mice reflects limited numbers of relevant CTL precursors and their time course of induction and activation.

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Selected References

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