Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1975 Feb;78(2):285–296.

Effects of renal lymphatic occlusion and venous constriction on renal function.

J Stolarczyk, F A Carone
PMCID: PMC1912464  PMID: 1122006

Abstract

The effects of renal lymphatic occlusion or increased lymph flow due to renal vein constriction on renal function were investigated in rats. In each experiment, the renal lymphatics or vein of the left kidney were occluded or constricted and the right kidney served as a control. Occlusion of renal lymphatics caused renal enlargement, no change in glomerular filtration rate, a marked increase in urine flow and solute excretion without any change in urine osmolality, and enhanced urinary loss of urea, potassium, sodium and ammonium. Urea concentrations in medullary and papillary tissues were significantly elevated. Renal vein constriction caused renal enlargement and a marked drop in glomerular filtration rate, urine volume, urine osmolality and solute excretion. tissue concentrations of urea and potassium were decreased in the medulla and papilla and total tissue solute was significantly decreased in the papilla. The data indicate that in the rat, renal lymphatic occlusion traps urea in the medulla and induces a urea diuresis resulting in a large flow of normally concentrated urine. On the other hand, increased lymph flow secondary to renal vein constriction decreases medullary urea and potassium concentrations and papillary osmolality. These changes and the reduced glomerular filtration rate result in a small flow if dilute urine. Thus both renal lymphatic occlusion and enhanced lymph flow have a significant effect on renal function.

Full text

PDF
285

Images in this article

295Fig 1
on p.295

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOYLAN J. W., ASSHAUER E. Depletion and restoration of the medullary osmotic gradient in the dog kidney. Pflugers Arch Gesamte Physiol Menschen Tiere. 1962;276:99–116. doi: 10.1007/BF00363327. [DOI] [PubMed] [Google Scholar]
  2. Bell R. D., Keyl M. J., Shrader F. R. Effects of renal medullary concentrating ability on canine renal lymph composition. Am J Physiol. 1969 Apr;216(4):704–706. doi: 10.1152/ajplegacy.1969.216.4.704. [DOI] [PubMed] [Google Scholar]
  3. GOODWIN W. E., KAUFMAN J. J. The renal lymphatics. I. Review of some of the pertinent literature. Urol Surv. 1956 Oct;6(5):305–329. [PubMed] [Google Scholar]
  4. Henry L. P., Keyl M. J., Bell R. D. Flow and protein concentration of capsular renal lymph in the conscious dog. Am J Physiol. 1969 Aug;217(2):411–413. doi: 10.1152/ajplegacy.1969.217.2.411. [DOI] [PubMed] [Google Scholar]
  5. Honda N., Aizawa C., Morikawa A., Yoshitoshi Y. Effect of elevated ureteral pressure on renal medullary osmolal concentration in hydropenic rabbits. Am J Physiol. 1971 Sep;221(3):698–703. doi: 10.1152/ajplegacy.1971.221.3.698. [DOI] [PubMed] [Google Scholar]
  6. Honda N., Aizawa C., Morikawa A., Yoshitoshi Y. Effect of elevated venous pressure on medullary osmolar gradient in rabbit kidney. Am J Physiol. 1970 Mar;218(3):708–713. doi: 10.1152/ajplegacy.1970.218.3.708. [DOI] [PubMed] [Google Scholar]
  7. JAENIKE J. R., BRAY G. A. Effects of acute transitory urinary obstruction in the dog. Am J Physiol. 1960 Dec;199:1219–1222. doi: 10.1152/ajplegacy.1960.199.6.1219. [DOI] [PubMed] [Google Scholar]
  8. KATZ Y. J., COCKETT A. T. Elevation of inferior vena cava pressure and thoracic lymph and urine flow. Circ Res. 1959 Jan;7(1):118–122. doi: 10.1161/01.res.7.1.118. [DOI] [PubMed] [Google Scholar]
  9. Keyl M. J., Scott J. B., Dabney J. M., Haddy F. J., Harvey R. B., Bell R. D., Ginn H. E. Composition of canine renal hilar lymph. Am J Physiol. 1965 Nov;209(5):1031–1033. doi: 10.1152/ajplegacy.1965.209.5.1031. [DOI] [PubMed] [Google Scholar]
  10. Kriz W., Dieterich H. J. Das Lymphagefässsystem der Niere bei einigen Säugetieren. Licht- und elektronenmikroskopische Untersuchungen. Z Anat Entwicklungsgesch. 1970;131(2):111–147. [PubMed] [Google Scholar]
  11. LASSITER W. E., GOTTSCHALK C. W., MYLLE M. Micropuncture study of net transtubular movement of water and urea in nondiuretic mammalian kidney. Am J Physiol. 1961 Jun;200:1139–1147. doi: 10.1152/ajplegacy.1961.200.6.1139. [DOI] [PubMed] [Google Scholar]
  12. LEBRIE S. J., MAYERSON H. S. Composition of renal lymph and its significance. Proc Soc Exp Biol Med. 1959 Feb;100(2):378–380. doi: 10.3181/00379727-100-24633. [DOI] [PubMed] [Google Scholar]
  13. LEBRIE S. J., MAYERSON H. S. Influence of elevated venous pressure on flow and composition of renal lymph. Am J Physiol. 1960 May;198:1037–1040. doi: 10.1152/ajplegacy.1960.198.5.1037. [DOI] [PubMed] [Google Scholar]
  14. MAYERSON H. S. The lymphatic system with particular reference to the kidney. Surg Gynecol Obstet. 1963 Mar;116:259–272. [PubMed] [Google Scholar]
  15. MURPHY J. J., MYINT M. K., RATTNER W. H., KLAUS R., SHALLOW J. The lymphatic system of the kidney. J Urol. 1958 Jul;80(1):1–6. doi: 10.1016/S0022-5347(17)66118-4. [DOI] [PubMed] [Google Scholar]
  16. Rojo-Ortega J. M., Yeghiayan E., Genest J. Lymphatic capillaries in the renal cortex of the rat. An electron microscopic study. Lab Invest. 1973 Sep;29(3):336–341. [PubMed] [Google Scholar]
  17. SELIGSON D., SELIGSON H. A microdiffusion method for the determination of nitrogen liberated as ammonia. J Lab Clin Med. 1951 Aug;38(2):324–330. [PubMed] [Google Scholar]
  18. SWANN H. G., ORMSBY A. A., DELASHAW J. B., THARP W. W. Relation of lymph to distending fluids of the kidney. Proc Soc Exp Biol Med. 1958 Mar;97(3):517–522. doi: 10.3181/00379727-97-23792. [DOI] [PubMed] [Google Scholar]
  19. SWANN H. G., ORMSBY A. A., DELASHAW J. B., THARP W. W. Relation of lymph to distending fluids of the kidney. Proc Soc Exp Biol Med. 1958 Mar;97(3):517–522. doi: 10.3181/00379727-97-23792. [DOI] [PubMed] [Google Scholar]
  20. TORMENE A., MILLINTHEI R., ZANGRANDO O. THE ROLE OF THE LYMPHATIC SYSTEM OF THE KIDNEY IN PHYSIOPATHOLOGY OF URETERAL OBSTRUCTION. Urol Int. 1963;16:341–352. doi: 10.1159/000279095. [DOI] [PubMed] [Google Scholar]
  21. ULLRICH K. J., KRAMER K., BOYLAN J. W. Present knowledge of the counter-current system in the mammalian kidney. Prog Cardiovasc Dis. 1961 Mar;3:395–431. doi: 10.1016/s0033-0620(61)80001-7. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES