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. 1975 Feb;78(2):297–308.

Experimental hypertension. The effects of chemical ablation of the renal papilla on the blood pressure of rats with and without silver-clip hypertension.

R H Heptinstall, D C Salyer, W R Salyer
PMCID: PMC1912469  PMID: 1122007

Abstract

Because of the ease with which ablation of the renal papilla of the rat can be effected by chemical means, a study was carried out to determine the effects of this ablation on the blood pressure. Significant elevation was found, lennding support to the idea of the antihypertensive role of the renal medulla. Constriction of one renal artery of rats with their papillae removed resulted in a more rapid and greater elevation of pressure than the same procedure in rats ith their papillae intact. The rise in pressure approximated the sum of the rises caused by removal of the papilla alone and by renal artery constriction alone, consistent with the idea of two mechanisms being at work in this model.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anggård E., Bohman S. O., Griffin J. E., 3rd, Larsson C., Maunsbach A. B. Subcellular localization of the prostaglandin system in the rabbit renal papilla. Acta Physiol Scand. 1972 Feb;84(2):231–246. doi: 10.1111/j.1748-1716.1972.tb05174.x. [DOI] [PubMed] [Google Scholar]
  2. Brunner H. R., Kirshman J. D., Sealey J. E., Laragh J. H. Hypertension of renal origin: evidence for two different mechanisms. Science. 1971 Dec 24;174(4016):1344–1346. doi: 10.1126/science.174.4016.1344. [DOI] [PubMed] [Google Scholar]
  3. Crowshaw K., McGiff J. C., Strand J. C., Lonigro A. J., Terrangno N. A. Prostaglandins in dog renal medulla. J Pharm Pharmacol. 1970 Apr;22(4):302–304. doi: 10.1111/j.2042-7158.1970.tb08523.x. [DOI] [PubMed] [Google Scholar]
  4. Daniels E. G., Hinman J. W., Leach B. E., Muirhead E. E. Identification of prostaglandin E2 as the principal vasodepressor lipid of rabbit renal medulla. Nature. 1967 Sep 16;215(5107):1298–1299. doi: 10.1038/2151298a0. [DOI] [PubMed] [Google Scholar]
  5. FLOYER M. A. Further studies on the mechanism of experimental hypertension in the rat. Clin Sci. 1955 May;14(2):163–181. [PubMed] [Google Scholar]
  6. FLOYER M. A. The effect of nephrectomy and adrenalectomy upon the blood pressure in hypertensive and normotensive rats. Clin Sci. 1951 Nov;10(4):405–421. [PubMed] [Google Scholar]
  7. GOMEZ A. H., HOOBLER S. W., BLAQUIER P. Effect of addition and removal of a kidney transplant in renal and adrenocortical hypertensive rats. Circ Res. 1960 Mar;8:464–472. doi: 10.1161/01.res.8.2.464. [DOI] [PubMed] [Google Scholar]
  8. GROSS F., SCHAECHTELIN G., BRUNNER H., PETERS G. THE ROLE OF THE RENIN-ANGIOTENSIN SYSTEM IN BLOOD PRESSURE REGULATION AND KIDNEY FUNCTION. Can Med Assoc J. 1964 Jan 25;90:258–262. [PMC free article] [PubMed] [Google Scholar]
  9. Heptinstall R. H. The role of the juxtaglomerular apparatus in experimental renal hypertension in the rat. Lab Invest. 1965 Dec;14(12):2150–2159. [PubMed] [Google Scholar]
  10. Krieger E. M., Salgado H. C., Assan C. J. Greene LL, Ferreira SH: Potential screening test for detection of overactivity of renin-angiotensin system. Lancet. 1971 Feb 6;1(7693):269–271. doi: 10.1016/s0140-6736(71)91005-1. [DOI] [PubMed] [Google Scholar]
  11. LEE J. B., COVINO B. G., TAKMAN B. H., SMITH E. R. RENOMEDULLARY VASODEPRESSOR SUBSTANCE, MEDULLIN: ISOLATION, CHEMICAL CHARACTERIZATION AND PHYSIOLOGICAL PROPERTIES. Circ Res. 1965 Jul;17:57–77. doi: 10.1161/01.res.17.1.57. [DOI] [PubMed] [Google Scholar]
  12. LEE J. B., HICKLER R. B., SARAVIS C. A., THORN G. W. SUSTAINED DEPRESSOR EFFECT OF RENAL MEDULLARY EXTRACT IN THE NORMOTENSIVE RAT. Circ Res. 1963 Oct;13:359–366. doi: 10.1161/01.res.13.4.359. [DOI] [PubMed] [Google Scholar]
  13. Lee J. B. Cardiovascular-renal effects of prostaglandins: the antihypertensive, natriuretic renal "endocrine" function. Arch Intern Med. 1974 Jan;133(1):56–76. [PubMed] [Google Scholar]
  14. MUIRHEAD E. E., JONES F., STIRMAN J. A. Antihypertensive property in renoprival hypertension of extract from renal medulla. J Lab Clin Med. 1960 Aug;56:167–180. [PubMed] [Google Scholar]
  15. Macdonald G. J., Louis W. J., Renzini V., Boyd G. W., Peart W. S. Renal-clip hypertension in rabbits immunized against angiotensin II. Circ Res. 1970 Aug;27(2):197–211. doi: 10.1161/01.res.27.2.197. [DOI] [PubMed] [Google Scholar]
  16. Muehrcke R. C., Mandal A. K., Epstein M., Volini F. I. Cytoplasmic granularity of the renal medullary interstitial cells in experimental hypertension. J Lab Clin Med. 1969 Feb;73(2):299–308. [PubMed] [Google Scholar]
  17. Muirhead E. E., Brooks B., Kosinski M., Daniels E. G., Hinman J. W. Renomedullary antihypertensive principle in renal hypertension. J Lab Clin Med. 1966 May;67(5):778–791. [PubMed] [Google Scholar]
  18. Muirhead E. E., Brooks B., Pitcock J. A., Stephenson P. Renomedullary antihypertensive function in accelerated (malignant) hypertension. Observations on renomedullary interstitial cells. J Clin Invest. 1972 Jan;51(1):181–190. doi: 10.1172/JCI106790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Muirhead E. E., Brown G. B., Germain G. S., Leach B. E. The renal medulla as an antihypertensive organ. J Lab Clin Med. 1970 Oct;76(4):641–651. [PubMed] [Google Scholar]
  20. Muirhead E. E., Germain G., Leach B. E., Pitcock J. A., Stephenson P., Brooks B., Brosius W. L., Daniels E. G., Hinman J. W. Production of renomedullary prostaglandins by renomedullary interstitial cells grown in tissue culture. Circ Res. 1972 Sep;31(9 Suppl):161–172. [PubMed] [Google Scholar]
  21. Murray G., Wyllie R. G., Hill G. S., Ramsden P. W., Heptinstall R. H. Experimental papillary necrosis of the kidney. I. Morphologic and functional data. Am J Pathol. 1972 May;67(2):285–302. [PMC free article] [PubMed] [Google Scholar]
  22. Nissen H. M. On lipid droplets in renal interstitial cells. I. A histochemical study. Z Zellforsch Mikrosk Anat. 1967;83(1):76–81. doi: 10.1007/BF00334742. [DOI] [PubMed] [Google Scholar]
  23. TOBIAN L., THOMPSON J., TWEDT R., JANECEK J. The granulation of juxtaglomerular cells in renal hypertension, desoxycorticosterone and postdesoxycorticosterone hypertension, adrenal regeneration hypertension, and adrenal insufficiency. J Clin Invest. 1958 May;37(5):660–671. doi: 10.1172/JCI103651. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Tobian L., Ishii M., Duke M. Relationship of cytoplasmic granules in renal papillary interstitial cells to "postsalt" hypertension. J Lab Clin Med. 1969 Feb;73(2):309–319. [PubMed] [Google Scholar]

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