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. 1975 Mar;78(3):497–504.

Lipid accumulation in smooth muscle cell lysosomes im primate atherosclerosis.

S Goldfischer, B Schiller, H Wolinsky
PMCID: PMC1912555  PMID: 1119538

Abstract

Cytochemical and ultrastructural examination of the developing atherosclerotic lesion in hypercholesterolemic rhesus monkeys reveals that lipid is sequestered within lysosomes of aortic smooth muscle cells. A common pathway in the development of sclerotic arterial disease appears to be overloading of vascular smooth muscle cell lysosomes with a variety of metabolites. This may occur as a consequence of an excess of substrate or because of a congenital deficiency of a lysosomal hydrolase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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