Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1968 Nov 9;4(5627):360–364. doi: 10.1136/bmj.4.5627.360

Circulatory and Metabolic Effects of Oxygen in Myocardial Infarction

A C F Kenmure, W R Murdoch, A D Beattie, J C B Marshall, A J V Cameron
PMCID: PMC1912629  PMID: 5683582

Abstract

The circulatory and metabolic effects of inhalation of oxygen in high concentration were investigated in 50 patients with acute myocardial infarction. The heart rate, arterial blood pressure, cardiac out-put, blood gas tensions, pH, and lactate and pyruvate levels were measured. In general, oxygen inhalation produced a fall in cardiac output and stroke volume and a rise in blood pressure and systemic vascular resistance. In a small number of patients with very low cardiac out-puts there was a rise in output. A substantial rise in arterial oxygen tension was obtained even in patients with low initial values. The raised arterial blood lactate levels which were frequently present were reduced after oxygen. The therapeutic implications of these effects are discussed.

Full text

PDF
360

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BROCH O. J., HUMERFELT S., HAARSTAD J., MYHRE J. R. Hemodynamic studies in acute myocardial infarction. Am Heart J. 1959 Apr;57(4):522–529. doi: 10.1016/0002-8703(59)90029-8. [DOI] [PubMed] [Google Scholar]
  2. Cameron A. J., Hutton I., Kenmure A. C., Murdoch W. R. Haemodynamic and metabolic effects of hyperbaric oxygen in myocardial infarction. Lancet. 1966 Oct 15;2(7468):833–837. doi: 10.1016/s0140-6736(66)92258-6. [DOI] [PubMed] [Google Scholar]
  3. DALY W. J., BONDURANT S. Effects of oxygen breathing on the heart rate, blood pressure, and cardiac index of normal men--resting, with reactive hyperemia, and after atropine. J Clin Invest. 1962 Jan;41:126–132. doi: 10.1172/JCI104454. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DOLLERY C. T., HILL D. W., MAILER C. M., RAMALHO P. S. HIGH OXYGEN PRESSURE AND THE RETINAL BLOOD-VESSELS. Lancet. 1964 Aug 8;2(7354):291–292. doi: 10.1016/s0140-6736(64)93051-x. [DOI] [PubMed] [Google Scholar]
  5. Deane B. C., Phinney A. O., Jr, McLean C. E. The spectrophotometric determination of Coomassie blue dye by a direct serum method. J Lab Clin Med. 1966 Jan;67(1):177–180. [PubMed] [Google Scholar]
  6. GORLIN R., BRACHFELD N., MACLEOD C., BOPP P. Effect of nitroglycerin on the coronary circulation in patients with coronary artery disease or increased left ventricular work. Circulation. 1959 May;19(5):705–718. doi: 10.1161/01.cir.19.5.705. [DOI] [PubMed] [Google Scholar]
  7. HUCKABEE W. E. Relationships of pyruvate and lactate during anaerobic metabolism. I. Effects of infusion of pyruvate or glucose and of hyperventilation. J Clin Invest. 1958 Feb;37(2):244–254. doi: 10.1172/JCI103603. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MACKENZIE G. J., FLENLEY D. C., TAYLOR S. H., MCDONALD A. H., STAUNTON H. P., DONALD K. W. CIRCULATORY AND RESPIRATORY STUDIES IN MYOCARDIAL INFARCTION AND CARDIOGENIC SHOCK. Lancet. 1964 Oct 17;2(7364):825–832. doi: 10.1016/s0140-6736(64)90684-1. [DOI] [PubMed] [Google Scholar]
  9. MALMCRONA R., VARNAUSKAS E. HAEMODYNAMICS IN ACUTE MYOCARDIAL INFARCTION. Acta Med Scand. 1964 Jan;175:1–17. [PubMed] [Google Scholar]
  10. McDowall D. G., Ledingham I. M., Jacobson I., Norman J. N. Oxygen administration by mask in a pressure chamber. Anesthesiology. 1965 Nov-Dec;26(6):720–726. doi: 10.1097/00000542-196511000-00005. [DOI] [PubMed] [Google Scholar]
  11. McNicol M. W., Kirby B. J., Bhoola K. D., Everest M. E., Price H. V., Freedman S. F. Pulmonary function in acute myocardial infarction. Br Med J. 1965 Nov 27;2(5473):1270–1273. doi: 10.1136/bmj.2.5473.1270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. THOMAS M., MALMCRONA R., SHILLINGFORD J. HAEMODYNAMIC EFFECTS OF OXYGEN IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION. Br Heart J. 1965 May;27:401–407. doi: 10.1136/hrt.27.3.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. THOMAS M., MALMCRONA R., SHILLINGFORD J. HEMODYNAMIC CHANGES IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION. Circulation. 1965 Jun;31:811–823. doi: 10.1161/01.cir.31.6.811. [DOI] [PubMed] [Google Scholar]
  14. Taylor S. H., Shillingford J. P. CLINICAL APPLICATIONS OF COOMASSIE BLUE. Br Heart J. 1959 Oct;21(4):497–504. doi: 10.1136/hrt.21.4.497. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Valentine P. A., Fluck D. C., Mounsey J. P., Reid D., Shillingford J. P., Steiner R. E. Blood-gas changes after acute myocardial infarction. Lancet. 1966 Oct 15;2(7468):837–841. doi: 10.1016/s0140-6736(66)92259-8. [DOI] [PubMed] [Google Scholar]
  16. WHALEN R. E., SALTZMAN H. A., HOLLOWAY D. H., Jr, MCINTOSH H. D., SIEKER H. O., BROWN I. W., Jr CARDIOVASCULAR AND BLOOD GAS RESPONSES TO HYPERBARIC OXYGENATION. Am J Cardiol. 1965 May;15:638–646. doi: 10.1016/0002-9149(65)90350-4. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES