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. 1968 Nov 23;4(5629):477–479. doi: 10.1136/bmj.4.5629.477

Prevention of Rhesus Immunization. A Controlled Clinical Trial with a Comparatively Low Dose of Anti-D Immunoglobulin

C Dudok De Wit, E Borst-Eilers, ChM v d Weerdt, G J Kloosterman
PMCID: PMC1912672  PMID: 4177613

Abstract

A controlled clinical trial was carried out to test the effectiveness of a comparatively low dose of anti-D immunoglobulin (250 μg) in preventing rhesus immunization.

In the control group 17 out of 329 women (5%) formed rhesus antibodies, whereas in the treated group only 3 out of 333 women (0.9%) showed active immunization, all three of whom had an exceptionally large transplacental bleeding.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chown B. Placental haemorrhage after version. Lancet. 1968 Apr 6;1(7545):759–759. doi: 10.1016/s0140-6736(68)92216-2. [DOI] [PubMed] [Google Scholar]
  2. Clarke C. A. Prevention of Rh-haemolytic disease. Br Med J. 1967 Oct 7;4(5570):7–12. doi: 10.1136/bmj.4.5570.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Freda V. J., Gorman J. G., Pollack W., Robertson J. G., Jennings E. R., Sullivan J. F. Prevention of Rh isoimmunization. Progress report of the clinical trial in mothers. JAMA. 1967 Feb 6;199(6):390–394. doi: 10.1001/jama.199.6.390. [DOI] [PubMed] [Google Scholar]
  4. Hughes-Jones N. C., Mollison P. L. Failure of a Relatively Small Dose of Passively Administered Anti-Rh to Suppress Primary Immunization by a Relatively Large Dose of Rh-positive Red Cells. Br Med J. 1968 Jan 20;1(5585):150–151. doi: 10.1136/bmj.1.5585.150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. KLEIHAUER E., BRAUN H., BETKE K. Demonstration von fetalem Hämoglobin in den Erythrocyten eines Blutausstrichs. Klin Wochenschr. 1957 Jun 15;35(12):637–638. doi: 10.1007/BF01481043. [DOI] [PubMed] [Google Scholar]
  6. SCHNEIDER J., SCHOFF G. DIE FETOMATERNE MIKROTRANSFUSION WAEHREND DES GEBURTSVERLAUFS. Zentralbl Gynakol. 1964 Dec 26;86:1829–1835. [PubMed] [Google Scholar]
  7. Woodrow J. C., Bowley C. C., Gilliver B. E., Strong S. J. Prevention of Rh Immunization Due to Large Volumes of Rh-positive Blood. Br Med J. 1968 Jan 20;1(5585):148–150. doi: 10.1136/bmj.1.5585.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Zipursky A., Israels L. G. The pathogenesis and prevention of Rh immunization. Can Med Assoc J. 1967 Nov 18;97(21):1245–1257. [PMC free article] [PubMed] [Google Scholar]
  9. de Wit C. D., Borst-Eilers E. Failure of Anti-D Immunoglobulin Injection to Protect against Rhesus Immunization after Massive Foeto-maternal Haemorrhage. Report of 4 Cases. Br Med J. 1968 Jan 20;1(5585):152–154. doi: 10.1136/bmj.1.5585.152. [DOI] [PMC free article] [PubMed] [Google Scholar]

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