Abstract
Metoclopramide (N-(diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide) has been investigated with human gastrointestinal smooth-muscle preparations in vitro. Small-intestinal and colonic circular muscle was contracted by metoclopramide. This effect was antagonized by atropine. Gastric and colonic longitudinal muscle was sensitized by metoclopramide to acetylcholine. Atropine acted here as a partial antagonist of metoclopramide.
The interference of acetylcholine and metoclopramide is of a hitherto undescribed pharmacological type. The effects of metoclopramide in vivo—where its action is predominantly on the stomach and pylorus—are not fully explained by these in vitro experiments in which the effect was found to be most pronounced on the colon.
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- Bennett A., Whitney B. A pharmacological study of the motility of the human gastrointestinal tract. Gut. 1966 Aug;7(4):307–316. doi: 10.1136/gut.7.4.307. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GRIVAUX M., CORNET A., WATTEZ E. LE M'ETOCLOPRAMIDE EN RADIOLOGIE DIGESTIVE. Sem Hop. 1964 Oct 14;40:2338–2345. [PubMed] [Google Scholar]
- JUSTIN-BESANCON L., GRIVAUX M., WATTEZ E. L''EPREUVE AU M'ETOCLOPRAMIDE EN RADIOLOGIE DIGESTIVE. Bull Mem Soc Med Hop Paris. 1964 May 15;115:721–726. [PubMed] [Google Scholar]
- JUSTIN-BESANCON L. INTRODUCTION AUX RECHERCHES CLINIQUES SUR LE M'ETOCLOPRAMIDE. Sem Hop. 1964 Oct 14;40:2337–2338. [PubMed] [Google Scholar]
- JUSTIN-BESANCON L., LAVILLE C. ACTION ANTI'EM'ETIQUE DU M'ETOCLOPRAMIDE VIS-'A-VIS DE L'APOMORPHINE ET DE L'HYDERGINE. C R Seances Soc Biol Fil. 1964;158:723–727. [PubMed] [Google Scholar]
- JUSTIN-BESANCON L., LAVILLE C. ACTION DU M'ETOCLOPRAMIDE SUR LE SYST'EME NERVEUX AUTONOME. C R Seances Soc Biol Fil. 1964;158:1016–1018. [PubMed] [Google Scholar]
- JUSTIN-BESANCON L., LAVILLE C., THOMINET M. LE M'ETOCLOPRAMIDE ET SES HOMOLOGUES. INTRODUCTION 'A LEUR 'ETUDE BIOLOGIQUE. C R Hebd Seances Acad Sci. 1964 Apr 27;258:4384–4386. [PubMed] [Google Scholar]
- Jacoby H. I., Brodie D. A. Gastrointestinal actions of metoclopramide. An experimental study. Gastroenterology. 1967 Apr;52(4):676–684. [PubMed] [Google Scholar]
- Misiewicz J. J., Waller S. L., Eisner M. Motor responses of human gastrointestinal tract to 5-hydroxytryptamine in vivo and in vitro. Gut. 1966 Jun;7(3):208–216. doi: 10.1136/gut.7.3.208. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sickinger K., Fiedler E., Bokermann M., Emmrich J. Erleichterung der Duodenalund Jejunalsondierung mit einum Modifikator der Magen- und Duodenalperistaltik (Metoclopramid) Med Klin. 1965 Dec 17;60(51):2056–2057. [PubMed] [Google Scholar]