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. 1968 Dec 21;4(5633):732-3, 734-737. doi: 10.1136/bmj.4.5633.732

Gastric Ulceration Occurring during Indomethacin Therapy*

R T Taylor, E C Huskisson, G H Whitehouse, F Dudley Hart, D H Trapnell
PMCID: PMC1912892  PMID: 5723725

Abstract

Dyspeptic symptoms, gastrointestinal bleeding, or the development of anaemia without dyspepsia in patients treated with indomethacin may be manifestations of peptic ulceration. Such manifestations occur with suppositories as well as with capsules. The ulcers in the present series tended to be prepyloric, and often aroused the suspicion of malignancy. Symptoms were promptly relieved and radiological healing occurred rapidly after withdrawal of the drug.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARAGAR F. D., DUTHIE J. J. Importance of aspirin as a cause of anaemia and peptic ulcer in rheumatoid arthritis. Br Med J. 1960 Apr 9;1(5179):1106–1108. doi: 10.1136/bmj.1.5179.1106. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Boardman P. L., Hart F. D. Side-effects of indomethacin. Ann Rheum Dis. 1967 Mar;26(2):127–132. doi: 10.1136/ard.26.2.127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gibberd F. B. Dyspepsia in patients with rheumatoid arthritis. Acta Rheumatol Scand. 1966;12(2):112–121. doi: 10.3109/rhe1.1966.12.issue-1-4.13. [DOI] [PubMed] [Google Scholar]
  4. HARPER R. A., GREEN B. Malignant gastric ulcer. Clin Radiol. 1961 Apr;12:95–108. doi: 10.1016/s0009-9260(61)80069-x. [DOI] [PubMed] [Google Scholar]
  5. Hart F. D. Indomethacin and gastric ulcer. Br Med J. 1965 Oct 23;2(5468):1000–1001. doi: 10.1136/bmj.2.5468.1000-d. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. JENNINGS D., RICHARDSON J. E. Giant lesser-curve gastric ulcers. Lancet. 1954 Aug 21;267(6834):343–350. doi: 10.1016/s0140-6736(54)92660-4. [DOI] [PubMed] [Google Scholar]
  7. KERN F., Jr, CLARK G. M., LUKENS J. G. Peptic ulceration occurring during therapy for rheumatoid arthritis. Gastroenterology. 1957 Jul;33(1):25–33. [PubMed] [Google Scholar]

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