Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1975 Sep;80(3):471–480.

The relationship of actin and myosin filaments within myocardial zonal lesions.

S W Unger, N B Ratliff
PMCID: PMC1913014  PMID: 1231566

Abstract

Cross sections, including serial sections, of myocardial zonal lesions in right vetricular papillary muscles of cats subjected to hypovolemic shock were examined by electron microscopy. It was determined that the basic structure of A and I bands was retained even in severe zonal lesions with herniation of A and I bands through the intercalated disc into adjacent myocytes. The herniated A and I bands, together with accompanying mitochondria, were enclosed in membranes, apparently the unspecialized portion of the intercalated disc. Since the longitudinal orientation of myofilaments is retained in zonal lesions, this study indicates that intact A and I bands must slide past one another during the supercontraction of sarcomeres which is characteristic of zonal lesions. This study also presents evidence that the nexus may become involved in zonal lesions.

Full text

PDF
471

Images in this article

477Figure 1
on p.477
477Figure 2
on p.477
478Figure 3
on p.478
478Figure 4
on p.478
479Figure 5
on p.479
480Figure 6
on p.480

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CROWELL J. W., GUYTON A. C. Further evidence favoring a cardiac mechanism in irreversible hemorrhagic shock. Am J Physiol. 1962 Aug;203:248–252. doi: 10.1152/ajplegacy.1962.203.2.248. [DOI] [PubMed] [Google Scholar]
  2. GOMEZ O. A., HAMILTON W. F. FUNCTIONAL CARDIAC DETERIORATION DURING DEVELOPMENT OF HEMORRHAGIC CIRCULATORY DEFICIENCY. Circ Res. 1964 Apr;14:327–336. doi: 10.1161/01.res.14.4.327. [DOI] [PubMed] [Google Scholar]
  3. Goldner R. D., Ratliff N. B., Kopelman R. I., Hackel D. B. Ultrastructral effects of in virto experimentation on right ventricular papillary muscle from cats in hypovolemic shock (38487). Proc Soc Exp Biol Med. 1975 Jan;148(1):113–117. doi: 10.3181/00379727-148-38487. [DOI] [PubMed] [Google Scholar]
  4. Graham R. C., Jr, Karnovsky M. J. The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. J Histochem Cytochem. 1966 Apr;14(4):291–302. doi: 10.1177/14.4.291. [DOI] [PubMed] [Google Scholar]
  5. HACKEL D. B., GOODALE W. T. Effects of hemorrhagic shock on the heart and circulation of intact dogs. Circulation. 1955 Apr;11(4):628–634. doi: 10.1161/01.cir.11.4.628. [DOI] [PubMed] [Google Scholar]
  6. Hackel D. B., Ratliff N. B., Mikat E. The heart in shock. Circ Res. 1974 Dec;35(6):805–811. doi: 10.1161/01.res.35.6.805. [DOI] [PubMed] [Google Scholar]
  7. Kajihara H., Hara H., Seyama S., Iijima S., Yoshidoa M. Light and electron microscopic observations of the myocardium of dogs in hemorrhagic shock. Acta Pathol Jpn. 1973 May;23(2):315–333. doi: 10.1111/j.1440-1827.1973.tb00795.x. [DOI] [PubMed] [Google Scholar]
  8. Lefer A. M. Corticosteroid antagonism of the positive inotropic effect of ouabain. J Pharmacol Exp Ther. 1966 Feb;151(2):294–299. [PubMed] [Google Scholar]
  9. MARTIN A. M., Jr, HACKEL D. B., KURTZ S. M. THE ULTRASTRUCTURE OF ZONAL LESIONS OF THE MYOCARDIUM IN HEMORRHAGIC SHOCK. Am J Pathol. 1964 Jan;44:127–140. [PMC free article] [PubMed] [Google Scholar]
  10. Martin A. M., Jr, Hackel D. B. An electron microscopic study of the progression of myocardial lesions in the dog after hemorrhagic shock. Lab Invest. 1966 Jan;15(1 Pt 2):243–260. [PubMed] [Google Scholar]
  11. Peracchia C., Mittler B. S. Fixation by means of glutaraldehyde-hydrogen peroxide reaction products. J Cell Biol. 1972 Apr;53(1):234–238. doi: 10.1083/jcb.53.1.234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ratliff N. B., Hackel D. B., Mikat E. Myocardial oxygen metabolism and myocardial blood flow in dogs in hemorrhagic shock. Circ Res. 1969 Jun;24(6):901–909. doi: 10.1161/01.res.24.6.901. [DOI] [PubMed] [Google Scholar]
  13. Ratliff N. B., Hackel D. B., Mikat E. The effect of hyperbaric oxygen on the myocardial lesions of hemorrhagic shock in dogs. Am J Pathol. 1967 Sep;51(3):341–349. [PMC free article] [PubMed] [Google Scholar]
  14. Ratliff N. B., Kopelman R. I., Goldner R. D., Cruz P. T., Hackel D. B. Formation of myocardial zonal lesions. Am J Pathol. 1975 May;79(2):321–334. [PMC free article] [PubMed] [Google Scholar]
  15. Ratliff N. B. Letter to the editors: Myocardial zonal lesions and myofibrillar degeneration: the need for definition. J Mol Cell Cardiol. 1975 Mar;7(3):225–226. doi: 10.1016/0022-2828(75)90161-3. [DOI] [PubMed] [Google Scholar]
  16. Siegel H. W., Downing S. E. Reduction of left ventricular contractility during acute hemorrhagic shock. Am J Physiol. 1970 Mar;218(3):772–779. doi: 10.1152/ajplegacy.1970.218.3.772. [DOI] [PubMed] [Google Scholar]
  17. Trump B. F., Bulger R. E. New ultrastructural characteristics of cells fixed in a glutaraldehyde-osmium tetroxide mixture. Lab Invest. 1966 Jan;15(1 Pt 2):368–379. [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES