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. 1997 Mar;71(3):2547–2549. doi: 10.1128/jvi.71.3.2547-2549.1997

Reed-Sternberg cells and "bystander" lymphocytes in lymph nodes affected by Hodgkin's disease are infected with different strains of Epstein-Barr virus.

F Meggetto 1, P Brousset 1, J Selves 1, G Delsol 1, B Mariame 1
PMCID: PMC191371  PMID: 9032398

Abstract

In most cases of Epstein-Barr virus (EBV)-associated Hodgkin's disease (HD), EBV-positive Reed-Sternberg (RS) cells and rare EBV-positive reservoir lymphocytes coexist in lymph nodes. Here we show that, in two cases of EBV-associated HD, strains infecting RS cells and reservoir lymphocytes of the same patient have different BNLF-1 genes. This suggests that RS cells and reservoir lymphocytes of the same patient are infected by different EBV strains.

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Selected References

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