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. 1997 Mar;71(3):2567–2571. doi: 10.1128/jvi.71.3.2567-2571.1997

Suppression of apoptotic DNA fragmentation in herpes simplex virus type 1-infected cells.

A H Koyama 1, Y Miwa 1
PMCID: PMC191375  PMID: 9032402

Abstract

HEp-2 cells underwent apoptosis when the cells were incubated in medium containing sorbitol. Infection with herpes simplex virus type 1 (HSV-1) prior to the sorbitol treatment suppressed this apoptosis completely, indicating that HSV-1 carries an antiapoptosis gene. In addition, HSV-1 multiplication was restricted in these apoptotic HEp-2 cells.

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Selected References

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