Skip to main content
PMC home page
Journal of Virology logoLink to Journal of Virology
. 1997 Apr;71(4):2583–2590. doi: 10.1128/jvi.71.4.2583-2590.1997

Virus-encoded RNA helicases.

G Kadaré 1, A L Haenni 1
PMCID: PMC191378  PMID: 9060609

Full Text

The Full Text of this article is available as a PDF (99.4 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bayliss C. D., Smith G. L. Vaccinia virion protein I8R has both DNA and RNA helicase activities: implications for vaccinia virus transcription. J Virol. 1996 Feb;70(2):794–800. doi: 10.1128/jvi.70.2.794-800.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beck D. L., Guilford P. J., Voot D. M., Andersen M. T., Forster R. L. Triple gene block proteins of white clover mosaic potexvirus are required for transport. Virology. 1991 Aug;183(2):695–702. doi: 10.1016/0042-6822(91)90998-q. [DOI] [PubMed] [Google Scholar]
  3. Dzianott A. M., Bujarski J. J. The nucleotide sequence and genome organization of the RNA-1 segment in two bromoviruses: broad bean mottle virus and cowpea chlorotic mottle virus. Virology. 1991 Dec;185(2):553–562. doi: 10.1016/0042-6822(91)90525-g. [DOI] [PubMed] [Google Scholar]
  4. Eagles R. M., Balmori-Melián E., Beck D. L., Gardner R. C., Forster R. L. Characterization of NTPase, RNA-binding and RNA-helicase activities of the cytoplasmic inclusion protein of tamarillo mosaic potyvirus. Eur J Biochem. 1994 Sep 1;224(2):677–684. doi: 10.1111/j.1432-1033.1994.t01-1-00677.x. [DOI] [PubMed] [Google Scholar]
  5. Fauquet C. M., Martelli G. P. Updated ICTV list of names and abbreviations of viruses, viroids, and satellites infecting plants. Arch Virol. 1995;140(2):393–413. doi: 10.1007/BF01309874. [DOI] [PubMed] [Google Scholar]
  6. Fernández A., Laín S., García J. A. RNA helicase activity of the plum pox potyvirus CI protein expressed in Escherichia coli. Mapping of an RNA binding domain. Nucleic Acids Res. 1995 Apr 25;23(8):1327–1332. doi: 10.1093/nar/23.8.1327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Geider K., Hoffmann-Berling H. Proteins controlling the helical structure of DNA. Annu Rev Biochem. 1981;50:233–260. doi: 10.1146/annurev.bi.50.070181.001313. [DOI] [PubMed] [Google Scholar]
  8. Gibson T. J., Thompson J. D. Detection of dsRNA-binding domains in RNA helicase A and Drosophila maleless: implications for monomeric RNA helicases. Nucleic Acids Res. 1994 Jul 11;22(13):2552–2556. doi: 10.1093/nar/22.13.2552. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gilmer D., Bouzoubaa S., Hehn A., Guilley H., Richards K., Jonard G. Efficient cell-to-cell movement of beet necrotic yellow vein virus requires 3' proximal genes located on RNA 2. Virology. 1992 Jul;189(1):40–47. doi: 10.1016/0042-6822(92)90679-j. [DOI] [PubMed] [Google Scholar]
  10. Gorbalenya A. E., Koonin E. V., Donchenko A. P., Blinov V. M. Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Nucleic Acids Res. 1989 Jun 26;17(12):4713–4730. doi: 10.1093/nar/17.12.4713. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gorbalenya A. E., Koonin E. V. Viral proteins containing the purine NTP-binding sequence pattern. Nucleic Acids Res. 1989 Nov 11;17(21):8413–8440. doi: 10.1093/nar/17.21.8413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Gorbalenya A. E., Koonin E. V., Wolf Y. I. A new superfamily of putative NTP-binding domains encoded by genomes of small DNA and RNA viruses. FEBS Lett. 1990 Mar 12;262(1):145–148. doi: 10.1016/0014-5793(90)80175-i. [DOI] [PubMed] [Google Scholar]
  13. Grifo J. A., Abramson R. D., Satler C. A., Merrick W. C. RNA-stimulated ATPase activity of eukaryotic initiation factors. J Biol Chem. 1984 Jul 10;259(13):8648–8654. [PubMed] [Google Scholar]
  14. Gros C., Wengler G. Identification of an RNA-stimulated NTPase in the predicted helicase sequence of the Rubella virus nonstructural polyprotein. Virology. 1996 Mar 1;217(1):367–372. doi: 10.1006/viro.1996.0125. [DOI] [PubMed] [Google Scholar]
  15. Gross C. H., Shuman S. Mutational analysis of vaccinia virus nucleoside triphosphate phosphohydrolase II, a DExH box RNA helicase. J Virol. 1995 Aug;69(8):4727–4736. doi: 10.1128/jvi.69.8.4727-4736.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Gross C. H., Shuman S. The QRxGRxGRxxxG motif of the vaccinia virus DExH box RNA helicase NPH-II is required for ATP hydrolysis and RNA unwinding but not for RNA binding. J Virol. 1996 Mar;70(3):1706–1713. doi: 10.1128/jvi.70.3.1706-1713.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Gross C. H., Shuman S. Vaccinia virus RNA helicase: nucleic acid specificity in duplex unwinding. J Virol. 1996 Apr;70(4):2615–2619. doi: 10.1128/jvi.70.4.2615-2619.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Götte M., Fackler S., Hermann T., Perola E., Cellai L., Gross H. J., Le Grice S. F., Heumann H. HIV-1 reverse transcriptase-associated RNase H cleaves RNA/RNA in arrested complexes: implications for the mechanism by which RNase H discriminates between RNA/RNA and RNA/DNA. EMBO J. 1995 Feb 15;14(4):833–841. doi: 10.1002/j.1460-2075.1995.tb07061.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Hirling H., Scheffner M., Restle T., Stahl H. RNA helicase activity associated with the human p68 protein. Nature. 1989 Jun 15;339(6225):562–564. doi: 10.1038/339562a0. [DOI] [PubMed] [Google Scholar]
  20. Hodgman T. C. A new superfamily of replicative proteins. Nature. 1988 May 5;333(6168):22–23. doi: 10.1038/333022b0. [DOI] [PubMed] [Google Scholar]
  21. Jiang B., Monroe S. S., Koonin E. V., Stine S. E., Glass R. I. RNA sequence of astrovirus: distinctive genomic organization and a putative retrovirus-like ribosomal frameshifting signal that directs the viral replicase synthesis. Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10539–10543. doi: 10.1073/pnas.90.22.10539. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Jin L., Peterson D. L. Expression, isolation, and characterization of the hepatitis C virus ATPase/RNA helicase. Arch Biochem Biophys. 1995 Oct 20;323(1):47–53. doi: 10.1006/abbi.1995.0008. [DOI] [PubMed] [Google Scholar]
  23. Kadaré G., David C., Haenni A. L. ATPase, GTPase, and RNA binding activities associated with the 206-kilodalton protein of turnip yellow mosaic virus. J Virol. 1996 Nov;70(11):8169–8174. doi: 10.1128/jvi.70.11.8169-8174.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Kim D. W., Gwack Y., Han J. H., Choe J. C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity. Biochem Biophys Res Commun. 1995 Oct 4;215(1):160–166. doi: 10.1006/bbrc.1995.2447. [DOI] [PubMed] [Google Scholar]
  25. Koonin E. V., Choi G. H., Nuss D. L., Shapira R., Carrington J. C. Evidence for common ancestry of a chestnut blight hypovirulence-associated double-stranded RNA and a group of positive-strand RNA plant viruses. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10647–10651. doi: 10.1073/pnas.88.23.10647. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Koonin E. V., Dolja V. V. Evolution and taxonomy of positive-strand RNA viruses: implications of comparative analysis of amino acid sequences. Crit Rev Biochem Mol Biol. 1993;28(5):375–430. doi: 10.3109/10409239309078440. [DOI] [PubMed] [Google Scholar]
  27. Koonin E. V. Similarities in RNA helicases. Nature. 1991 Jul 25;352(6333):290–290. doi: 10.1038/352290c0. [DOI] [PubMed] [Google Scholar]
  28. Laín S., Martín M. T., Riechmann J. L., García J. A. Novel catalytic activity associated with positive-strand RNA virus infection: nucleic acid-stimulated ATPase activity of the plum pox potyvirus helicaselike protein. J Virol. 1991 Jan;65(1):1–6. doi: 10.1128/jvi.65.1.1-6.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Laín S., Riechmann J. L., García J. A. RNA helicase: a novel activity associated with a protein encoded by a positive strand RNA virus. Nucleic Acids Res. 1990 Dec 11;18(23):7003–7006. doi: 10.1093/nar/18.23.7003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Laín S., Riechmann J. L., Martín M. T., García J. A. Homologous potyvirus and flavivirus proteins belonging to a superfamily of helicase-like proteins. Gene. 1989 Oct 30;82(2):357–362. doi: 10.1016/0378-1119(89)90063-2. [DOI] [PubMed] [Google Scholar]
  31. Lee C. G., Hurwitz J. A new RNA helicase isolated from HeLa cells that catalytically translocates in the 3' to 5' direction. J Biol Chem. 1992 Mar 5;267(7):4398–4407. [PubMed] [Google Scholar]
  32. Lohman T. M. Escherichia coli DNA helicases: mechanisms of DNA unwinding. Mol Microbiol. 1992 Jan;6(1):5–14. doi: 10.1111/j.1365-2958.1992.tb00831.x. [DOI] [PubMed] [Google Scholar]
  33. Lohman T. M. Helicase-catalyzed DNA unwinding. J Biol Chem. 1993 Feb 5;268(4):2269–2272. [PubMed] [Google Scholar]
  34. Mastrangelo I. A., Hough P. V., Wall J. S., Dodson M., Dean F. B., Hurwitz J. ATP-dependent assembly of double hexamers of SV40 T antigen at the viral origin of DNA replication. Nature. 1989 Apr 20;338(6217):658–662. doi: 10.1038/338658a0. [DOI] [PubMed] [Google Scholar]
  35. Matson S. W., Kaiser-Rogers K. A. DNA helicases. Annu Rev Biochem. 1990;59:289–329. doi: 10.1146/annurev.bi.59.070190.001445. [DOI] [PubMed] [Google Scholar]
  36. Milburn S. C., Hershey J. W., Davies M. V., Kelleher K., Kaufman R. J. Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif. EMBO J. 1990 Sep;9(9):2783–2790. doi: 10.1002/j.1460-2075.1990.tb07466.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Mirzayan C., Wimmer E. Biochemical studies on poliovirus polypeptide 2C: evidence for ATPase activity. Virology. 1994 Feb 15;199(1):176–187. doi: 10.1006/viro.1994.1110. [DOI] [PubMed] [Google Scholar]
  38. Morozov SYu, Dolja V. V., Atabekov J. G. Probable reassortment of genomic elements among elongated RNA-containing plant viruses. J Mol Evol. 1989 Jul;29(1):52–62. doi: 10.1007/BF02106181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Méthot N., Pause A., Hershey J. W., Sonenberg N. The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence. Mol Cell Biol. 1994 Apr;14(4):2307–2316. doi: 10.1128/mcb.14.4.2307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Nakashima N., Koizumi M., Watanabe H., Noda H. Complete nucleotide sequence of the Nilaparvata lugens reovirus: a putative member of the genus Fijivirus. J Gen Virol. 1996 Jan;77(Pt 1):139–146. doi: 10.1099/0022-1317-77-1-139. [DOI] [PubMed] [Google Scholar]
  41. Pause A., Méthot N., Sonenberg N. The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis. Mol Cell Biol. 1993 Nov;13(11):6789–6798. doi: 10.1128/mcb.13.11.6789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Pause A., Sonenberg N. Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A. EMBO J. 1992 Jul;11(7):2643–2654. doi: 10.1002/j.1460-2075.1992.tb05330.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Peters S. A., Verver J., Nollen E. A., van Lent J. W., Wellink J., van Kammen A. The NTP-binding motif in cowpea mosaic virus B polyprotein is essential for viral replication. J Gen Virol. 1994 Nov;75(Pt 11):3167–3176. doi: 10.1099/0022-1317-75-11-3167. [DOI] [PubMed] [Google Scholar]
  44. Petty I. T., Jackson A. O. Mutational analysis of barley stripe mosaic virus RNA beta. Virology. 1990 Dec;179(2):712–718. doi: 10.1016/0042-6822(90)90138-h. [DOI] [PubMed] [Google Scholar]
  45. Rikkonen M., Peränen J., Käriäinen L. ATPase and GTPase activities associated with Semliki Forest virus nonstructural protein nsP2. J Virol. 1994 Sep;68(9):5804–5810. doi: 10.1128/jvi.68.9.5804-5810.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Rikkonen M., Peränen J., Käriäinen L. Nuclear and nucleolar targeting signals of Semliki Forest virus nonstructural protein nsP2. Virology. 1992 Aug;189(2):462–473. doi: 10.1016/0042-6822(92)90570-f. [DOI] [PubMed] [Google Scholar]
  47. Rodríguez P. L., Carrasco L. Poliovirus protein 2C has ATPase and GTPase activities. J Biol Chem. 1993 Apr 15;268(11):8105–8110. [PubMed] [Google Scholar]
  48. Rouleau M., Smith R. J., Bancroft J. B., Mackie G. A. Purification, properties, and subcellular localization of foxtail mosaic potexvirus 26-kDa protein. Virology. 1994 Oct;204(1):254–265. doi: 10.1006/viro.1994.1530. [DOI] [PubMed] [Google Scholar]
  49. Rozen F., Edery I., Meerovitch K., Dever T. E., Merrick W. C., Sonenberg N. Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F. Mol Cell Biol. 1990 Mar;10(3):1134–1144. doi: 10.1128/mcb.10.3.1134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Scheffner M., Knippers R., Stahl H. RNA unwinding activity of SV40 large T antigen. Cell. 1989 Jun 16;57(6):955–963. doi: 10.1016/0092-8674(89)90334-6. [DOI] [PubMed] [Google Scholar]
  51. Scheffner M., Knippers R., Stahl H. Simian-virus-40 large-T-antigen-catalyzed DNA and RNA unwinding reactions. Eur J Biochem. 1991 Jan 1;195(1):49–54. doi: 10.1111/j.1432-1033.1991.tb15674.x. [DOI] [PubMed] [Google Scholar]
  52. Shapira R., Choi G. H., Nuss D. L. Virus-like genetic organization and expression strategy for a double-stranded RNA genetic element associated with biological control of chestnut blight. EMBO J. 1991 Apr;10(4):731–739. doi: 10.1002/j.1460-2075.1991.tb08004.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Shuman S. Vaccinia virus RNA helicase: an essential enzyme related to the DE-H family of RNA-dependent NTPases. Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10935–10939. doi: 10.1073/pnas.89.22.10935. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Stahl H., Dröge P., Knippers R. DNA helicase activity of SV40 large tumor antigen. EMBO J. 1986 Aug;5(8):1939–1944. doi: 10.1002/j.1460-2075.1986.tb04447.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Subramanya H. S., Bird L. E., Brannigan J. A., Wigley D. B. Crystal structure of a DExx box DNA helicase. Nature. 1996 Nov 28;384(6607):379–383. doi: 10.1038/384379a0. [DOI] [PubMed] [Google Scholar]
  56. Suzich J. A., Tamura J. K., Palmer-Hill F., Warrener P., Grakoui A., Rice C. M., Feinstone S. M., Collett M. S. Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes. J Virol. 1993 Oct;67(10):6152–6158. doi: 10.1128/jvi.67.10.6152-6158.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Tamura J. K., Warrener P., Collett M. S. RNA-stimulated NTPase activity associated with the p80 protein of the pestivirus bovine viral diarrhea virus. Virology. 1993 Mar;193(1):1–10. doi: 10.1006/viro.1993.1097. [DOI] [PubMed] [Google Scholar]
  58. Walker J. E., Saraste M., Runswick M. J., Gay N. J. Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1982;1(8):945–951. doi: 10.1002/j.1460-2075.1982.tb01276.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Warrener P., Collett M. S. Pestivirus NS3 (p80) protein possesses RNA helicase activity. J Virol. 1995 Mar;69(3):1720–1726. doi: 10.1128/jvi.69.3.1720-1726.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Warrener P., Tamura J. K., Collett M. S. RNA-stimulated NTPase activity associated with yellow fever virus NS3 protein expressed in bacteria. J Virol. 1993 Feb;67(2):989–996. doi: 10.1128/jvi.67.2.989-996.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Wengler G., Wengler G. The carboxy-terminal part of the NS 3 protein of the West Nile flavivirus can be isolated as a soluble protein after proteolytic cleavage and represents an RNA-stimulated NTPase. Virology. 1991 Oct;184(2):707–715. doi: 10.1016/0042-6822(91)90440-m. [DOI] [PubMed] [Google Scholar]
  62. Wiekowski M., Schwarz M. W., Stahl H. Simian virus 40 large T antigen DNA helicase. Characterization of the ATPase-dependent DNA unwinding activity and its substrate requirements. J Biol Chem. 1988 Jan 5;263(1):436–442. [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES