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. 1997 Apr;71(4):3168–3177. doi: 10.1128/jvi.71.4.3168-3177.1997

Identification of a novel antiapoptotic protein, GAM-1, encoded by the CELO adenovirus.

S Chiocca 1, A Baker 1, M Cotten 1
PMCID: PMC191449  PMID: 9060680

Abstract

We have developed a simple screening method to identify genes that mimic bcl-2 or adenovirus E1B 19K in enhancing cell survival after transfection and have used this method to identify such a gene in the avian adenovirus CELO. The gene encodes a novel 30-kDa nuclear protein, which we have named GAM-1, that functions comparably to Bcl-2 and adenovirus E1B 19K in blocking apoptosis. However, GAM-1 has no sequence homology to Bcl-2, E1B 19K, or any other known antiapoptotic proteins and thus defines a novel antiapoptotic function.

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Selected References

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