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. 1996 Nov;59(5):1012–1018.

Glutaric aciduria type I in the Arab and Jewish communities in Israel.

Y Anikster 1, A Shaag 1, A Joseph 1, H Mandel 1, B Ben-Zeev 1, E Christensen 1, O N Elpeleg 1
PMCID: PMC1914820  PMID: 8900228

Abstract

Mutation analysis was performed in eight families (16 patients) with glutaric aciduria type I (GA-I), which were all the families diagnosed in Israel in the years 1987-1994. Six families were of Moslem origin and two were non-Ashkenazi Jews. The entire coding region of the cDNA of the glutaryl-CoA dehydrogenase gene was sequenced in one patient of each family. Seven new mutations were identified in 15 of 16 mutated alleles, including six point mutations: T416I (4 alleles), G390R (1 allele), and S305L, A293T, L283P, and G1O1R (2 alleles each). In addition, a 1-bp deletion at position 1173 was identified in two alleles. These findings do not provide a molecular basis for the clinical variability in GA-I families. The occurrence of multiple novel mutations in a small geographic area may be explained by their recent onset in isolated communities with a high consanguinity rate.

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Selected References

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