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. 1997 May;71(5):4098–4102. doi: 10.1128/jvi.71.5.4098-4102.1997

Protein B23 is an important human factor for the nucleolar localization of the human immunodeficiency virus protein Tat.

Y P Li 1
PMCID: PMC191564  PMID: 9094689

Abstract

Nucleolar shuttle protein B23 was found to bind to human immunodeficiency virus protein Tat, and this binding required the nucleolar localization motif of Tat. A fusion protein containing the B23 binding domain and beta-galactosidase caused mislocalization of Tat to the cytoplasm and inhibited the transactivation activity of Tat. These data suggest that B23 is a human factor necessary for the nucleolar localization of Tat.

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Selected References

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