Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1983 Mar;110(3):333–345.

Acute hematogenous staphylococcal osteomyelitis. A description of the natural history in an avian model.

K R Emslie, S Nade
PMCID: PMC1916166  PMID: 6829712

Abstract

A simple and reproducible avian model of acute hematogenous osteomyelitis is described, and the natural history of the disease has been documented. Infection was induced by intravenous injection of bacteria. Chickens were killed 6, 12, 24, 48, 96, and 192 hours following bacterial inoculation, and the left proximal tibia and distal femur were removed for histologic examination. Bacterial deposition initially occurred within the growing ends of metaphyseal tunnels in the hypertrophic region of the zone of cartilage transformation in the growth plate. Bacterial proliferation occluded the vascular tunnel within 24 hours. The initial deposition of bacteria, the subsequent spread, and the nature of the inflammatory process are discussed in relation to the vascular arrangement adjacent to the growth plate. The frequent formation of sequestrum and the effect on the growth plate of an adjacent abscess is described.

Full text

PDF
333

Images in this article

337Figure 2
on p.337
337Figure 3
on p.337
338Figure 4
on p.338
338Figure 5
on p.338
340Figure 7
on p.340
340Figure 8
on p.340
342Figure 10
on p.342
343Figure 11
on p.343
343Figure 12
on p.343

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson C. E., Parker J. Electron microscopy of the epiphyseal cartilage plate. A critical review of electron microscopy observations on enchondral ossification. Clin Orthop Relat Res. 1968 May-Jun;58:225–241. [PubMed] [Google Scholar]
  2. Anderson C. E., Parker J. Invasion and resorption in enchondral ossification. An electron microscopic study. J Bone Joint Surg Am. 1966 Jul;48(5):899–914. [PubMed] [Google Scholar]
  3. Crane L. R., Kapdi C. C., Wolfe J. N., Silberberg B. K., Lerner A. M. Xeroradiographic, bacteriologic, and pathologic studies in experimental staphylococcus osteomyelitis. Proc Soc Exp Biol Med. 1977 Nov;156(2):303–314. doi: 10.3181/00379727-156-39926. [DOI] [PubMed] [Google Scholar]
  4. Deysine M., Rosario E., Isenberg H. D. Acute hematogenous osteomyelitis: an experimental model. Surgery. 1976 Jan;79(1):97–99. [PubMed] [Google Scholar]
  5. Fowles J. V., Lehoux J., Zlitni M., Kassab M. T., Nolan B. Tibial defect due to acute haematogenous osteomyelitis: treatment and results in twenty-one children. J Bone Joint Surg Br. 1979 Feb;61(1):77–81. doi: 10.1302/0301-620X.61B1.422639. [DOI] [PubMed] [Google Scholar]
  6. Hafner D., Heinen E., Noack E. Mathematical analysis of concentration-response relationships. Method for the evaluation of the ED50 and the number of binding sites per receptor molecule using the logit transformation. Arzneimittelforschung. 1977;27(10):1871–1873. [PubMed] [Google Scholar]
  7. Ham K. N., Hurley J. V., Ryan G. B., Storey E. Localization of particulate carbon in metaphyseal vessels of growing rats. Aust J Exp Biol Med Sci. 1965 Oct;43(5):625–638. doi: 10.1038/icb.1965.47. [DOI] [PubMed] [Google Scholar]
  8. Homans J. OSTEOMYELITIS OF THE LONG BONES: A STUDY OF NINETY-FOUR CASES FROM THE CHILDREN'S HOSPITAL, BOSTON. Ann Surg. 1912 Mar;55(3):375–387. doi: 10.1097/00000658-191203000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Howlett C. R. The fine structure of the proximal growth plate and metaphysis of the avian tibia: endochondral osteogenesis. J Anat. 1980 Jun;130(Pt 4):745–768. [PMC free article] [PubMed] [Google Scholar]
  10. Howlett C. R. The fine structure of the proximal growth plate of the avian tibia. J Anat. 1979 Mar;128(Pt 2):377–399. [PMC free article] [PubMed] [Google Scholar]
  11. Kalayjian D. B., Cooper R. R. Osteogenesis of the epiphysis: a light and electron microscopic study. Clin Orthop Relat Res. 1972;85:242–256. doi: 10.1097/00003086-197206000-00037. [DOI] [PubMed] [Google Scholar]
  12. MELLY M. A., THOMISON J. B., ROGERS D. E. Fate of staphylococci within human leukocytes. J Exp Med. 1960 Dec 1;112:1121–1130. doi: 10.1084/jem.112.6.1121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Nairn M. E. Bacterial osteomyelitis and synovitis of the turkey. Avian Dis. 1973 Jul-Sep;17(3):504–517. [PubMed] [Google Scholar]
  14. Norden C. W. Experimental osteomyelitis. I. A description of the model. J Infect Dis. 1970 Nov;122(5):410–418. doi: 10.1093/infdis/122.5.410. [DOI] [PubMed] [Google Scholar]
  15. Ogden J. A. Pediatric osteomyelitis and septic arthritis: the pathology of neonatal disease. Yale J Biol Med. 1979 Sep-Oct;52(5):423–448. [PMC free article] [PubMed] [Google Scholar]
  16. Roberts P. H. Disturbed epiphysial growth at the knee after osteomyelitis in infancy. J Bone Joint Surg Br. 1970 Nov;52(4):692–703. [PubMed] [Google Scholar]
  17. Schenk R. K., Wiener J., Spiro D. Fine structural aspects of vascular invasion of the tibial epiphyseal plate of growing rats. Acta Anat (Basel) 1968;69(1):1–17. doi: 10.1159/000143059. [DOI] [PubMed] [Google Scholar]
  18. Trueta J., Amato V. P. The vascular contribution to osteogenesis. III. Changes in the growth cartilage caused by experimentally induced ischaemia. J Bone Joint Surg Br. 1960 Aug;42-B:571–587. doi: 10.1302/0301-620X.42B3.571. [DOI] [PubMed] [Google Scholar]
  19. Wise D. R., Jennings A. R. The development and morphology of the growth plates of two long bones of the turkey. Res Vet Sci. 1973 Mar;14(2):161–166. [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES