Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1983 Mar;110(3):310–314.

Modification of pancreatic carcinogenesis in the hamster model. 3. Inhibitory effect of alloxan.

P M Pour, K Donnelly, K Stepan
PMCID: PMC1916170  PMID: 6829709

Abstract

Alloxan, when given intravenously at a dose of 60 mg/kg body weight 2 hours prior to subcutaneous injection of the potent pancreatic carcinogen N-nitrosobis (2-oxopropyl) amine (BOP), inhibited the induction of hyperplastic and neoplastic pancreatic lesions in a statistically significant fashion (P less than 0.01). The number of lesions per animal affected was markedly less in these animals, compared with BOP-treated control animals. BOP administration 2 weeks after alloxan treatment, at which time pancreatic islet cell regeneration is considered completed, did not alter either the incidence or number of lesions. The results support our view that the pancreatic islet cells are the primary source of BOP metabolism. The concomitant inhibition of gallbladder tumors, but not of common duct neoplasms, in hamsters receiving BOP 2 hours after alloxan could indicate that alloxan's inhibitory effects on BOP carcinogenesis are not restricted to the pancreas.

Full text

PDF
310

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beitner R., Lahat N. Effect of alloxan diabetes and insulin on lactate dehydrogenase isoenzymes in rat tissues. Nat New Biol. 1973 Feb 28;241(113):281–282. doi: 10.1038/newbio241281a0. [DOI] [PubMed] [Google Scholar]
  2. Bhise K. B., Magar N. G. Enzymatic studies in alloxan-diabetes. Indian J Med Res. 1969 Jul;57(7):1198–1206. [PubMed] [Google Scholar]
  3. Gingell R., Brunk G., Nagel D., Pour P. Metabolism of three radiolabeled pancreatic carcinogenic nitrosamines in hamsters and rats. Cancer Res. 1979 Nov;39(11):4579–4583. [PubMed] [Google Scholar]
  4. Gingell R., Brunk G., Nagel D., Wallcave L., Walker B., Pour P. Metabolism and mutagenicity of N-nitroso-2-methoxy-2,6-dimethylmorpholine in hamsters. J Natl Cancer Inst. 1980 Jan;64(1):157–161. [PubMed] [Google Scholar]
  5. GingellR, Wallcave L., Nagel D., Kupper R., Pour P. Common metabolites of N-nitroso-2,6-dimethylomorpholine and N-nitroso-bis(2-oxopropyl)amine in the Syrian hamster. Cancer Lett. 1976 Sep;2(1):47–52. doi: 10.1016/s0304-3835(76)80010-9. [DOI] [PubMed] [Google Scholar]
  6. HOUSE E. L., NACE P. F., TASSONI J. P. Alloxan diabetes in the hamster: organ changes during the first day. Endocrinology. 1956 Oct;59(4):433–443. doi: 10.1210/endo-59-4-433. [DOI] [PubMed] [Google Scholar]
  7. Kazumi T., Yoshino G., Baba S. Pancreatic islet cell tumors found in rats given alloxan and nicotinamide. Endocrinol Jpn. 1980 Jun;27(3):387–393. doi: 10.1507/endocrj1954.27.387. [DOI] [PubMed] [Google Scholar]
  8. NACE P. F., HOUSE E. L., TASSONI J. P. Alloxan diabetes in the hamster: dosage and blood sugar curves. Endocrinology. 1956 Mar;58(3):305–308. doi: 10.1210/endo-58-3-305. [DOI] [PubMed] [Google Scholar]
  9. Pour P. M., Raha C. R. Pancreatic carcinogenic effect of N-nitrosobis (2-oxobutyl) amine and N-nitroso (2-oxobutyl) (2-oxopropyl) amine in Syrian hamster. Cancer Lett. 1981 Apr;12(3):223–229. doi: 10.1016/0304-3835(81)90072-0. [DOI] [PubMed] [Google Scholar]
  10. Pour P. M., Runge R. G., Birt D., Gingell R., Lawson T., Nagel D., Wallcave L., Salmasi S. Z. Current knowledge of pancreatic carcinogenesis in the hamster and its relevance to the human disease. Cancer. 1981 Mar 15;47(6 Suppl):1573–1589. doi: 10.1002/1097-0142(19810315)47:6+<1573::aid-cncr2820471420>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
  11. Pour P. M., Sayed S., Sayed G. Hyperplastic, preneoplastic and neoplastic lesions found in 83 human pancreases. Am J Clin Pathol. 1982 Feb;77(2):137–152. doi: 10.1093/ajcp/77.2.137. [DOI] [PubMed] [Google Scholar]
  12. Pour P. M., Wallcave L., Nagel D. The effect of N-nitroso-2-methoxy-2,6-dimethylmorpholine on endocrine and exocrine pancreas of Syrian hamsters. Cancer Lett. 1981 Aug;13(3):233–240. doi: 10.1016/0304-3835(81)90023-9. [DOI] [PubMed] [Google Scholar]
  13. Pour P., Althoff J., Krüger F. W., Mohr U. A potent pancreatic carcinogen in Syrian hamsters: N-nitrosobis(2-oxopropyl)amine. J Natl Cancer Inst. 1977 May;58(5):1449–1453. doi: 10.1093/jnci/58.5.1449. [DOI] [PubMed] [Google Scholar]
  14. Pour P., Gingell R., Langenbach R., Nagel D., Grandjean C., Lawson T., Salmasi S. Carcinogenicity of N-nitrosomethyl(2-oxopropyl)amine in Syrian hamsters. Cancer Res. 1980 Oct;40(10):3585–3590. [PubMed] [Google Scholar]
  15. Pour P. Islet cells as a component of pancreatic ductal neoplasms. I. Experimental study: ductular cells, including islet cell precursors, as primary progenitor cells of tumors. Am J Pathol. 1978 Feb;90(2):295–316. [PMC free article] [PubMed] [Google Scholar]
  16. Pour P., Mohr U., Althoff J., Cardesa A., Kmoch N. Spontaneous tumors and common diseases in two colonies of Syrian hamsters. III. Urogenital system and endocrine glands. J Natl Cancer Inst. 1976 May;56(5):949–961. doi: 10.1093/jnci/56.5.949. [DOI] [PubMed] [Google Scholar]
  17. Pour P., Wallcave L., Gingell R., Nagel D., Lawson T., Salmasi S., Tines S. Carcinogenic effect of N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine, a postulated proximate pancreatic carcinogen in Syrian hamsters. Cancer Res. 1979 Oct;39(10):3828–3833. [PubMed] [Google Scholar]
  18. Takahashi M., Pour P. Spontaneous alterations in the pancreas of the aging Syrian golden hamster. J Natl Cancer Inst. 1978 Feb;60(2):355–364. doi: 10.1093/jnci/60.2.355. [DOI] [PubMed] [Google Scholar]
  19. Tiscornia O. M., Janowitz H. D., Dreiling D. A. The effect of alloxan upon canine exocrine pancreatic secretion. Am J Gastroenterol. 1968 Apr;49(4):328–340. [PubMed] [Google Scholar]
  20. Trandaburu T., Ionescu M. Ultrastructural alterations in the pancreatic B-cells of the newt (Triturus vulgaris) induced by alloxan. Acta Anat (Basel) 1971;79(2):257–269. doi: 10.1159/000143642. [DOI] [PubMed] [Google Scholar]
  21. Wilander E., Tjälve H. Diabetogenic effects of N-nitrosomethylurea with special regard to species variations. Exp Pathol (Jena) 1975;11(3-4):133–141. doi: 10.1016/s0014-4908(75)80053-6. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES