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. 1982 Feb;106(2):261–268.

S-100 protein in soft-tissue tumors derived from Schwann cells and melanocytes.

K Stefansson, R Wollmann, M Jerkovic
PMCID: PMC1916175  PMID: 6278936

Abstract

In soft tissues outside the central nervous system, S-100 protein is found normally only in Schwann cells. Using the peroxidase-antiperoxidase immunohistochemical method S-100 was also found in tumors derived from Schwann cells and melanocytes, including neurofibromas, neurilemomas, granular cell myoblastomas, cutaneous nevi, and malignant melanomas. S-100 was not detected in malignant Schwannomas, neuroblastomas, oat cell carcinomas, medullary carcinomas of the thyroid, paragangliomas, or meningiomas. S-100 was also absent from neoplasms of soft tissues not usually considered to arise from cells of neural crest origin. S-100 appears to be a useful marker for identifying neoplasms derived from Schwann cells and melanocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abell M. R., Hart W. R., Olson J. R. Tumors of the peripheral nervous system. Hum Pathol. 1970 Dec;1(4):503–551. [PubMed] [Google Scholar]
  2. BEDNAR B. Storiform neurofibromas of the skin, pigmented and nonpigmented. Cancer. 1957 Mar-Apr;10(2):368–376. doi: 10.1002/1097-0142(195703/04)10:2<368::aid-cncr2820100218>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  3. BERKHEISER S. W., RAPPOPORT A. E. The comparative morphogenesis of the dermo-epidermal nevi and malignant melanoma. Am J Pathol. 1952 May-Jun;28(3):477–495. [PMC free article] [PubMed] [Google Scholar]
  4. Benda P. Protéine S-100 et tumeurs cérébrales humaines. Rev Neurol (Paris) 1968 May;118(5):368–372. [PubMed] [Google Scholar]
  5. Bird C. C., Willis R. A. The histogenesis of pigmented neurofibromas. J Pathol. 1969 Apr;97(4):631–637. doi: 10.1002/path.1710970407. [DOI] [PubMed] [Google Scholar]
  6. Chen K. T., Latorraca R., Fabich D., Padgug A., Hafez G. R., Gilbert E. F. Malignant schwannoma: a light microscopic and ultrastructural study. Cancer. 1980 Apr 1;45(7):1585–1593. doi: 10.1002/1097-0142(19800401)45:7<1585::aid-cncr2820450712>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  7. D'AGOSTINO A. N., SOULE E. H., MILLER R. H. PRIMARY MALIGNANT NEOPLASMS OF NERVES (MALIGNANT NEURILEMOMAS) IN PATIENTS WITHOUT MANIFESTATIONS OF MULTIPLE NEUROFIBROMATOSIS (VON RECKLINGHAUSEN'S DISEASE). Cancer. 1963 Aug;16:1003–1014. doi: 10.1002/1097-0142(196308)16:8<1003::aid-cncr2820160807>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  8. D'AGOSTINO A. N., SOULE E. H., MILLER R. H. SARCOMAS OF THE PERIPHERAL NERVES AND SOMATIC SOFT TISSUES ASSOCIATED WITH MULTIPLE NEUROFIBROMATOSIS (VON RECKLINGHAUSEN'S DISEASE). Cancer. 1963 Aug;16:1015–1027. doi: 10.1002/1097-0142(196308)16:8<1015::aid-cncr2820160808>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  9. Gaynor R., Herschman H. R., Irie R., Jones P., Morton D., Cochran A. S100 protein: a marker for human malignant melanomas? Lancet. 1981 Apr 18;1(8225):869–871. doi: 10.1016/s0140-6736(81)92142-5. [DOI] [PubMed] [Google Scholar]
  10. Ghosh B. C., Ghosh L., Huvos A. G., Fortner J. G. Malignant schwannoma. A clinicopathologic study. Cancer. 1973 Jan;31(1):184–190. doi: 10.1002/1097-0142(197301)31:1<184::aid-cncr2820310126>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  11. Guccion J. G., Enzinger F. M. Malignant Schwannoma associated with von Recklinghausen's neurofibromatosis. Virchows Arch A Pathol Anat Histol. 1979 Jul 27;383(1):43–57. doi: 10.1007/BF00427009. [DOI] [PubMed] [Google Scholar]
  12. Haglid K. G., Stavrou D., Rönnbäck L., Carlsson C. A., Weidenbach W. The S-100 protein in water-soluble and pentanol-extractable form in normal human brain and tumours of the human nervous system. A quantitative study. J Neurol Sci. 1973 Sep;20(1):103–111. doi: 10.1016/0022-510x(73)90122-6. [DOI] [PubMed] [Google Scholar]
  13. Haglid K., Carlsson C. A., Stavrou D. An immunological study of human brain tumors concerning the brain specific protein S-100 and 14.3.2. Acta Neuropathol. 1973 May 16;24(3):187–196. doi: 10.1007/BF00687589. [DOI] [PubMed] [Google Scholar]
  14. Hansson H. A., Persson L., Rönnbäck L., Haglid K. G. Immuno-electron microscopic study of the distribution of the S 100 protein in brain glial cells. Cytobios. 1976;15(57):45–48. [PubMed] [Google Scholar]
  15. Hydén H., McEwen B. A glial protein specific for the nervous system. Proc Natl Acad Sci U S A. 1966 Feb;55(2):354–358. doi: 10.1073/pnas.55.2.354. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Kamata Y. Study on the ultrastructure and acetylcholinesterase activity in von Recklinghausen's neurofibromatosis. Acta Pathol Jpn. 1978 May;28(3):393–410. doi: 10.1111/j.1440-1827.1978.tb01264.x. [DOI] [PubMed] [Google Scholar]
  17. Laidlaw G. F., Murray M. R. Addenda to a Theory of Pigmented Moles. Am J Pathol. 1934 Mar;10(2):319–320. [PMC free article] [PubMed] [Google Scholar]
  18. Lazarus S. S., Trombetta L. D. Ultrastructural identification of a benign perineurial cell tumor. Cancer. 1978 May;41(5):1823–1829. doi: 10.1002/1097-0142(197805)41:5<1823::aid-cncr2820410525>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  19. Levene A. On the histological diagnosis and prognosis of malignant melanoma. J Clin Pathol. 1980 Feb;33(2):101–124. doi: 10.1136/jcp.33.2.101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Ludwin S. K., Kosek J. C., Eng L. F. The topographical distribution of S-100 and GFA proteins in the adult rat brain: an immunohistochemical study using horseradish peroxidase-labelled antibodies. J Comp Neurol. 1976 Jan 15;165(2):197–207. doi: 10.1002/cne.901650206. [DOI] [PubMed] [Google Scholar]
  21. Matus A., Mughal S. Immunohistochemical localisation of S-100 protein in brain. Nature. 1975 Dec 25;258(5537):746–748. doi: 10.1038/258746a0. [DOI] [PubMed] [Google Scholar]
  22. Moore B. W. A soluble protein characteristic of the nervous system. Biochem Biophys Res Commun. 1965 Jun 9;19(6):739–744. doi: 10.1016/0006-291x(65)90320-7. [DOI] [PubMed] [Google Scholar]
  23. Perez V. J., Olney J. W., Cicero T. J., Moore B. W., Bahn B. A. Wallerian degeneration in rabbit optic nerve: cellular localization in the central nervous system of the S-100 and 14-3-2 proteins. J Neurochem. 1970 Apr;17(4):511–519. doi: 10.1111/j.1471-4159.1970.tb00529.x. [DOI] [PubMed] [Google Scholar]
  24. Pfeiffer S. E., Wechsler W. Biochemically differentiated neoplastic clone of Schwann cells. Proc Natl Acad Sci U S A. 1972 Oct;69(10):2885–2889. doi: 10.1073/pnas.69.10.2885. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Poirier J., Escourolle R., Castaigne P. Les neurobibromes de la maladie de Recklinghausen. Etude ultrastructurale et place nosologique par rapport aux neurinomes. Acta Neuropathol. 1968 Jun 7;10(4):279–294. doi: 10.1007/BF00690704. [DOI] [PubMed] [Google Scholar]
  26. Rawles M. E. The Development of Melanophores from Embryonic Mouse Tissues Grown in the Coelom of Chick Embryos. Proc Natl Acad Sci U S A. 1940 Dec 15;26(12):673–680. doi: 10.1073/pnas.26.12.673. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Reed R. J., Leonard D. D. Neurotropic melanoma. A variant of desmoplastic melanoma. Am J Surg Pathol. 1979 Aug;3(4):301–311. doi: 10.1097/00000478-197908000-00002. [DOI] [PubMed] [Google Scholar]
  28. Sviridov S. M., Korochkin L. I., Ivanov V. N., Maletskaya E. I., Bakhtina T. K. Immunohistochemical studies of S-100 protein during postnatal ontogenesis of the brain of two strains of rats. J Neurochem. 1972 Mar;19(3):713–718. doi: 10.1111/j.1471-4159.1972.tb01386.x. [DOI] [PubMed] [Google Scholar]
  29. Tsuneyoshi M., Enjoji M. Primary malignant peripheral nerve tumors (malignant schwannomas). A clinicopathologic and electron microscopic study. Acta Pathol Jpn. 1979 May;29(3):363–375. doi: 10.1111/j.1440-1827.1979.tb00194.x. [DOI] [PubMed] [Google Scholar]
  30. Waggener J. D. Ultrastructure of benign peripheral nerve sheath tumors. Cancer. 1966 May;19(5):699–709. doi: 10.1002/1097-0142(196605)19:5<699::aid-cncr2820190516>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  31. Wahlström T., Saxén L. Malignant skin tumors of neural crest origin. Cancer. 1976 Nov;38(5):2022–2026. doi: 10.1002/1097-0142(197611)38:5<2022::aid-cncr2820380526>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  32. Wechsler W., Pfeiffer S. E., Swenberg J. A., Koestner A. S-100 protein in methyl- and ethylnitrosourea induced tumors of the rat nervous system. Acta Neuropathol. 1973;24(4):287–303. doi: 10.1007/BF00685585. [DOI] [PubMed] [Google Scholar]

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