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. 1982 Feb;106(2):165–170.

Epithelioid granuloma formation requiring no T-cell function.

A Tanaka, K Emori, S Nagao, K Kushima, O Kohashi, M Saitoh, T Kataoka
PMCID: PMC1916186  PMID: 6978073

Abstract

Muramyl dipeptide (MDP), a minimal structure in bacterial cell walls essential for their adjuvant activity, was incorporated in a water-in-oil emulsion and injected into the footpads of nude rats devoid of functional T cells. MDP thus injected evoked massive epithelioid granulomas in the draining lymph nodes, indicating that MDP induced epithelioid granuloma formation requires no T cells. This finding with other data available strongly suggest that epithelioid granulomas can be induced without immunologic reactions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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