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. 1982 Jun;107(3):357–361.

Use of monoclonal antibodies in detection of melanoma-associated antigens in intact human tumors.

J J Thompson, M F Herlyn, D E Elder, W H Clark, Z Steplewski, H Koprowski
PMCID: PMC1916245  PMID: 6177248

Abstract

The use of antimelanoma monoclonal antibodies on tissue sections using a two-step indirect immunoperoxidase technique is reported. Antibodies 691-13-17 and 691-I5-Nu4B reacted with dysplastic nevus cells and all melanomas tested, but not with normal skin melanocytes, intradermal nevi, or lentigines. Antibody 691-13-17, directed against DR antigen, reacted also with Langerhan's cells, macrophages, and a subpopulation of lymphocytes. Antibody 691-I5-Nu4B reacted only with melanomas. The technique allows analysis of the expression of antigens by tumor cells in situ.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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