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. 1992 Jul;36(7):1577–1579. doi: 10.1128/aac.36.7.1577

Stability of meropenem and effect of 1 beta-methyl substitution on its stability in the presence of renal dehydropeptidase I.

M Fukasawa 1, Y Sumita 1, E T Harabe 1, T Tanio 1, H Nouda 1, T Kohzuki 1, T Okuda 1, H Matsumura 1, M Sunagawa 1
PMCID: PMC191626  PMID: 1510457

Abstract

The stability of meropenem in the presence of renal dehydropeptidase I (DHP-I) varied extremely with the animal source of the enzyme. Meropenem, compared with imipenem, was rather easily hydrolyzed by DHP-Is from mice, rabbits, and monkeys, while it showed a higher resistance to guinea pig and beagle dog DHP-Is. In addition, meropenem was four times more resistant than imipenem to human DHP-I. The 1 beta-methyl substituent on carbapenems, i.e., meropenem and 1 beta-methyl imipenem, made them considerably more resistant to mouse and swine DHP-Is than the 1-unsubstituted derivatives are.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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