Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1983 May;111(2):224–233.

Clinical and pathologic features of cyclic hematopoiesis in grey collie dogs.

R F DiGiacomo, W P Hammond, L L Kunz, P A Cox
PMCID: PMC1916339  PMID: 6846503

Abstract

Clinical and pathologic features of cyclic hematopoiesis in 18 grey collie dogs, aged 10 to 113 weeks, were reviewed. The dogs were grouped according to weeks of age: 10-16 (I), 17-21 (II), 30-35 (III), and less than 52 (IV). Clinical illness occurring during each hematopoietic cycle was classified as none, mild, moderate, or severe, based on the neutrophil count, rectal temperature, clinical signs, and use of antimicrobial therapy. The dogs in Groups I, III, and IV had severe infections episodes during one-fourth of all hematopoietic cycles; whereas the dogs in Group II had severe infections during two-thirds of cycles. However, during the cycle prior to death, all groups were similar, each having two-thirds of clinical syndromes classified as severe and one-third as mild. More dogs died during the neutropenic phase of the hematopoietic cycle than during the nonneutropenic phase. Pathologic findings showed distinct patterns in relation to age. Younger dogs showed evidence of acute infectious processes, especially in the lungs, gastrointestinal tract, and kidneys; whereas older dogs had chronic inflammatory changes in those organs. Amyloidosis was a prominent finding in dogs over 30 weeks of age. These findings indicate that predictable age-related changes in tissues of grey collie dogs impair various organ systems and thereby contribute to morbidity and mortality in older dogs. consequently, future clinical and pathologic studies of grey collies should take into consideration the age of the dogs under study.

Full text

PDF
224

Images in this article

229Figure 2
on p.229
229Figure 3
on p.229
230Figure 4
on p.230
230Figure 5
on p.230
231Figure 6
on p.231
231Figure 7
on p.231

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adamson J. W., Dale D. C., Elin R. J. Hematopoiesis in the grey collie dog: studies of the regulation of erythropoiesis. J Clin Invest. 1974 Oct;54(4):965–973. doi: 10.1172/JCI107837. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cheville N. F. Amyloidosis associated with cyclic neutropenia in the dog. Blood. 1968 Jan;31(1):111–114. [PubMed] [Google Scholar]
  3. Cheville N. F., Cutlip R. C., Moon H. W. Microscopic pathology of the gray collie syndrome. Cyclic neutropenia, amyloidosis, enteritis, and bone necrosis. Pathol Vet. 1970;7(3):225–245. doi: 10.1177/030098587000700302. [DOI] [PubMed] [Google Scholar]
  4. Cheville N. F. The gray Collie syndrome. J Am Vet Med Assoc. 1968 Mar 15;152(6):620–630. [PubMed] [Google Scholar]
  5. Dale D. C., Alling D. W., Wolff S. M. Cyclic hematopoiesis: the mechanism of cyclic neutropenia in grey collie dogs. J Clin Invest. 1972 Aug;51(8):2197–2204. doi: 10.1172/JCI107027. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dale D. C., Ward S. B., Kimball H. R., Wolff S. M. Studies of neutrophil production and turnover in grey collie dogs with cyclic neutropenia. J Clin Invest. 1972 Aug;51(8):2190–2196. doi: 10.1172/JCI107026. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ford L. Hereditary aspects of human and canine cyclic neutropenia. J Hered. 1969 Sep-Oct;60(5):293–299. doi: 10.1093/oxfordjournals.jhered.a107998. [DOI] [PubMed] [Google Scholar]
  8. Gregory R. S., Machado E. A., Jones J. B. Animal model of human disease. Amyloidosis. Am J Pathol. 1977 Jun;87(3):721–724. [PMC free article] [PubMed] [Google Scholar]
  9. Hammond W. P., Engelking E. R., Dale D. C. Cyclic hematopoiesis. Effects of endotoxin on colony-forming cells and colony-stimulating activity in grey collie dogs. J Clin Invest. 1979 Apr;63(4):785–792. doi: 10.1172/JCI109363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hammond W. P., Price T. H., Dale D. C. Canine cyclic hematopoiesis: effects of chronic endotoxin administration. Blood. 1978 Dec;52(6):1170–1177. [PubMed] [Google Scholar]
  11. Jones J. B., Lange R. D., Jones E. S. Cyclic hematopoiesis in a colony of dogs. J Am Vet Med Assoc. 1975 Feb 15;166(4):365–367. [PubMed] [Google Scholar]
  12. Lund J. E., Padgett G. A., Gorham J. R. Additional evidence on the inheritance of cyclic neutropenia in the dog. J Hered. 1970 Mar-Apr;61(2):47–49. doi: 10.1093/oxfordjournals.jhered.a108033. [DOI] [PubMed] [Google Scholar]
  13. Lund J. E., Padgett G. A., Ott R. L. Cyclic neutropenia in grey collie dogs. Blood. 1967 Apr;29(4):452–461. [PubMed] [Google Scholar]
  14. Machado E. A., Gregory R. S., Jones J. B., Lange R. D. The cyclic hematopoietic dog: a model for spontaneous secondary amyloidosis. A morphologic study. Am J Pathol. 1978 Jul;92(1):23–34. [PMC free article] [PubMed] [Google Scholar]
  15. Patt H. M., Lund J. E., Maloney M. A. Cyclic hematopoiesis in grey collie dogs: a stem-cell problem. Blood. 1973 Dec;42(6):873–884. [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES