Skip to main content
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1966 Feb;48(2):197–239.

A correlative histochemical, biochemical and electron microscopic study of experimental atherosclerosis in the rabbit aorta with special reference to the myo-intimal cell.

F Parker, G F Odland
PMCID: PMC1916426  PMID: 5904499

Full text

PDF
197

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADAMS C. W., BAYLISS O. B., IBRAHIM M. Z. A hypothesis to explain the accumulation of cholesterol in atherosclerosis. Lancet. 1962 Apr 28;1(7235):890–892. doi: 10.1016/s0140-6736(62)91914-1. [DOI] [PubMed] [Google Scholar]
  2. BALIS J. U., HAUST M. D., MORE R. H. ELECTRON-MICROSCOPIC STUDIES IN HUMAN ATHEROSCLEROSIS; CELLULAR ELEMENTS IN AORTIC FATTY STREAKS. Exp Mol Pathol. 1964 Oct;90:511–525. doi: 10.1016/0014-4800(64)90031-0. [DOI] [PubMed] [Google Scholar]
  3. BARRON E. J., HANAHAN D. J. Observations on the silicic acid chromatography of the neutral lipides of rat liver, beef liver, and yeast. J Biol Chem. 1958 Mar;231(1):493–503. [PubMed] [Google Scholar]
  4. BARTLETT G. R. Phosphorus assay in column chromatography. J Biol Chem. 1959 Mar;234(3):466–468. [PubMed] [Google Scholar]
  5. BENNETT H. S., LUFT J. H., HAMPTON J. C. Morphological classifications of vertebrate blood capillaries. Am J Physiol. 1959 Feb;196(2):381–390. doi: 10.1152/ajplegacy.1959.196.2.381. [DOI] [PubMed] [Google Scholar]
  6. BIERRING F., KOBAYASI T. Electron microscopy of the normal rabbit aorta. Acta Pathol Microbiol Scand. 1963;57:154–168. doi: 10.1111/j.1699-0463.1963.tb03440.x. [DOI] [PubMed] [Google Scholar]
  7. BIGGS M. W., KRITCHEVSKY D. Observations with radioactive hydrogen (H3) in experimental atherosclerosis. Circulation. 1951 Jul;4(1):34–42. doi: 10.1161/01.cir.4.1.34. [DOI] [PubMed] [Google Scholar]
  8. BILLIAU A., EVRARD E., VAN DEN BOSCH J., JOOSSENS J. V., DE SOMER P. The fatty acid distribution in plasma, liver and aorta of cholesterol-fed and Triton-treated rabbits. J Atheroscler Res. 1963 May-Jun;3:222–232. doi: 10.1016/s0368-1319(63)80073-3. [DOI] [PubMed] [Google Scholar]
  9. BUCK R. C. Lesions in the rabbit aorta produced by feeding a high cholesterol diet followed by a normal diet. An electron microscopic study. Br J Exp Pathol. 1962 Jun;43:236–240. [PMC free article] [PubMed] [Google Scholar]
  10. BUCK R. C. The fine structure of the aortic endothelial lesions in experimental cholesterol atherosclerosis of rabbits. Am J Pathol. 1958 Sep-Oct;34(5):897–909. [PMC free article] [PubMed] [Google Scholar]
  11. CASPER J., WOLMAN M. DEMONSTRATION OF MYELIN FIGURES BY FLUORESCENCE IN SOME PATHOLOGIC TISSUES. Lab Invest. 1964 Jan;13:27–31. [PubMed] [Google Scholar]
  12. CHAPMAN J. A. Fibroblasts and collagen. Br Med Bull. 1962 Sep;18:233–237. doi: 10.1093/oxfordjournals.bmb.a069985. [DOI] [PubMed] [Google Scholar]
  13. CONKLIN J. L. Staining reactions of mucopolysaccharides after formalin-containing fixatives. Stain Technol. 1963 Jan;38:56–59. [PubMed] [Google Scholar]
  14. COURCHAINE A. J., MILLER W. H., STEIN D. B., Jr Rapid semi-micro procedure for estimating free and total cholesterol. Clin Chem. 1959 Dec;5:609–614. [PubMed] [Google Scholar]
  15. COURTICE F. C., SCHMIDT-DIEDRICHS A. Lipid deposition in the injured wall of the carotid artery in the hypercholesterolaemic and hyperlipaemic rabbit. Q J Exp Physiol Cogn Med Sci. 1962 Jul;47:228–237. doi: 10.1113/expphysiol.1962.sp001601. [DOI] [PubMed] [Google Scholar]
  16. CRAWFORD T. Morphological aspects in the pathogenesis of atherosclerosis. J Atheroscler Res. 1961 Jan-Feb;1:3–25. doi: 10.1016/s0368-1319(61)80050-1. [DOI] [PubMed] [Google Scholar]
  17. CUTHBERTSON W. F., ELCOATE P. V., IRELAND D. M., MILLS D. C., SHEARLEY P. Serum-cholesterol levels and atherosclerosis: effects of composition of diet and tri-iodothyronine on the rat. Br J Nutr. 1959;13(2):227–242. doi: 10.1079/bjn19590030. [DOI] [PubMed] [Google Scholar]
  18. DAY A. J. The relationship of arterial macrophages to the phospholipid content in rabbit atheroma. J Atheroscler Res. 1962 Sep-Oct;2:350–364. doi: 10.1016/s0368-1319(62)80039-8. [DOI] [PubMed] [Google Scholar]
  19. DOLE V. P. A relation between non-esterified fatty acids in plasma and the metabolism of glucose. J Clin Invest. 1956 Feb;35(2):150–154. doi: 10.1172/JCI103259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. DUFF G. L., McMILLAN G. C. Pathology of atherosclerosis. Am J Med. 1951 Jul;11(1):92–108. doi: 10.1016/0002-9343(51)90011-3. [DOI] [PubMed] [Google Scholar]
  21. DUFF G. L., McMILLAN G. C., RITCHIE A. C. The morphology of early atherosclerotic lesions of the aorta demonstrated by the surface technique in rabbits fed cholesterol; together with a description of the anatomy of the intima of the rabbit's aorta and the spontaneous lesions which occur in it. Am J Pathol. 1957 Sep-Oct;33(5):845–873. [PMC free article] [PubMed] [Google Scholar]
  22. FLOREY H. W., GREER S. J., KISER J., POOLE J. C., TELANDER R., WERTHESSEN N. T. The development of the pseudointima lining fabric grafts of the aorta. Br J Exp Pathol. 1962 Dec;43:655–660. [PMC free article] [PubMed] [Google Scholar]
  23. FLOREY H. W., GREER S. J., POOLE J. C., WERTHESSEN N. T. The pseudointima lining fabric grafts of the aorta. Br J Exp Pathol. 1961 Jun;42:236–246. [PMC free article] [PubMed] [Google Scholar]
  24. FOLCH J., LEES M., SLOANE STANLEY G. H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957 May;226(1):497–509. [PubMed] [Google Scholar]
  25. GEER J. C., GUIDRY M. A. CHOLESTERYL ESTER COMPOSITION AND MORPHOLOGY OF HUMAN NORMAL INTIMA AND FATTY STREAKS. Exp Mol Pathol. 1964 Oct;90:485–499. doi: 10.1016/0014-4800(64)90029-2. [DOI] [PubMed] [Google Scholar]
  26. GEER J. C., McGILL H. C., Jr, STRONG J. P. The fine structure of human atherosclerotic lesions. Am J Pathol. 1961 Mar;38:263–287. [PMC free article] [PubMed] [Google Scholar]
  27. GUTSTEIN W. H., LAZZARINI-ROBERTSON A., Jr, LATAILLADE J. N. The role of local arterial irritability in the development of arterio-atherosclerosis. Am J Pathol. 1963 Jan;42:61–71. [PMC free article] [PubMed] [Google Scholar]
  28. HAUST M. D., MORE R. H., MOVAT H. Z. The role of smooth muscle cells in the fibrogenesis of arteriosclerosis. Am J Pathol. 1960 Oct;37:377–389. [PMC free article] [PubMed] [Google Scholar]
  29. HAUST M. D., WYLLIE J. C., MORE R. H. ELECTRON MICROSCOPY OF FIBRIN IN HUMAN ATHEROSCLEROTIC LESIONS; IMMUNOHISTOCHEMICAL AND MORPHOLOGIC IDENTIFICATION. Exp Mol Pathol. 1965 Apr;28:205–216. doi: 10.1016/0014-4800(65)90033-x. [DOI] [PubMed] [Google Scholar]
  30. HESS R., STAEUBLI W. THE DEVELOPMENT OF AORTIC LIPIDOSIS IN THE RAT. A CORRELATIVE HISTOCHEMICAL AND ELECTRON MICROSCOPIC STUDY. Am J Pathol. 1963 Sep;43:301–335. [PMC free article] [PubMed] [Google Scholar]
  31. KARRER H. E. An electron microscope study of the aorta in young and in aging mice. J Ultrastruct Res. 1961 Mar;5:1–27. doi: 10.1016/s0022-5320(61)80002-6. [DOI] [PubMed] [Google Scholar]
  32. KEECH M. K. Electron microscope study of the normal rat aorta. J Biophys Biochem Cytol. 1960 Jun;7:533–538. doi: 10.1083/jcb.7.3.533. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. KORN E. D. Clearing factor, a heparin-activated lipoprotein lipase. I. Isolation and characterization of the enzyme from normal rat heart. J Biol Chem. 1955 Jul;215(1):1–14. [PubMed] [Google Scholar]
  34. MCGEE W. G., ASHWORTH C. T. FINE STRUCTURE OF CHRONIC HYPERTENSIVE ARTERIOPATHY IN THE HUMAN KIDNEY. Am J Pathol. 1963 Aug;43:273–299. [PMC free article] [PubMed] [Google Scholar]
  35. MILLONIG G. A modified procedure for lead staining of thin sections. J Biophys Biochem Cytol. 1961 Dec;11:736–739. doi: 10.1083/jcb.11.3.736. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. MOORE J. H., WILLIAMS D. L. THE RELATIONSHIP BETWEEN DIET, PLASMA LIPID COMPOSITION AND AORTIC ATHEROSIS IN RABBITS. Br J Nutr. 1964;18:431–448. doi: 10.1079/bjn19640039. [DOI] [PubMed] [Google Scholar]
  37. NEWMAN H. A., ZILVERSMIT D. B. ACCUMULATION OF LIPID AND NONLIPID CONSTITUENTS IN RABBIT ATHEROMA. J Atheroscler Res. 1964 May-Jun;4:261–271. doi: 10.1016/s0368-1319(64)80008-9. [DOI] [PubMed] [Google Scholar]
  38. ODLAND G. F. The fine structure of the interrelationship of cells in the human epidermis. J Biophys Biochem Cytol. 1958 Sep 25;4(5):529–538. [PMC free article] [PubMed] [Google Scholar]
  39. PARKER F., SCHIMMELBUSCH W., WILLIAMS R. H. THE ENZYMATIC NATURE OF PHOSPHOLIPID SYNTHESIS IN NORMAL RABBIT AND HUMAN AORTA. RESULTS OF IN VITRO STUDIES. Diabetes. 1964 Mar-Apr;13:182–188. doi: 10.2337/diab.13.2.182. [DOI] [PubMed] [Google Scholar]
  40. PEASE D. C., PAULE W. J. Electron microscopy of elastic arteries; the thoracic aorta of the rat. J Ultrastruct Res. 1960 Jun;3:469–483. doi: 10.1016/s0022-5320(60)90023-x. [DOI] [PubMed] [Google Scholar]
  41. Parker F. An Electron Microscopic Study of Experimental Atherosclerosis. Am J Pathol. 1960 Jan;36(1):19–53. [PMC free article] [PubMed] [Google Scholar]
  42. RHODIN J. A. Fine structure of vascular walls in mammals with special reference to smooth muscle component. Physiol Rev Suppl. 1962 Jul;5:48–87. [PubMed] [Google Scholar]
  43. ROSS R., BENDITT E. P. Wound healing and collagen formation. III. A quantitative radioautographic study of the utilization of proline-H3 in wounds from normal and scorbutic guinea pigs. J Cell Biol. 1962 Oct;15:99–108. doi: 10.1083/jcb.15.1.99. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. SAKO Y., NAKMURA M. Electron microscopic studies on the rabbit aorta in acute hypercholesterolemia. Jpn Heart J. 1963 Jan;4:53–68. doi: 10.1536/ihj.4.53. [DOI] [PubMed] [Google Scholar]
  45. SCHWENK E., STEVENS D. F. Deposition of cholesterol in experimental rabbit atherosclerosis. Proc Soc Exp Biol Med. 1960 Mar;103:614–617. doi: 10.3181/00379727-103-25613. [DOI] [PubMed] [Google Scholar]
  46. SCOTT R. F., MORRISON E. S., THOMAS W. A., JONES R., NAM S. C. SHORT-TERM FEEDING OF UNSATURATED VERSUS SATURATED FAT IN THE PRODUCTION OF ATHEROSCLEROSIS IN THE RAT. Exp Mol Pathol. 1964 Oct;90:421–443. doi: 10.1016/0014-4800(64)90024-3. [DOI] [PubMed] [Google Scholar]
  47. SHORE M. L., ZILVERSMIT D. B., ACKERMAN R. F. Plasma phospholipide deposition and aortic phospholipide synthesis in experimental atherosclerosis. Am J Physiol. 1955 Jun;181(3):527–531. doi: 10.1152/ajplegacy.1955.181.3.527. [DOI] [PubMed] [Google Scholar]
  48. SPRARAGEN S. C., BOND V. P., DAHL L. K. Role of hyperplasia in vascular lesions of cholesterol-fed rabbits studied with thymidine-H3 autoradiography. Circ Res. 1962 Aug;11:329–336. doi: 10.1161/01.res.11.2.329. [DOI] [PubMed] [Google Scholar]
  49. STEIN Y., STEIN O., SHAPIRO B. Enzymic pathways of glyceride and phospholipid synthesis in aortic homogenates. Biochim Biophys Acta. 1963 Feb 19;70:33–42. doi: 10.1016/0006-3002(63)90716-9. [DOI] [PubMed] [Google Scholar]
  50. STILL W. J. AN ELECTRON MICROSCOPE STUDY OF CHOLESTEROL ATHEROSCLEROSIS IN THE RABBIT. Exp Mol Pathol. 1963 Dec;14:491–502. doi: 10.1016/0014-4800(63)90026-1. [DOI] [PubMed] [Google Scholar]
  51. STILL W. J., MARRIOTT P. R. COMPARATIVE MORPHOLOGY OF THE EARLY ATHEROSCLEROTIC LESION IN MAN AND CHOLESTEROL-ATHEROSCLEROSIS IN THE RABBIT AN ELECTRONMICROSCOPIC STUDY. J Atheroscler Res. 1964 Sep-Oct;4:373–386. doi: 10.1016/s0368-1319(64)80023-5. [DOI] [PubMed] [Google Scholar]
  52. STILL W. J., PROSSER P. R. THE REACTION OF AORTIC ENDOTHELIUM OF THE RABBIT TO HYPERLIPEMIA AND COLLOIDAL THORIUM. J Atheroscler Res. 1964 Nov-Dec;4:517–526. doi: 10.1016/s0368-1319(64)80054-5. [DOI] [PubMed] [Google Scholar]
  53. WANG C. I., SCHAEFER L. E., DRACHMAN S. R., ADLERSBERG D. Plasma lipid partition of the normal and cholesterol-fed rabbit. J Mt Sinai Hosp N Y. 1954 May-Jun;21(1):19–25. [PubMed] [Google Scholar]
  54. ZUGIBE F. T. HISTOCHEMICAL STUDIES OF HUMAN CORONARY ATHEROGENESIS: COMPARISON WITH AORTIC AND CEREBRAL ATHEROGENESIS. Circ Res. 1963 Nov;13:401–409. doi: 10.1161/01.res.13.5.401. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES