Skip to main content
PMC home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1966 Mar;48(3):347–373.

Early effects of pyrrolizidine alkaloids on the fine structure of rat liver cells.

D Svoboda, J Soga
PMCID: PMC1916433  PMID: 5907764

Full text

PDF
347

Images in this article

361Figs. 1-2
on p.361
363Figs. 3-4
on p.363
365Figs. 5-8
on p.365
366Figs. 9-10
on p.366
367Fig. 11
on p.367
369Fig. 12
on p.369
371Figs. 13-15
on p.371
373Figs. 16-17
on p.373

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARKER E. A., SMUCKLER E. A., BENDITT E. P. EFFECTS OF THIOACETAMIDE AND YELLOW PHOSPHORUS POISONING ON PROTEIN SYNTHESIS IN VIVO. Lab Invest. 1963 Oct;12:955–960. [PubMed] [Google Scholar]
  2. BRADFIELD J. R., GIBBONS I. R. The fixation of cell nuclei by osmium tetroxide. Biochim Biophys Acta. 1956 Dec;22(3):506–513. doi: 10.1016/0006-3002(56)90061-0. [DOI] [PubMed] [Google Scholar]
  3. BRAS G., BROOKS S. E., WATLER D. C. Cirrhosis of the liver in Jamaica. J Pathol Bacteriol. 1961 Oct;82:503–512. doi: 10.1002/path.1700820226. [DOI] [PubMed] [Google Scholar]
  4. BRAS G., JELLIFFE D. B., STUART K. L. Veno-occlusive disease of liver with nonportal type of cirrhosis, occurring in Jamaica. AMA Arch Pathol. 1954 Apr;57(4):285–300. [PubMed] [Google Scholar]
  5. BRAS G., MCLEAN E. TOXIC FACTORS IN VENO-OCCLUSIVE DISEASE. Ann N Y Acad Sci. 1963 Dec 30;111:392–398. doi: 10.1111/j.1749-6632.1963.tb36979.x. [DOI] [PubMed] [Google Scholar]
  6. BULL L. B., DICK A. T., McKENZIE J. S. The acute toxic effects of heliotrine and lasiocarpine, and their N-oxides, on the rat. J Pathol Bacteriol. 1958 Jan;75(1):17–25. doi: 10.1002/path.1700750104. [DOI] [PubMed] [Google Scholar]
  7. BULL L. B., DICK A. T. The chronic pathological effects on the liver of the rat of the pyrrolizidine alkaloids heliotrine, lasiocarpine, and their N-oxides. J Pathol Bacteriol. 1959 Oct;78:483–502. doi: 10.1002/path.1700780215. [DOI] [PubMed] [Google Scholar]
  8. BUSCH H., BYVOET P., SMETANA K. The nucleolus of the cancer cell: a review. Cancer Res. 1963 Mar;23:313–339. [PubMed] [Google Scholar]
  9. CHIPCHASE M. I., BIRNSTIEL M. L. ON THE NATURE OF NUCLEOLAR RNA. Proc Natl Acad Sci U S A. 1963 Dec;50:1101–1107. doi: 10.1073/pnas.50.6.1101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. COOK J. W., DUFFY E., SCHOENTAL R. Primary liver tumours in rats following feeding with alkaloids of Senecio jacobaea. Br J Cancer. 1950 Dec;4(4):405–410. doi: 10.1038/bjc.1950.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. FUKUOKA F., ONO T., OHASHI M., NISHIMURA S. Effect of 4-nitroquinoline N-oxide on the metabolism of cancer cells in vitro. Gan. 1959 Mar;50(1):23–35. [PubMed] [Google Scholar]
  12. GALLAGHER C. H. The effect of pyrrolizidine alkaloids on liver enzyme systems. Biochem Pharmacol. 1960 Jun;3:220–230. doi: 10.1016/0006-2952(60)90110-6. [DOI] [PubMed] [Google Scholar]
  13. GIRARD M., PENMAN S., DARNELL J. E. THE EFFECT OF ACTINOMYCIN ON RIBOSOME FORMATION IN HELA CELLS. Proc Natl Acad Sci U S A. 1964 Feb;51:205–211. doi: 10.1073/pnas.51.2.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. HOLTZER R. L., ODA A., CHIGA M. EFFECT OF ACTINOMYCIN D ON DEOXYCYTIDYLATE DEAMINASE ACTIVITY OF RAT LIVER AFTER PARTIAL HEPATECTOMY. Lab Invest. 1964 Dec;13:1514–1519. [PubMed] [Google Scholar]
  15. HRUBAN Z., SPARGO B., SWIFT H., WISSLER R. W., KLEINFELD R. G. Focal cytoplasmic degradation. Am J Pathol. 1963 Jun;42:657–683. [PMC free article] [PubMed] [Google Scholar]
  16. JOURNEY L. J., GOLDSTEIN M. N. Electron microscope studies on HeLa cell lines sensitive and resistant to actinomycin D. Cancer Res. 1961 Aug;21:929–932. [PubMed] [Google Scholar]
  17. MARINOZZI V. CYTOCHIMIE ULTRASTRUCTURALE DU NUCL'EOLE--RNA ET PROT'EINES INTRANUCL'EOLAIRES. J Ultrastruct Res. 1964 Jun;10:433–456. doi: 10.1016/s0022-5320(64)80021-6. [DOI] [PubMed] [Google Scholar]
  18. MCLEAN E., BRAS G., GYOERGY P. VENO-OCCLUSIVE LESIONS IN LIVERS OF RATS FED CROTALARIA FULVA. Br J Exp Pathol. 1964 Jun;45:242–247. [PMC free article] [PubMed] [Google Scholar]
  19. McELROY O. E., ANDERSON P. R., GRAY I. Effect of tourniquet injury on the tryrosine oxidizing system of liver of rats. Arch Biochem Biophys. 1958 May;75(1):69–77. doi: 10.1016/0003-9861(58)90398-9. [DOI] [PubMed] [Google Scholar]
  20. ODA A., CHIGA M. EFFECT OF ACTINOMYCIN D ON THE HEPATIC CELLS OF PARTIALLY HEPATECTOMIZED RATS. AN ELECTRON MICROSCOPIC STUDY. Lab Invest. 1965 Jul;14:1419–1427. [PubMed] [Google Scholar]
  21. PETERSON J. E. EFFECTS OF THE PYRROLIZIDINE ALKALOID, LASIOCARPINE N-OXIDE, ON NUCLEAR AND CELL DIVISION IN THE LIVER RATS. J Pathol Bacteriol. 1965 Jan;89:153–171. doi: 10.1002/path.1700890117. [DOI] [PubMed] [Google Scholar]
  22. REYNOLDS R. C., MONTGOMERY P. O., HUGHES B. NUCLEOLAR "CAPS" PRODUCED BY ACTINOMYCIN D. Cancer Res. 1964 Aug;24:1269–1277. [PubMed] [Google Scholar]
  23. REYNOLDS R. C., MONTGOMERY P. O., KARNEY D. H. Nucleolars "caps'--a morphologic entity produced by the carcinogen 4-nitroquinoline N-oxide. Cancer Res. 1963 May;23:535–538. [PubMed] [Google Scholar]
  24. RHO J. H., BONNER J. The site of ribonucleic acid synthesis in the isolated nucleus. Proc Natl Acad Sci U S A. 1961 Oct 15;47:1611–1619. doi: 10.1073/pnas.47.10.1611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. SCHEUER P. J. Histochemical changes in rat liver in Senecio and thioacetamide poisoning. J Pathol Bacteriol. 1963 Apr;85:507–516. doi: 10.1002/path.1700850231. [DOI] [PubMed] [Google Scholar]
  26. SCHOEFL G. I. THE EFFECT OF ACTINOMYCIN D ON THE FINE STRUCTURE OF THE NUCLEOLUS. J Ultrastruct Res. 1964 Apr;10:224–243. doi: 10.1016/s0022-5320(64)80007-1. [DOI] [PubMed] [Google Scholar]
  27. SCHOENTAL R., HEAD M. A. Pathological changes in rats as a result of treatment with monocrotaline. Br J Cancer. 1955 Mar;9(1):229–237. doi: 10.1038/bjc.1955.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. SCHOENTAL R., HEAD M. A. Progression of liver lesions produced in rats by temporary treatment with pyrrolizidine (senecio) alkaloids, and the effects of betaine and high casein diet. Br J Cancer. 1957 Dec;11(4):535–544. doi: 10.1038/bjc.1957.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. SCHOENTAL R., MAGEE P. N. Further observations on the subacute and chronic liver changes in rats after a single dose of various pyrrolizidine (Senecio) alkaloids. J Pathol Bacteriol. 1959 Oct;78:471–482. doi: 10.1002/path.1700780213. [DOI] [PubMed] [Google Scholar]
  30. SELZER G., PARKER R. G. F., SAPEIKA N. An experimental study of senecio poisoning in rats. Br J Exp Pathol. 1951 Feb;32(1):14–20. [PMC free article] [PubMed] [Google Scholar]
  31. SELZER G., PARKER R. G. F. Senecio poisoning exhibiting as Chiari's syndrome; a report on twelve cases. Am J Pathol. 1951 Sep-Oct;27(5):885–907. [PMC free article] [PubMed] [Google Scholar]
  32. SMUCKLER E. A., ISERI O. A., BENDITT E. P. An intracellular defect in protein synthesis induced by carbon tetrachloride. J Exp Med. 1962 Jul 1;116:55–72. doi: 10.1084/jem.116.1.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. STEVENS B. J. THE EFFECT OF ACTINOMYCIN D ON NUCLEOLAR AND NUCLEAR FINE STRUCTURE IN THE SALIVARY GLAND CELL OF HIRONOMUS THUMMI. J Ultrastruct Res. 1964 Oct;11:329–353. doi: 10.1016/s0022-5320(64)90037-1. [DOI] [PubMed] [Google Scholar]
  34. STONER H. B., MAGEE P. N. Experimental studies on toxic liver injury. Br Med Bull. 1957 May;13(2):102–107. doi: 10.1093/oxfordjournals.bmb.a069584. [DOI] [PubMed] [Google Scholar]
  35. TULPULE P. G., MADHAVAN T. V., GOPALAN C. EFFECT OF FEEDING AFLATOXIN TO YOUNG MONKEYS. Lancet. 1964 May 2;1(7340):962–963. doi: 10.1016/s0140-6736(64)91748-9. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES