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. 1966 Apr;48(4):535–555.

The ultrastructure of fatty liver induced by prolonged ethanol ingestion.

O A Iseri, C S Lieber, L S Gottlieb
PMCID: PMC1916443  PMID: 5936783

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Selected References

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  1. AMICK C. J., STENGER R. J. ULTRASTRUCTURAL ALTERATIONS IN EXPERIMENTAL ACUTE HEPATIC FATTY METAMORPHOSIS. Lab Invest. 1964 Feb;13:128–136. [PubMed] [Google Scholar]
  2. Ashworth C. T., Johnson C. F., Wrightsman F. J. Biochemical and Morphologic Correlations of Hepatic Protein Synthesis in Acute Ethanol Intoxication in Rats. Am J Pathol. 1965 May;46(5):757–773. [PMC free article] [PubMed] [Google Scholar]
  3. BARKER E. A., SMUCKLER E. A., BENDITT E. P. EFFECTS OF THIOACETAMIDE AND YELLOW PHOSPHORUS POISONING ON PROTEIN SYNTHESIS IN VIVO. Lab Invest. 1963 Oct;12:955–960. [PubMed] [Google Scholar]
  4. BENNETT H. S., LUFT J. H. zeta-Collidine as a basis for buffering fixatives. J Biophys Biochem Cytol. 1959 Aug;6(1):113–114. doi: 10.1083/jcb.6.1.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BIAVA C. MALLORY ALCOHOLIC HYALIN: A HERETOFORE UNIQUE LESION OF HEPATOCELLULAR ERGASTOPLASM. Lab Invest. 1964 Apr;13:301–320. [PubMed] [Google Scholar]
  6. Bruni C., Porter K. R. The Fine Structure of the Parenchymal Cell of the Normal Rat Liver: I. General Observations. Am J Pathol. 1965 May;46(5):691–755. [PMC free article] [PubMed] [Google Scholar]
  7. FARBER E., LOMBARDI B., CASTILLO A. E. THE PREVENTION BY ADENOSINE TRIPHOSPHATE OF THE FATTY LIVER INDUCED BY ETHIONINE. Lab Invest. 1963 Sep;12:873–883. [PubMed] [Google Scholar]
  8. FLAX M. H., TISDALE W. A. AN ELECTRON MICROSCOPIC STUDY OF ALCOHOLIC HYALIN. Am J Pathol. 1964 Mar;44:441–453. [PMC free article] [PubMed] [Google Scholar]
  9. FRENCH S. W. SUCCINIC DEHYDROGENASE: HISTOCHEMICAL "SHIFT" IN HEPATIC LOBULAR DISTRIBUTION INDUCED BY ETHANOL. Lab Invest. 1964 Sep;13:1051–1056. [PubMed] [Google Scholar]
  10. HORNING M. G., WILLIAMS E. A., MALING H. M., BRODIE B. B. Depot fat as source of increased liver triglycerides after ethanol. Biochem Biophys Res Commun. 1960 Dec;3:635–640. doi: 10.1016/0006-291x(60)90077-2. [DOI] [PubMed] [Google Scholar]
  11. JATLOW P., ADAMS W. R., HANDSCHUMACHER R. E. PATHOGENESIS OF OROTIC ACID-INDUCED FATTY CHANGE IN THE RAT LIVER: LIGHT AND ELECTRON MICROSCOPIC STUDIES. Am J Pathol. 1965 Jul;47:125–145. [PMC free article] [PubMed] [Google Scholar]
  12. KARNOVSKY M. J. Simple methods for "staining with lead" at high pH in electron microscopy. J Biophys Biochem Cytol. 1961 Dec;11:729–732. doi: 10.1083/jcb.11.3.729. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. KIESSLING K. H., TILANDER K. The effect of prolonged alcohol treatment on the respiration of liver and brain mitochondria from male and female rats. Exp Cell Res. 1963 May;30:476–480. doi: 10.1016/0014-4827(63)90324-0. [DOI] [PubMed] [Google Scholar]
  14. LIEBER C. S., DAVIDSON C. S. Some metabolic effects of ethyl alcohol. Am J Med. 1962 Sep;33:319–327. doi: 10.1016/0002-9343(62)90229-2. [DOI] [PubMed] [Google Scholar]
  15. LIEBER C. S., JONES D. P., DECARLI L. M. EFFECTS OF PROLONGED ETHANOL INTAKE: PRODUCTION OF FATTY LIVER DESPITE ADEQUATE DIETS. J Clin Invest. 1965 Jun;44:1009–1021. doi: 10.1172/JCI105200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. LIEBER C. S. PATHOGENESIS OF HEPATIC STEATOSIS. Gastroenterology. 1963 Dec;45:760–764. [PubMed] [Google Scholar]
  17. LIEBER C. S., SCHMID R. The effect of ethanol on fatty acid metabolism; stimulation of hepatic fatty acid synthesis in vitro. J Clin Invest. 1961 Feb;40:394–399. doi: 10.1172/JCI104266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. LUFT J. H. Improvements in epoxy resin embedding methods. J Biophys Biochem Cytol. 1961 Feb;9:409–414. doi: 10.1083/jcb.9.2.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. MALLOV S., BLOCH J. L. Role of hypophysis and adrenals in fatty infiltration of liver resulting from acute ethanol intoxication. Am J Physiol. 1956 Jan;184(1):29–34. doi: 10.1152/ajplegacy.1955.184.1.29. [DOI] [PubMed] [Google Scholar]
  20. PFEIFFER C. [Electron-optical research on the rat liver following chronic ethyl and methyl alcohol administration]. Experientia. 1961 Sep 15;17:431–432. doi: 10.1007/BF02157994. [DOI] [PubMed] [Google Scholar]
  21. Porta E. A., Hartroft W. S., De la Iglesia F. A. Hepatic changes associated with chronic alcoholism in rats. Lab Invest. 1965 Aug;14(8):1437–1455. [PubMed] [Google Scholar]
  22. REBOUCAS G., ISSELBACHER K. J. Studies on the pathogenesis of the ethanol-induced fatty liver. I. Synthesis and oxidation of fatty acids by the liver. J Clin Invest. 1961 Aug;40:1355–1362. doi: 10.1172/JCI104366. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. REYNOLDS E. S. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol. 1963 Apr;17:208–212. doi: 10.1083/jcb.17.1.208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. RICHARDSON K. C., JARETT L., FINKE E. H. Embedding in epoxy resins for ultrathin sectioning in electron microscopy. Stain Technol. 1960 Nov;35:313–323. doi: 10.3109/10520296009114754. [DOI] [PubMed] [Google Scholar]
  25. ROBINSON D. S., SEAKINS A. The development in the rat of fatty livers associated with reduced plasma-lipoprotein synthesis. Biochim Biophys Acta. 1962 Jul 30;62:163–165. doi: 10.1016/0006-3002(62)90502-4. [DOI] [PubMed] [Google Scholar]
  26. SCHEIG R., ISSELBACHER K. J. PATHOGENESIS OF ETHANOL-INDUCED FATTY LIVER. 3. IN VIVO AND VITRO EFFECTS OF ETHANOL ON HEPATIC FATTY ACID METABOLISM IN RATS. J Lipid Res. 1965 Apr;6:269–277. [PubMed] [Google Scholar]
  27. SMUCKLER E. A., BENDITT E. P. Carbon tetrachloride poisoning in rats: alteration in ribosomes of the liver. Science. 1963 Apr 19;140(3564):308–310. doi: 10.1126/science.140.3564.308. [DOI] [PubMed] [Google Scholar]
  28. SMUCKLER E. A., ISERI O. A., BENDITT E. P. An intracellular defect in protein synthesis induced by carbon tetrachloride. J Exp Med. 1962 Jul 1;116:55–72. doi: 10.1084/jem.116.1.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. SVOBODA D., HIGGINSON J. ULTRASTRUCTURAL CHANGES PRODUCED BY PROTEIN AND RELATED DEFICIENCIES IN THE RAT LIVER. Am J Pathol. 1964 Sep;45:353–379. [PMC free article] [PubMed] [Google Scholar]
  30. Seakins A., Robinson D. S. Changes associated with the production of fatty livers by white phosphorus and by ethanol in the rat. Biochem J. 1964 Aug;92(2):308–312. doi: 10.1042/bj0920308. [DOI] [PMC free article] [PubMed] [Google Scholar]

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