Skip to main content
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1966 Jul;49(1):129–151.

Delayed hepatitis and cirrhosis in weanling rats following a single small dose of the senecio alkaloid, lasiocarpine.

J P Nolan, R L Scheig, G Klatskin
PMCID: PMC1916461  PMID: 5944756

Full text

PDF
129

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARTHOLOMEW L. G., CAIN J. C., BAGGENSTOSS A. H., HAGEDORN A. B. Further obervations on hepatitis and cirrhosis in young women with positive clot tests for lupus erythematousus. Gastroenterology. 1960 Dec;39:730–736. [PubMed] [Google Scholar]
  2. BRUCE H. M., PARKES A. S. Feeding and breeding of laboratory animals; a complete cubed diet for mice and rats. J Hyg (Lond) 1949 Jun;47(2):202–208. doi: 10.1017/s0022172400014479. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BULL L. B., DICK A. T. The chronic pathological effects on the liver of the rat of the pyrrolizidine alkaloids heliotrine, lasiocarpine, and their N-oxides. J Pathol Bacteriol. 1959 Oct;78:483–502. doi: 10.1002/path.1700780215. [DOI] [PubMed] [Google Scholar]
  4. GRISHAM J. W., HARTROFT W. S. Morphologic identification by electron microscopy of "oval" cells in experimental hepatic degeneration. Lab Invest. 1961 Mar-Apr;10:317–332. [PubMed] [Google Scholar]
  5. HILL K. R. Hepatic veno-occlusive disease produced experimentally in rats by the injection of monocrotaline. Lancet. 1958 Mar 22;1(7021):623–623. doi: 10.1016/s0140-6736(58)90874-2. [DOI] [PubMed] [Google Scholar]
  6. HOENIG V., HOENIGOVA J. COMPLEMENT FIXATION AFTER CARBON-TETRACHLORIDE INJECTION IN RATS. Lancet. 1963 Oct 19;2(7312):842–843. doi: 10.1016/s0140-6736(63)90544-0. [DOI] [PubMed] [Google Scholar]
  7. JONES W. A., CASTLEMAN B. Liver disease in young women with hyperglobulinemia. Am J Pathol. 1962 Mar;40:315–329. [PMC free article] [PubMed] [Google Scholar]
  8. POST J., HUANG C. Y., HOFFMAN J. The replication time and pattern of the liver cell in the growing rat. J Cell Biol. 1963 Jul;18:1–12. doi: 10.1083/jcb.18.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. SCHEUER P. J. Histochemical changes in rat liver in Senecio and thioacetamide poisoning. J Pathol Bacteriol. 1963 Apr;85:507–516. doi: 10.1002/path.1700850231. [DOI] [PubMed] [Google Scholar]
  10. SCHOENTAL R., BENSTED J. P. EFFECTS OF WHOLE BODY IRRADIATION AND OF PARTIAL HEPATECTOMY ON THE LIVER LESIONS INDUCED IN RATS BY A SINGLE DOSE OF RETRORSINE, A PYRROLIZIDINE (SENECIO) ALKALOID. Br J Cancer. 1963 Jun;17:242–251. doi: 10.1038/bjc.1963.34. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. SCHOENTAL R., MAGEE P. N. Further observations on the subacute and chronic liver changes in rats after a single dose of various pyrrolizidine (Senecio) alkaloids. J Pathol Bacteriol. 1959 Oct;78:471–482. doi: 10.1002/path.1700780213. [DOI] [PubMed] [Google Scholar]
  12. SELZER G., PARKER R. G. F., SAPEIKA N. An experimental study of senecio poisoning in rats. Br J Exp Pathol. 1951 Feb;32(1):14–20. [PMC free article] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES