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. 1985 Jul;85(3):705–712. doi: 10.1111/j.1476-5381.1985.tb10567.x

The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response.

H Ali, S B Christensen, J C Foreman, F L Pearce, W Piotrowski, O Thastrup
PMCID: PMC1916512  PMID: 2411328

Abstract

The ability of thapsigargin and thapsigargicin to activate mast cells and leukocytes has been investigated. The thapsigargin-induced histamine release from rat peritoneal mast cells was found to be dependent on the concentration of thapsigargin, the purity of the mast cell preparations, and the number of mast cells in suspension. Thapsigargin induced histamine release from human basophil leukocytes. Thapsigargin induced beta-glucuronidase and lysozyme release from human neutrophil leukocytes. Thapsigargin caused a release of histamine from mesentery, lung, and heart mast cells of the rat, but only to a minor extent from the corresponding guinea-pig cells. Thapsigargicin induced histamine release from mesentery, lung, and heart mast cells of the rat at concentrations from 0.1 microM but provoked only a release from the corresponding guinea-pig cells in the concentration-range 0.16 to 1.6 microM. Thapsigargin increased the cytoplasmic free calcium level in intact human blood platelets at concentrations from 3.0 nM.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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