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. 1985 Jul;85(3):635–638. doi: 10.1111/j.1476-5381.1985.tb10558.x

Effects of chronic administration of amitriptyline or mianserin on rat cardiac and central adrenoceptors.

L Choudhury, J M O'Donnell
PMCID: PMC1916516  PMID: 2992668

Abstract

Rats were administered either amitriptyline (20 mg kg-1, i.p.) or mianserin (10 mg kg-1, i.p.) for 21 consecutive days and the alpha- and beta-adrenoceptor characteristics of cardiac ventricles, cerebral cortex and hippocampus examined by ligand-binding procedure. Chronic administration of amitriptyline significantly reduced the maximum density of beta-receptors in the cerebral cortex without significantly altering cardiac alpha- or beta-receptors; mianserin treatment had no significant effect on any of the receptors studied.

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Selected References

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