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. 1986 Jan;87(1):243–247. doi: 10.1111/j.1476-5381.1986.tb10177.x

Effect of vasoactive peptides on prostacyclin synthesis in man.

S E Barrow, C T Dollery, D J Heavey, N E Hickling, J M Ritter, J Vial
PMCID: PMC1916907  PMID: 3513880

Abstract

Bradykinin, angiotensin II, arginine vasopressin (AVP) or des-amino-D-arginine vasopressin (DDAVP) were administered by intravenous infusion to 10 healthy men. The concentration of 6-oxo-prostaglandin F1 alpha (6-oxo-PGF1 alpha), the stable hydrolysis product of prostacyclin (PGI2), was measured in plasma using gas chromatography/negative ion chemical ionisation mass spectrometry. Dose-related increases in plasma concentrations of 6-oxo-PGF1 alpha occurred during administration of bradykinin (100-3200 ng kg-1 min-1). The concentrations of 6-oxo-PGF1 alpha rose from baseline values in the range less than 1.0-4.9 pg ml-1 to 24.9-47.6 pg ml-1 at maximum tolerated infusion rates. There were no changes in the concentrations of 6-oxo-PGF1 alpha during administration of angiotensin II, AVP or DDAVP at infusion rates which caused haemodynamic changes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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