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. 1986 Oct;89(2):307–312. doi: 10.1111/j.1476-5381.1986.tb10261.x

Probenecid potentiates the hyperglycaemic effect but reduces the diuretic effect of frusemide in mice.

P E Sandström
PMCID: PMC1917023  PMID: 3779212

Abstract

The effect of probenecid on frusemide-induced diuresis and hyperglycaemia was studied in mice. Probenecid, a known inhibitor of tubular secretion of organic anions in the kidney, strongly reduced the diuretic response to frusemide (25 or 200 mg kg-1 body weight). This effect of probenecid appeared to be dose-dependent up to 240 mg kg-1 body weight, at least at the lower concentration of frusemide. Pretreatment with probenecid (240 mg kg-1 body weight) potentiated the hyperglycaemic effect of frusemide (25 or 200 mg kg-1 body weight). The results show that probenecid has opposite effects on frusemide-induced diuresis and hyperglycaemia in mice. It is suggested that the acute hyperglycaemic effect of frusemide is not directly linked to diuresis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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