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. 1997 Jun;71(6):4842–4846. doi: 10.1128/jvi.71.6.4842-4846.1997

Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest.

L Selig 1, S Benichou 1, M E Rogel 1, L I Wu 1, M A Vodicka 1, J Sire 1, R Benarous 1, M Emerman 1
PMCID: PMC191711  PMID: 9151883

Abstract

The Vpr protein encoded by human immunodeficiency virus type 1 (HIV-1) is important for growth of virus in macrophages and prevents infected cells from passing into mitosis (G2 arrest). The cellular target for these functions is not known, but Vpr of HIV-1 and the related Vpr from simian immunodeficiency virus of sooty mangabeys (SIV(SM)) bind the DNA repair enzyme UNG, while the Vpx protein of SIV(SM) does not. Nonetheless, a mutational analysis of Vpr showed that binding to UNG is neither necessary nor sufficient for the effect of Vpr on the cell cycle.

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Selected References

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