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. 1986 Nov;89(3):461–467. doi: 10.1111/j.1476-5381.1986.tb11145.x

Systemic baclofen stimulates gastric motility and secretion via a central action in the rat.

P L Andrews, K L Wood
PMCID: PMC1917152  PMID: 3801782

Abstract

Intravenous (0.5 mg kg-1) or subcutaneous (2-16 mg kg-1) administration of the gamma-aminobutyric acid (GABA) analogue baclofen resulted in a stimulation of gastric motility and secretion in the rat, anaesthetized with urethane. The motility response to subcutaneous injection was dose-related. This effect was abolished by vagotomy or atropine. There was no response to baclofen in decerebrate animals. These results indicate that systemic baclofen, probably acting at a site rostral to the brainstem, stimulates gastric motility and acid secretion by a vagally-dependent mechanism.

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Selected References

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  1. Andrews P. L. The non-adrenergic non-cholinergic innervation of the stomach. Arch Int Pharmacodyn Ther. 1986 Apr;280(2 Suppl):84–109. [PubMed] [Google Scholar]
  2. Bowery N. G., Hill D. R., Hudson A. L., Doble A., Middlemiss D. N., Shaw J., Turnbull M. (-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor. Nature. 1980 Jan 3;283(5742):92–94. doi: 10.1038/283092a0. [DOI] [PubMed] [Google Scholar]
  3. Bowery N. G., Hill D. R., Hudson A. L. [3H](-)Baclofen: an improved ligand for GABAB sites. Neuropharmacology. 1985 Mar;24(3):207–210. doi: 10.1016/0028-3908(85)90075-9. [DOI] [PubMed] [Google Scholar]
  4. Bugajski J., Hano J., Danek L., Wantuch C. The action of serotonin on basal gastric secretion in the conscious rat after intraventricular and intraperitoneal administration. Arch Int Pharmacodyn Ther. 1977 Jan;225(1):29–38. [PubMed] [Google Scholar]
  5. Costall B., Gunning S. J., Naylor R. J. An analysis of the hypothalamic sites at which substituted benzamide drugs act to facilitate gastric emptying in the guinea-pig. Neuropharmacology. 1985 Sep;24(9):869–875. doi: 10.1016/0028-3908(85)90038-3. [DOI] [PubMed] [Google Scholar]
  6. ELIASSON S. Cerebral influence on gastric motility in the cat. Acta Physiol Scand Suppl. 1952;26(95):1–70. [PubMed] [Google Scholar]
  7. GHOSH M. N., SCHILD H. O. Continuous recording of acid gastric secretion in the rat. Br J Pharmacol Chemother. 1958 Mar;13(1):54–61. doi: 10.1111/j.1476-5381.1958.tb00190.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Goto Y., Debas H. T. GABA-mimetic effect on gastric acid secretion. Possible significance in central mechanisms. Dig Dis Sci. 1983 Jan;28(1):56–59. doi: 10.1007/BF01393361. [DOI] [PubMed] [Google Scholar]
  9. Goto Y., Hollinshead J. W., Debas H. T. A new intraoperative test for completeness of vagotomy: the PCP-GABA (beta-parachlorophenol-gamma-aminobutyric acid) test. Am J Surg. 1984 Jan;147(1):159–163. doi: 10.1016/0002-9610(84)90051-5. [DOI] [PubMed] [Google Scholar]
  10. Goto Y., Tache Y., Debas H., Novin D. Gastric acid and vagus nerve response to GABA agonist baclofen. Life Sci. 1985 Jul 1;36(26):2471–2475. doi: 10.1016/0024-3205(85)90143-2. [DOI] [PubMed] [Google Scholar]
  11. Grijalva C. V., Lindholm E., Novin D. Physiological and morphological changes in the gastrointestinal tract induced by hypothalamic intervention: an overview. Brain Res Bull. 1980;5 (Suppl 1):19–31. doi: 10.1016/0361-9230(80)90299-3. [DOI] [PubMed] [Google Scholar]
  12. Grundy D., Scratcherd T. Effect of stimulation of the vagus nerve in bursts on gastric acid secretion and motility in the anaesthetized ferret. J Physiol. 1982 Dec;333:451–461. doi: 10.1113/jphysiol.1982.sp014463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ishikawa T., Osumi Y., Nakagawa T. Cholecystokinin intracerebroventricularly applied stimulates gastric acid secretion. Brain Res. 1985 Apr 29;333(1):197–199. doi: 10.1016/0006-8993(85)90147-7. [DOI] [PubMed] [Google Scholar]
  14. Kerwin R., Pycock C. Baclofen (beta-p-chlorophenyl-gamma-aminobutyric acid) enhances [3H]gamma-aminobutyric acid (3H-GABA) release from rat globus pallidus in vitro. J Pharm Pharmacol. 1978 Oct;30(10):622–627. doi: 10.1111/j.2042-7158.1978.tb13343.x. [DOI] [PubMed] [Google Scholar]
  15. LYTHGOE J. P. Comparison of the insulin and electrical stimulation tests for completeness of vagotomy. Br Med J. 1961 Apr 29;1(5234):1196–1200. doi: 10.1136/bmj.1.5234.1196. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Morley J. E., Levine A. S., Silvis S. E. Intraventricular calcitonin inhibits gastric acid secretion. Science. 1981 Nov 6;214(4521):671–673. doi: 10.1126/science.7292006. [DOI] [PubMed] [Google Scholar]
  17. Morley J. E., Steinbach J. H., Feldman E. J., Solomon T. E. The effects of thyrotropin releasing hormone (TRH) on the gastrointestinal tract. Life Sci. 1979 Mar 19;24(12):1059–1065. doi: 10.1016/0024-3205(79)90038-9. [DOI] [PubMed] [Google Scholar]
  18. Olpe H. R., Demiéville H., Baltzer V., Bencze W. L., Koella W. P., Wolf P., Haas H. L. The biological activity of d- and l-baclofen (Lioresal). Eur J Pharmacol. 1978 Nov 1;52(1):133–136. doi: 10.1016/0014-2999(78)90032-8. [DOI] [PubMed] [Google Scholar]
  19. Potashner S. J. Baclofen: effects on amino acid release. Can J Physiol Pharmacol. 1978 Feb;56(1):150–154. doi: 10.1139/y78-019. [DOI] [PubMed] [Google Scholar]
  20. Waldmeier P. C., Maitre L. Effects of baclofen on dopamine metabolism and interaction with neuroleptic effects. Eur J Pharmacol. 1978 Jan 15;47(2):191–200. doi: 10.1016/0014-2999(78)90390-4. [DOI] [PubMed] [Google Scholar]

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