Abstract
The preliminary characterization of `vasocortin' a novel glucocorticoid-induced anti-inflammatory protein, is described. Vasocortin is released into the rat peritoneal cavity following systemic dexamethasone administration, has an apparent mol. wt. of 100 kD and inhibits rat dextran oedema. Vasocortin is distinct from lipocortin and is likely to be associated with the anti-inflammatory effect of glucocorticoids.
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Selected References
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- Blackwell G. J., Carnuccio R., Di Rosa M., Flower R. J., Langham C. S., Parente L., Persico P., Russel-Smith N. C., Stone D. Glucocorticoids induce the formation and release of anti-inflammatory and anti-phospholipase proteins into the peritoneal cavity of the rat. Br J Pharmacol. 1982 May;76(1):185–194. doi: 10.1111/j.1476-5381.1982.tb09205.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Blackwell G. J., Carnuccio R., Di Rosa M., Flower R. J., Parente L., Persico P. Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids. Nature. 1980 Sep 11;287(5778):147–149. doi: 10.1038/287147a0. [DOI] [PubMed] [Google Scholar]
- Calignano A., Carnuccio R., Di Rosa M., Ialenti A., Moncada S. The anti-inflammatory effect of glucocorticoid-induced phospholipase inhibitory proteins. Agents Actions. 1985 Mar;16(1-2):60–62. doi: 10.1007/BF01999650. [DOI] [PubMed] [Google Scholar]
- Carnuccio R., Di Rosa M., Persico P. Hydrocortisone-induced inhibitor of prostaglandin biosynthesis in rat leucocytes. Br J Pharmacol. 1980 Jan;68(1):14–16. doi: 10.1111/j.1476-5381.1980.tb10691.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cloix J. F., Colard O., Rothhut B., Russo-Marie F. Characterization and partial purification of 'renocortins': two polypeptides formed in renal cells causing the anti-phospholipase-like action of glucocorticoids. Br J Pharmacol. 1983 May;79(1):313–321. doi: 10.1111/j.1476-5381.1983.tb10526.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Di Rosa M., Calignano A., Carnuccio R., Ialenti A., Sautebin L. Multiple control of inflammation by glucocorticoids. Agents Actions. 1986 Jan;17(3-4):284–289. doi: 10.1007/BF01982621. [DOI] [PubMed] [Google Scholar]
- Di Rosa M., Flower R. J., Hirata F., Parente L., Russo-Marie F. Anti-phospholipase proteins. Prostaglandins. 1984 Oct;28(4):441–442. doi: 10.1016/0090-6980(84)90232-6. [DOI] [PubMed] [Google Scholar]
- Di Rosa M., Willoughby D. A. Screens for anti-inflammatory drugs. J Pharm Pharmacol. 1971 Apr;23(4):297–298. doi: 10.1111/j.2042-7158.1971.tb08661.x. [DOI] [PubMed] [Google Scholar]
- Hirata F., Notsu Y., Iwata M., Parente L., DiRosa M., Flower R. J. Identification of several species of phospholipase inhibitory protein(s) by radioimmunoassay for lipomodulin. Biochem Biophys Res Commun. 1982 Nov 16;109(1):223–230. doi: 10.1016/0006-291x(82)91588-1. [DOI] [PubMed] [Google Scholar]
- Hirata F., Schiffmann E., Venkatasubramanian K., Salomon D., Axelrod J. A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids. Proc Natl Acad Sci U S A. 1980 May;77(5):2533–2536. doi: 10.1073/pnas.77.5.2533. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Oyanagui Y., Suzuki S. Vasoregulin, a glucocorticoid-inducible vascular permeability inhibitory protein. Agents Actions. 1986 Jan;17(3-4):270–277. doi: 10.1007/BF01982619. [DOI] [PubMed] [Google Scholar]